Etelcalcetide HCl

Product Name: Etelcalcetide HCl
CAS No.: 1334237-71-6
Chemical Name: Etelcalcetide HCl
Synonyms: AMG416;AMG 416;Parsabiv;KAI-4169;Etelcalcetide HCl;AMG 416 hydrochloride;KAI-4169 hydrochloride;1262780-97-1 (free base);Vicosidine hydrochloride;velcalcetide hydrochloride
CBNumber: CB13339874
Molecular Formula: C38H74ClN21O10S2
Formula Weight: 1084.71186
MOL File: 1334237-71-6.mol

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Etelcalcetide HCl Property

storage temp.: Store at -20°C
solubility: DMSO:10.0(Max Conc. mg/mL);8.37(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);8.37(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);41.87(Max Conc. mM)
form: A crystalline solid
color: White to off-white
Sequence: Ac-d-Cys（Cys）-d-Ala-d-Arg-d-Arg-d-Arg-d-Ala-d-Arg-NH2 (Disulfide bridge: Cys-Cys)
InChIKey: CRSDUYHPKJMYMG-KZTORMJDNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26901
Product name: Etelcalcetide (hydrochloride)
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 26901
Product name: Etelcalcetide (hydrochloride)
Packaging: 10mg
Price: $319
Updated: 2024/03/01

Cayman Chemical

Product number: 26901
Product name: Etelcalcetide (hydrochloride)
Packaging: 5mg
Price: $169
Updated: 2024/03/01

ChemScene

Product number: CS-0103197
Product name: Etelcalcetidehydrochloride
Purity: 99.31%
Packaging: 10mg
Price: $260
Updated: 2021/12/16

ChemScene

Product number: CS-0103197
Product name: Etelcalcetidehydrochloride
Purity: 99.31%
Packaging: 1mg
Price: $55
Updated: 2021/12/16

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Etelcalcetide HCl Chemical Properties,Usage,Production

Uses

Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].

in vivo

Etelcalcetide hydrochloride (2.5 μg/h and 20 μg/h, infusion, 3 days) significantly reduces plasma PTH concentrations and decreased the renal expression of Cyp24a1 with a higher delivery rate^[1].

Animal Model:	C57BL7/6J male mice
Dosage:	2.5 μg/h and 20 μg/h
Administration:	infusion, 3 days
Result:	Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 μg/h, but decreased the renal expression of Cyp24a1 with 20 μg/h ^[1]

References

[1] Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1 DOI:10.1016/j.ebiom.2022.103947
[2] Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39(3):396-403. DOI:10.1007/s00774-020-01158-2

Etelcalcetide HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Etelcalcetide HCl Suppliers

China 62 China Hong Kong 1 India 3 United States 5 Global 71

Suzhou Tianma Pharma Group Tianji Bio-Pharmaceutical Co., Ltd.

Tel: 0512-68322275 15850786624
Email: danielzhao@tianmapharma.com
Country: China
ProdList: 30
Advantage: 58

Hangzhou Peptide Biochem Co.,Ltd

Tel: 0571-89197072; 18668118770
Fax: 0571-89197072
Email: linda@peptide-china.com
Country: China
ProdList: 235
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10267
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8618531123677
Email: faithe@yan-xi.com
Country: China
ProdList: 5853
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

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View Lastest Price from Etelcalcetide HCl manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: Etelcalcetide HCl
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-22

Wuhan JiyunZen Tech Co., Ltd.

Product: Etelcalcetide Hydrochloride 1334237-71-6
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-06-05

1334237-71-6, Etelcalcetide HClRelated Search:

Trimethylamine hydrochloride Pyridine hydrochloride Dimethylamine hydrochloride Cysteamine hydrochloride Dipeptide diaminobutyroyl benzylamide diacetate Etelcalcetide Hydrochloride

Etelcalcetide HCl

Etelcalcetide Hydrochloride

Etelcalcetide Hydrochloride (AMG-416)

AMG416

KAI-4169

Parsabiv

velcalcetide hydrochloride

1262780-97-1 (free base)

AMG 416

AMG 416; KAI-4169; VELCALCETIDE HYDROCHLORIDE;PARSABIV;AMG416; 1262780-97-1 (FREE BASE)

AMG 416 hydrochloride

KAI-4169 hydrochloride

Etelcalcetide hydrochloride,KAI-4169,AMG416,KAI4169,CaSR,KAI 4169,AMG 416,inhibit,Etelcalcetide,AMG-416,Inhibitor,Calcium-sensing receptor

S-(((S)-2-Acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-oxopropyl)thio)-L-cysteine hydrochloride (1:X)

Etelcalcetide Pentatrifluoroacetate

Yitka Hydrochloride Peptide

S-(((S)-2-acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-oxopropyl)thio)-L-cysteine hydrochloride

Vicosidine hydrochloride

1334237-71-6