1,1,1-Trifluoroethyl-PEG2-azide
- Product Name
- 1,1,1-Trifluoroethyl-PEG2-azide
- CAS No.
- 1835759-68-6
- Chemical Name
- 1,1,1-Trifluoroethyl-PEG2-azide
- Synonyms
- 1,1,1-Trifluoroethyl-PEG2-azide
- CBNumber
- CB33162799
- Molecular Formula
- C6H10F3N3O2
- Formula Weight
- 213.16
- MOL File
- 1835759-68-6.mol
1,1,1-Trifluoroethyl-PEG2-azide Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- BP-22926
- Product name
- 1,1,1-Trifluoroethyl-PEG2-azide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- BP-22926
- Product name
- 1,1,1-Trifluoroethyl-PEG2-azide
- Purity
- 98%
- Packaging
- 1g
- Price
- $1100
- Updated
- 2021/12/16
1,1,1-Trifluoroethyl-PEG2-azide Chemical Properties,Usage,Production
Description
1,1,1-Trifluoroethyl-PEG2-azide is a crosslinker containing an azide group and a trifluroethyl group. The azide group can participate in Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The hydrophilic PEG spacer increases solubility in aqueous media. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces.
Uses
1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
1,1,1-Trifluoroethyl-PEG2-azide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,1,1-Trifluoroethyl-PEG2-azide manufacturers
- Product
- 1,1,1-Trifluoroethyl-PEG2-azide 1835759-68-6
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-27