SPDP-PEG8-acid

Product Name: SPDP-PEG8-acid
CAS No.: 1334177-96-6
Chemical Name: SPDP-PEG8-acid
Synonyms: SDPD-PEG8-COOH;SPDP-PEG8-acid;SPDP-PEG8-COOH;Opss-peg(8)-cooh;3-Oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid;Propanoic acid, 3-[[25-oxo-27-(2-pyridinyldithio)-3,6,9,12,15,18,21-heptaoxa-24-azaheptacos-1-yl]oxy]-
CBNumber: CB13163141
Molecular Formula: C27H46N2O11S2
Formula Weight: 638.79094
MOL File: 1334177-96-6.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: S679905
Product name: SPDP-PEG8-acid
Packaging: 50mg
Price: $200
Updated: 2021/12/16

TRC

Product number: S679905
Product name: SPDP-PEG8-acid
Packaging: 100mg
Price: $310
Updated: 2021/12/16

BroadPharm

Product number: BP-21940
Product name: SPDP-PEG8-acid
Purity: 98%
Packaging: 100mg
Price: $380
Updated: 2021/12/16

dPEG

Product number: 10375
Product name: SPDP-dPEG®₈-acid
Packaging: 1000mg
Price: $600
Updated: 2021/12/16

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SPDP-PEG8-acid Chemical Properties,Usage,Production

Description

SPDP-PEG8-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.

Uses

OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

SPDP-PEG8-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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SPDP-PEG8-acid Suppliers

China 24 India 1 United States 2 Global 27

Bide Pharmatech Ltd.

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View Lastest Price from SPDP-PEG8-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: SPDP-PEG8-COOH 1334177-96-6
Price: US $0.00/mg
Min. Order: 500mg
Purity: >98.00%
Supply Ability: 500mg
Release date: 2024-03-27

1334177-96-6, SPDP-PEG8-acidRelated Search:

SPDP Py-2H-Tetrazine-Py-NHBoc Py-2H-Tetrazine-Py-NH2TFA SPDP-Val-Cit-PAB-PNP SPDP-Val-Cit-PAB-OH SPDP-PEG2-NHS ester SPDP-PEG9-COOH SPDP-PEG2-COOH Acrylamide SPDP-PEG4-NHS ester SPDP-dPEG(R)12-NHS ester SPDP-PEG8-NHS ester SPDP-PEG4-acid

SPDP-PEG8-acid

SDPD-PEG8-COOH

Opss-peg(8)-cooh

SPDP-PEG8-COOH

Propanoic acid, 3-[[25-oxo-27-(2-pyridinyldithio)-3,6,9,12,15,18,21-heptaoxa-24-azaheptacos-1-yl]oxy]-

3-Oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid

1334177-96-6

C27H46N2O11S2

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