ChemicalBook > CAS DataBase List > PEG6-(CH2CO2H)2

PEG6-(CH2CO2H)2

Product Name
PEG6-(CH2CO2H)2
CAS No.
77855-76-6
Chemical Name
PEG6-(CH2CO2H)2
Synonyms
CAS_77855-76-6;PEG6-(CH2CO2H)2;HOOCCH2O-PEG5-CH2COOH;COOH-CH2-PEG5-CH2-COOH;COOH-CH2-PEG5-OCH2COOH;PEG6-(CH2CO2H)2, 10 mM in DMSO;3,6,9,12,15,18-hexaoxaicosanedioic acid;3,6,9,12,15,18-Hexaoxaeicosanedioic acid;3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid;HOOCCH2O-PEG5-CH2COOH/3,6,9,12,15,18-Hexaoxaeicosanedioic acid
CBNumber
CB13163101
Molecular Formula
C14H26O10
Formula Weight
354.35
MOL File
77855-76-6.mol
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PEG6-(CH2CO2H)2 Property

Boiling point:
524.8±45.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
Store at Room Tem.
solubility 
Soluble in Water
pka
3.09±0.10(Predicted)
form 
Oil
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23337
Product name
PEG6-(CH2CO2H)2
Purity
98%
Packaging
250mg
Price
$350
Updated
2021/12/16
Activate Scientific
Product number
AS104218
Product name
HOOCCH2O-PEG5-CH2COOH
Purity
95+%
Packaging
1g
Price
$471
Updated
2021/12/16
BroadPharm
Product number
BP-23337
Product name
PEG6-(CH2CO2H)2
Purity
98%
Packaging
500mg
Price
$480
Updated
2021/12/16
BroadPharm
Product number
BP-23337
Product name
PEG6-(CH2CO2H)2
Purity
98%
Packaging
1g
Price
$780
Updated
2021/12/16
BroadPharm
Product number
BP-23337
Product name
PEG6-(CH2CO2H)2
Purity
98%
Packaging
5G
Price
$1900
Updated
2021/12/16
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PEG6-(CH2CO2H)2 Chemical Properties,Usage,Production

Description

PEG6-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1].

IC 50

PEGs

References

[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1

PEG6-(CH2CO2H)2 Preparation Products And Raw materials

Raw materials

Preparation Products

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77855-76-6, PEG6-(CH2CO2H)2Related Search:

3,6-DIOXAOCTANEDIOIC ACID BETA-ESTRADIOL 17-ACETATE BUPIRIMATE HOOCCH2O-PEG7-CH2COOH HOOCCH2O-PEG6-CH2COOH HOOCCH2O-PEG10-CH2COOH CH2COOH-PEG12-CH2COOH Diglycolic acid HOOCCH2O-PEG8-CH2COOH Peg6-(ch2co2t-butyl)2 Azido-PEG1-CH2CO2tBu Azido-PEG4-t-butyl acetate Bromo-PEG2-CH2CO2tBu Hydroxy-PEG6-CH2CO2tBu 3,6,9-TRIOXAUNDECANEDIOIC ACID PEG5-(CH2CO2H)2 [1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]-bis- COOH-CH2-PEG10-CH2-COOH

  • PEG6-(CH2CO2H)2
  • HOOCCH2O-PEG5-CH2COOH
  • 3,6,9,12,15,18-Hexaoxaeicosanedioic acid
  • CAS_77855-76-6
  • COOH-CH2-PEG5-CH2-COOH
  • 3,6,9,12,15,18-hexaoxaicosanedioic acid
  • 3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid
  • PEG6 (CH2CO2H)2,PROTAC Linkers,PEG-6-(CH2CO2H)2,PEG6-(CH2CO2H)2,PEG6(CH2CO2H)2,inhibit,Inhibitor
  • HOOCCH2O-PEG5-CH2COOH/3,6,9,12,15,18-Hexaoxaeicosanedioic acid
  • PEG6-(CH2CO2H)2, 10 mM in DMSO
  • COOH-CH2-PEG5-OCH2COOH
  • 77855-76-6
  • PROTAC LINKER