1,1,1-Trifluoroethyl-PEG4-amine

1,1,1-Trifluoroethyl-PEG4-amine Property

Boiling point:

315.1±37.0 °C(Predicted)

Density 

1.151±0.06 g/cm3(Predicted)

pka

8.74±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

1,1,1-Trifluoroethyl-PEG4-amine Chemical Properties,Usage,Production

Description

1, 1, 1-Trifluoroethyl-PEG4-Amine is a PEG linker with a trifluoroethyl and amine moiety. The amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.

Uses

111-Trifluoroethyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005