3,5-Dibromopyridine
- Product Name
- 3,5-Dibromopyridine
- CAS No.
- 625-92-3
- Chemical Name
- 3,5-Dibromopyridine
- Synonyms
- NSC 6209;3,5-Dibrompyridin;IFLAB-BB F1995-0190;3,5-DIBROMOPYRIDINE;3,5-dibormopyridine;TIMTEC-BB SBB003237;Pyridine, 3,5-dibromo-;3,5-Dibromopyridine>Perampanel Impurity 12;3,5-Dibromopyridine,99%
- CBNumber
- CB1333488
- Molecular Formula
- C5H3Br2N
- Formula Weight
- 236.89
- MOL File
- 625-92-3.mol
3,5-Dibromopyridine Property
- Melting point:
- 110-115 °C (lit.)
- Boiling point:
- 222 °C
- Density
- 2.0383 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- 0.52±0.20(Predicted)
- form
- Needle-Like Crystals
- color
- White to light beige
- Water Solubility
- Soluble in Chloroform and Methanol. Insoluble in water.
- BRN
- 108477
- InChIKey
- SOSPMXMEOFGPIM-UHFFFAOYSA-N
- CAS DataBase Reference
- 625-92-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,5-Dibromopyridine(625-92-3)
- EPA Substance Registry System
- 3,5-Dibromopyridine (625-92-3)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- RIDADR
- UN2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 120162
- Product name
- 3,5-Dibromopyridine
- Purity
- 99%
- Packaging
- 10g
- Price
- $55.6
- Updated
- 2024/03/01
- Product number
- D2573
- Product name
- 3,5-Dibromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $61
- Updated
- 2024/03/01
- Product number
- D2573
- Product name
- 3,5-Dibromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- A10875
- Product name
- 3,5-Dibromopyridine, 98+%
- Packaging
- 5g
- Price
- $62.65
- Updated
- 2024/03/01
- Product number
- A10875
- Product name
- 3,5-Dibromopyridine, 98+%
- Packaging
- 25g
- Price
- $256.65
- Updated
- 2024/03/01
3,5-Dibromopyridine Chemical Properties,Usage,Production
Chemical Properties
Light-Yellow Solid
Uses
3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3?-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.
Definition
ChEBI: 3,5-dibromopyridine is a dibromopyridine.
Application
3,5-Dibromopyridine (3,5-DBP) can be used for:
(1) Spectroscopic analysis: FTIR and FT Raman spectra in the solid phase of 3,5-DBP and 3,5- dichloro-2,4,6-trifluoropyridine (3,5-DCTFP) were recorded in the regions of 4000-400 cm-1 and 3500-100 cm-1, respectively[1].
(2) Chemical reactions: 3,5-DBP can be reacted with phenyl isocyanate. chemoselective Staudinger-Phosphite reaction of 2,4,6-triazido-3,5-dibromopyridine azide moiety[2-3].
(3) Organic synthesis: Using 3,5-dibromopyridine as raw material can be used to prepare 3-acetamido-5-ethoxypyridine[4].
General Description
3,5-Dibromopyridine undergoes lithiation with lithium diisopropylamide and on subsequent reaction with electrophiles yields 4-alkyl-3,5-dibromopyridines.
References
[1] V. KRISHNAKUMAR R. J X. Density functional theory calculations and vibrational spectra of 3,5-dibromopyridine and 3,5-dichloro-2,4,6-trifluoropyridine[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005. DOI:10.1016/j.saa.2004.03.038.
[2] SERGEI V. CHAPYSHEV Igor K Y Alexander V Chernyak. Chemoselective Staudinger-Phosphite Reaction on the Azido Groups of 2,4,6-Triazido-3,5-dibromopyridine[J]. Journal of Heterocyclic Chemistry, 2015. DOI:10.1002/jhet.2339.
[3] T. HISANO M. I Toshikazu Matsuoka. THE REACTION OF 3,5-DIBROMOPYRIDINE N-OXIDE WITH PHENYL ISOCYANATE[J]. ChemInform, 1974. DOI:10.1002/CHIN.197448358.
[4] H. J. HERTOG A. V D L A W M Falter. The reactivity of bromine atoms in brominated pyridines. The preparation of 3-acetylamino-5-ethoxypyridine from 3,5-dibromopyridine?[J]. Recueil des Travaux Chimiques des Pays-Bas, 1948. DOI:10.1002/RECL.19480670507.
3,5-Dibromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dibromopyridine manufacturers
- Product
- 3,5-Dibromopyridine 625-92-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 1000
- Release date
- 2025-01-20
- Product
- 3,5-Dibromopyridine 625-92-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-30
- Product
- 3,5-Dibromopyridine 625-92-3
- Price
- US $8.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28