5-Amino-2,4,6-triiodoisophthalic acid
- Product Name
- 5-Amino-2,4,6-triiodoisophthalic acid
- CAS No.
- 35453-19-1
- Chemical Name
- 5-Amino-2,4,6-triiodoisophthalic acid
- Synonyms
- ATIPA;5-AMino-2;Iohexol Impurity 8; Iohexol Impurity K;5-Amino-2,4,6-triiod;5-Amino-2,4,6-triiodo;Iohexol EP impurity K;Aminoiodoisophthalicacid;6-triiodoisophthalic acid;5-Amino-2,4,6-triiodoisophthaL
- CBNumber
- CB1329018
- Molecular Formula
- C8H4I3NO4
- Formula Weight
- 558.84
- MOL File
- 35453-19-1.mol
5-Amino-2,4,6-triiodoisophthalic acid Property
- Melting point:
- 265-270 °C (lit.)
- Boiling point:
- 539.4±50.0 °C(Predicted)
- Density
- 3.053±0.06 g/cm3(Predicted)
- vapor pressure
- 10hPa at 20℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- pka
- 0.83±0.10(Predicted)
- color
- Beige
- InChI
- InChI=1S/C8H4I3NO4/c9-3-1(7(13)14)4(10)6(12)5(11)2(3)8(15)16/h12H2,(H,13,14)(H,15,16)
- InChIKey
- JEZJSNULLBSYHV-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=C(I)C(N)=C(I)C(C(O)=O)=C1I
- CAS DataBase Reference
- 35453-19-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 29224995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 444367
- Product name
- 5-Amino-2,4,6-triiodoisophthalic acid
- Purity
- 95%
- Packaging
- 50g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- A1406
- Product name
- 5-Amino-2,4,6-triiodoisophthalic Acid
- Purity
- >96.0%(T)
- Packaging
- 25g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- A630810
- Product name
- 5-Amino-2,4,6-triiodoisophthalic acid
- Packaging
- 250g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- FA00843
- Product name
- 5-Amino-2,4,6-triiodoisophthalic acid
- Packaging
- 500g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FA00843
- Product name
- 5-Amino-2,4,6-triiodoisophthalic acid
- Packaging
- 100g
- Price
- $85
- Updated
- 2021/12/16
5-Amino-2,4,6-triiodoisophthalic acid Chemical Properties,Usage,Production
Chemical Properties
Beige Solid
Uses
5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.
Uses
Intermediate for nonionic iodinated X-ray contrast agents.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
99-31-0
35453-19-1
Example 1 Synthesis of 5-amino-2,4,6-triiodoisophthalic acid In a 250 mL three-necked round-bottomed flask equipped with a thermometer, condenser, and magnetic stirrer, 5-aminoisophthalic acid (I) (3.86 g, 27.6 mmol) was dissolved in water (129.42 g), and pH was adjusted with 96% sulfuric acid (2 mL, 35.3 mmol) to 1. Subsequently, solid iodine (8.42 g, 33.2 mmol) was added, and the mixture was heated to 72 °C in an oil bath. An 18.65% (w/v) aqueous iodic acid solution (20 mL, 21.2 mmol) was slowly added via syringe pump over 5.2 h (addition rate 3.8 mL/h). After continuing the reaction at 72 °C for 1 h (total reaction time 6.2 h), the reaction mixture was cooled to room temperature and filtered. The resulting solid was washed with water and dried to afford 5-amino-2,4,6-triiodoisophthalic acid (II) (12.74 g, 22.8 mmol) as a pale pink solid in 82.6% yield. The product was analyzed by HPLC and compared with the standard to confirm that it meets the analytical specification of industrially produced 5-amino-2,4,6-triiodoisophthalic acid.
References
[1] Patent: EP2243767, 2010, A1. Location in patent: Page/Page column 8
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 19, p. 3611 - 3617
[3] Journal of Organic Chemistry, 1994, vol. 59, # 6, p. 1344 - 1350
[4] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 11, p. 3545 - 3554
[5] Patent: US2820814, 1955,
5-Amino-2,4,6-triiodoisophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-2,4,6-triiodoisophthalic acid Suppliers
- Tel
- --
- Fax
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- unachem@ktnet.co.kr
- Country
- South Korea
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View Lastest Price from 5-Amino-2,4,6-triiodoisophthalic acid manufacturers
- Product
- 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-19
- Product
- 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-26
- Product
- 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
- Price
- US $181.39/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.50%HPLC
- Supply Ability
- 3tons/month
- Release date
- 2021-09-16