Azido-PEG4-t-butyl acetate
- Product Name
- Azido-PEG4-t-butyl acetate
- CAS No.
- 864681-04-9
- Chemical Name
- Azido-PEG4-t-butyl acetate
- Synonyms
- CAS_864681-04-9;Azido-PEG4-CH2-Boc;Azido-PEG4-CH2COOtBu;Azido-PEG4-t-butyl acetate;Azido-PEG4-CH2COOH t-Bu Ester;TERT-BUTYL 14-AZIDO-3,6,9,12-TETRAOXATETRADECANOATE;tert-Butyl 14-Azido-3,6,9,12-tetraoxatetradecan-1-oate;N3-PEG4-CH2COOtBu/3,6,9,12-Tetraoxatetradecanoic acid, 14-azido-, 1,1-dimethylethyl ester
- CBNumber
- CB83062205
- Molecular Formula
- C14H27N3O6
- Formula Weight
- 333.38068
- MOL File
- 864681-04-9.mol
Azido-PEG4-t-butyl acetate Property
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- bp-22105
- Product name
- Azido-PEG4-CH2CO2-t-Bu
- Purity
- 98%
- Packaging
- 500MG
- Price
- $140
- Updated
- 2026/05/24
- Product number
- bp-22105
- Product name
- Azido-PEG4-CH2CO2-t-Bu
- Purity
- 98%
- Packaging
- 1G
- Price
- $250
- Updated
- 2026/05/24
- Product number
- bp-22105
- Product name
- Azido-PEG4-CH2CO2-t-Bu
- Purity
- 98%
- Packaging
- 5G
- Price
- $650
- Updated
- 2026/05/24
- Product number
- AA00IE0A
- Product name
- tert-Butyl 14-azido-3,6,9,12-tetraoxatetradecanoate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2026/05/29
- Product number
- AA00IE0A
- Product name
- tert-Butyl 14-azido-3,6,9,12-tetraoxatetradecanoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $112
- Updated
- 2026/05/29
Azido-PEG4-t-butyl acetate Chemical Properties,Usage,Production
Description
Azido-PEG4-CH2CO2-t-butyl ester is a PEG reagent containing an azide group and a t-butyl protected carboxyl group. The azide group enables Click Chemistry. The protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. t-butyl ester can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Alkyl/ether; Cleavable Linker
References
[1] Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1.
[2] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228
Azido-PEG4-t-butyl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG4-t-butyl acetate Suppliers
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 40000
- Advantage
- 60
- Tel
- 0431-80534353 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 3855
- Advantage
- 55
- Tel
- 027-65563561
- Fax
- 86-27-59218822
- sales@borenpharm.com
- Country
- China
- ProdList
- 1245
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 89686
- Advantage
- 60
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10021
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28769
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 18668996177
- linkingpharm@126.com
- Country
- China
- ProdList
- 55
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32466
- Advantage
- 58
View Lastest Price from Azido-PEG4-t-butyl acetate manufacturers
- Product
- N3-PEG4-CH2COOtBu 864681-04-9
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-04