2-IODO-3-HYDROXYPYRIDINE
- Product Name
- 2-IODO-3-HYDROXYPYRIDINE
- CAS No.
- 40263-57-8
- Chemical Name
- 2-IODO-3-HYDROXYPYRIDINE
- Synonyms
- 2-iodpyridin-3-ol;2-IODOPYRIDIN-3-OL;2-Iodopyridine-3-ol;3-Pyridinol, 2-iodo-;2-IODO-3-HYDROXYPYRIDINE;3-HYDROXY-2-IODOPYRIDINE;2-HYDROXY-3-IODOPYRIDINE;2-lodo-3-hydroxypyridine;3-Hydroxy-2-iodopyridine>Pyridine, 2-iodo-3-hydroxy-
- CBNumber
- CB1327625
- Molecular Formula
- C5H4INO
- Formula Weight
- 221
- MOL File
- 40263-57-8.mol
2-IODO-3-HYDROXYPYRIDINE Property
- Melting point:
- 193-195°C
- Boiling point:
- 296.6±20.0 °C(Predicted)
- Density
- 2.142±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.74±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to tan
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Light Sensitive
- BRN
- 109836
- InChI
- InChI=1S/C5H4INO/c6-5-4(8)2-1-3-7-5/h1-3,8H
- InChIKey
- HJBGMPCMSWJZNH-UHFFFAOYSA-N
- SMILES
- C1(I)=NC=CC=C1O
- CAS DataBase Reference
- 40263-57-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 675873
- Product name
- 2-Iodo-3-hydroxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $80.2
- Updated
- 2023/01/07
- Product number
- H1396
- Product name
- 3-Hydroxy-2-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- HCH0011693
- Product name
- 2-IODO-3-HYDROXY PYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $635.71
- Updated
- 2021/12/16
- Product number
- HCH0011693
- Product name
- 2-IODO-3-HYDROXY PYRIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $896.28
- Updated
- 2021/12/16
- Product number
- HCH0011693
- Product name
- 2-IODO-3-HYDROXY PYRIDINE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1534.3
- Updated
- 2021/12/16
2-IODO-3-HYDROXYPYRIDINE Chemical Properties,Usage,Production
Uses
2-Iodo-3-hydroxypyridine acts as a reagent in the synthesis of the differentiating antibiotic azatyrosine
Synthesis
109-00-2
40263-57-8
General procedure for the synthesis of 2-iodo-3-hydroxypyridine using 3-hydroxypyridine as starting material: sodium carbonate (Na2CO3, 11.6 g, 109.72 mmol) and iodine (I2, 13.3 g, 52.57 mmol) were added sequentially to a solution of 3-hydroxypyridine (5.0 g, 52.57 mmol) in water (400 mL). The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the pH was adjusted to 4 with 1 M hydrochloric acid (HCl) solution. the precipitate was collected by filtration, washed with cold water and dried to give 2-iodo-3-hydroxypyridine (10.7 g, 92% yield) as a white powder. The product characterization data were as follows: melting point 189-190 °C (neat); thin layer chromatography (TLC) Rf = 0.33 (unfolding reagent dichloromethane/ethanol, 97/3, v/v); infrared spectroscopy (IR, KBr pressed) νmax (cm-1): 2851, 2722, 2573, 2345, 1560, 1455, 1301, 1189, 1121, 794, 668; nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ10.88 (s, 1H, OH), 7.87 (dd, 1H, J1 = 1.6 Hz, J2 = 4.4 Hz, H-6), 7.24 (dd, 1H, J1 = 4.4 Hz, J2 = 8.0 Hz, H-5), 7.18 (dd, 1H, J1 = 1.6 Hz, J2 = 8.0 Hz, H-4); nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6): δ 154.0, 141.8, 124.3, 121.3, 110.9; high resolution mass spectrometry (HRMS) calculated value of C5H4INO [M + H]+ 221.9410, measured value 221.9416.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 8, p. 944 - 947
[2] Tetrahedron, 2017, vol. 73, # 41, p. 6000 - 6007
[3] Patent: CN107793420, 2018, A. Location in patent: Paragraph 0009
[4] Roczniki Chemii, 1936, vol. 16, p. 502,507
[5] Chem. Zentralbl., 1937, vol. 108, # I, p. 3634
2-IODO-3-HYDROXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-IODO-3-HYDROXYPYRIDINE Suppliers
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- South Korea
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View Lastest Price from 2-IODO-3-HYDROXYPYRIDINE manufacturers
- Product
- 2-IODO-3-HYDROXYPYRIDINE 40263-57-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 2-IODO-3-HYDROXYPYRIDINE 40263-57-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-IODO-3-HYDROXYPYRIDINE 40263-57-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11