1,1,1-Trifluoroethyl-PEG5-Alcohol
- Product Name
- 1,1,1-Trifluoroethyl-PEG5-Alcohol
- CAS No.
- 1807512-41-9
- Chemical Name
- 1,1,1-Trifluoroethyl-PEG5-Alcohol
- Synonyms
- 1,1,1-Trifluoroethyl-PEG4-alcohol;1,1,1-Trifluoroethyl-PEG5-Alcohol;14,14,14-trifluoro-3,6,9,12-tetraoxatetradecan-1-ol;3,6,9,12-Tetraoxatetradecan-1-ol, 14,14,14-trifluoro-
- CBNumber
- CB53062264
- Molecular Formula
- C10H19F3O5
- Formula Weight
- 276.25
- MOL File
- 1807512-41-9.mol
1,1,1-Trifluoroethyl-PEG5-Alcohol Property
- Boiling point:
- 324.8±37.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- pka
- 14.36±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-22793
- Product name
- 1,1,1-Trifluoroethyl-PEG5-alcohol
- Purity
- 98%
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- BP-22793
- Product name
- 1,1,1-Trifluoroethyl-PEG5-alcohol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
1,1,1-Trifluoroethyl-PEG5-Alcohol Chemical Properties,Usage,Production
Description
1,1,1-Trifluoroethyl-PEG5-alcohol is a PEG linker containing a trifluoroethyl and alcohol group. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces. The alcohol group can react to further derivatize the compound. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
Uses
1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
1,1,1-Trifluoroethyl-PEG5-Alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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