ChemicalBook > CAS DataBase List > 3,5-Dibromopyridine

3,5-Dibromopyridine

Product Name
3,5-Dibromopyridine
CAS No.
625-92-3
Chemical Name
3,5-Dibromopyridine
Synonyms
NSC 6209;3,5-Dibrompyridin;IFLAB-BB F1995-0190;3,5-DIBROMOPYRIDINE;3,5-dibormopyridine;TIMTEC-BB SBB003237;Pyridine, 3,5-dibromo-;3,5-Dibromopyridine>Perampanel Impurity 12;3,5-Dibromopyridine,99%
CBNumber
CB1333488
Molecular Formula
C5H3Br2N
Formula Weight
236.89
MOL File
625-92-3.mol
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3,5-Dibromopyridine Property

Melting point:
110-115 °C (lit.)
Boiling point:
222 °C
Density 
2.0383 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
pka
0.52±0.20(Predicted)
form 
Needle-Like Crystals
color 
White to light beige
Water Solubility 
Soluble in Chloroform and Methanol. Insoluble in water.
BRN 
108477
InChIKey
SOSPMXMEOFGPIM-UHFFFAOYSA-N
CAS DataBase Reference
625-92-3(CAS DataBase Reference)
NIST Chemistry Reference
3,5-Dibromopyridine(625-92-3)
EPA Substance Registry System
3,5-Dibromopyridine (625-92-3)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
120162
Product name
3,5-Dibromopyridine
Purity
99%
Packaging
10g
Price
$55.6
Updated
2024/03/01
TCI Chemical
Product number
D2573
Product name
3,5-Dibromopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
D2573
Product name
3,5-Dibromopyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$179
Updated
2024/03/01
Alfa Aesar
Product number
A10875
Product name
3,5-Dibromopyridine, 98+%
Packaging
5g
Price
$62.65
Updated
2024/03/01
Alfa Aesar
Product number
A10875
Product name
3,5-Dibromopyridine, 98+%
Packaging
25g
Price
$256.65
Updated
2024/03/01
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3,5-Dibromopyridine Chemical Properties,Usage,Production

Chemical Properties

Light-Yellow Solid

Uses

3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3?-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

Definition

ChEBI: 3,5-dibromopyridine is a dibromopyridine.

Application

3,5-Dibromopyridine (3,5-DBP) can be used for:
(1) Spectroscopic analysis: FTIR and FT Raman spectra in the solid phase of 3,5-DBP and 3,5- dichloro-2,4,6-trifluoropyridine (3,5-DCTFP) were recorded in the regions of 4000-400 cm-1 and 3500-100 cm-1, respectively[1].
(2) Chemical reactions: 3,5-DBP can be reacted with phenyl isocyanate. chemoselective Staudinger-Phosphite reaction of 2,4,6-triazido-3,5-dibromopyridine azide moiety[2-3].
(3) Organic synthesis: Using 3,5-dibromopyridine as raw material can be used to prepare 3-acetamido-5-ethoxypyridine[4].

General Description

3,5-Dibromopyridine undergoes lithiation with lithium diisopropylamide and on subsequent reaction with electrophiles yields 4-alkyl-3,5-dibromopyridines.

References

[1] V. KRISHNAKUMAR  R. J X. Density functional theory calculations and vibrational spectra of 3,5-dibromopyridine and 3,5-dichloro-2,4,6-trifluoropyridine[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005. DOI:10.1016/j.saa.2004.03.038.
[2] SERGEI V. CHAPYSHEV Igor K Y Alexander V Chernyak. Chemoselective Staudinger-Phosphite Reaction on the Azido Groups of 2,4,6-Triazido-3,5-dibromopyridine[J]. Journal of Heterocyclic Chemistry, 2015. DOI:10.1002/jhet.2339.
[3] T. HISANO M. I Toshikazu Matsuoka. THE REACTION OF 3,5-DIBROMOPYRIDINE N-OXIDE WITH PHENYL ISOCYANATE[J]. ChemInform, 1974. DOI:10.1002/CHIN.197448358.
[4] H. J. HERTOG  A. V D L A W M Falter. The reactivity of bromine atoms in brominated pyridines. The preparation of 3-acetylamino-5-ethoxypyridine from 3,5-dibromopyridine?[J]. Recueil des Travaux Chimiques des Pays-Bas, 1948. DOI:10.1002/RECL.19480670507.

3,5-Dibromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

5-Bromo-2-fluoro-3-methoxypyridine 5-(BENZYLOXY)PYRIDIN-3-AMINE 3-Amino-5-hydroxypyridine 5-methoxypyridin-3-amine 3-(BENZYLOXY)-5-BROMOPYRIDINE 5-Bromopyridine-3-boronic acid 3-Amino-5-bromopyridine 5-METHOXY-PYRIDINE-3-CARBALDEHYDE
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View Lastest Price from 3,5-Dibromopyridine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
3,5-Dibromopyridine 625-92-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
3,5-Dibromopyridine 625-92-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-20
Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-Dibromopyridine 625-92-3
Price
US $8.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28

625-92-3, 3,5-DibromopyridineRelated Search:

2-Chloro-3-cyanopyridine 2,2-Bis(bromomethyl)propane-1,3-diol 2,3-Dibromopropionic acid 2,5-DIBROMOPYRIDINE 2,5-DIBROMOPYRIDINE,2,5-DIBROMOPYRIDINE 1,3-Dibromo-5,5-dimethylhydantoin 1,2-Dibromopropane 3-Aminopyridine 2,4-DIBROMOPENTANE 2-PHENYL-1,3,2-DIOXABORINANE PeraMpanel PeraMpanel 6'-Methoxy-2,3'-bipyridine PeraMpanel PeraMpanel PeraMpanel 2-Cyanophenylboronic acid Phenylboronic acid 3,5-Dimethoxypyridine

  • 3,5-DIBROMOPYRIDINE
  • IFLAB-BB F1995-0190
  • 3,5-Dibromopyridine,99%
  • 3,5-Dibromopyridine, 98+%
  • 3,5-dibormopyridine
  • 3,5-DibroMopyridine, 97+%
  • 3, 5-2 broMide pyridine
  • 3,5-Dibromopyridine 99%
  • 3,5-DibroMopyridine, 98+% 25GR
  • NSC 6209
  • 3,5-DIBROMOPYRIDINE FOR SYNTHESIS
  • Pyridine, 3,5-dibromo-
  • TIMTEC-BB SBB003237
  • 3,5-Dibromopyridine&gt
  • Perampanel Impurity 12
  • 3,5-Dibromopyridine ISO 9001：2015 REACH
  • Pyronoprene Impurity 15
  • 3,5-Dibrompyridin
  • 625-92-3
  • 625-72-3
  • C5H3Br2N
  • C5H3NBr2
  • C5H3BrN2
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Building Blocks
  • Bromopyridines
  • Halopyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • C5Heterocyclic Building Blocks
  • Brominated heterocyclic series
  • Boronate Ester
  • Boronic Acid
  • Potassium Trifluoroborate
  • Pyridines derivates
  • API intermediates
  • Halogenated
  • Organohalides
  • Aromatics Compounds
  • Bromopyridines
  • Halopyridines
  • Aromatics
  • Bases & Related Reagents
  • Nucleotides
  • blocks
  • Bromides
  • Pyridines
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • bc0001
  • 1
  • 625-92-3