2-Amino-5-chlorobenzophenone
- Product Name
- 2-Amino-5-chlorobenzophenone
- CAS No.
- 719-59-5
- Chemical Name
- 2-Amino-5-chlorobenzophenone
- Synonyms
- (2-AMINO-5-CHLOROPHENYL)(PHENYL)METHANONE;ACB;Alprazolam Impurity 4;4-CHLORO-2-BENZOYLANILINE;2--5-;NSC 84157;2-Amino-5-chloro;IFLAB-BB F1386-0355;TIMTEC-BB SBB003271;Nepafenac Impurity 3
- CBNumber
- CB1335583
- Molecular Formula
- C13H10ClNO
- Formula Weight
- 231.68
- MOL File
- 719-59-5.mol
2-Amino-5-chlorobenzophenone Property
- Melting point:
- 96-98 °C (lit.)
- Boiling point:
- 207 °C
- Density
- 1.33
- vapor pressure
- 0-1Pa at 20-25℃
- refractive index
- 1.6000 (estimate)
- Flash point:
- 211 °C
- storage temp.
- Store below +30°C.
- solubility
- Solubility in methanol gives very faint turbidity. Soluble in DMSO.
- pka
- 0.06±0.10(Predicted)
- form
- Crystalline Powder
- color
- Yellow
- BRN
- 475640
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- ZUWXHHBROGLWNH-UHFFFAOYSA-N
- LogP
- 3.16 at 21℃ and pH7
- CAS DataBase Reference
- 719-59-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzophenone, 2-amino-5-chloro-(719-59-5)
- EPA Substance Registry System
- Methanone, (2-amino-5-chlorophenyl)phenyl- (719-59-5)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22-20/21/22
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- PC4933500
- TSCA
- Yes
- HS Code
- 29223900
- Toxicity
- LD50 orally in Rabbit: 10000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A45564
- Product name
- 2-Amino-5-chlorobenzophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $47.4
- Updated
- 2025/07/31
- Product number
- 1022808
- Product name
- 2-Amino-5-chlorobenzophenone
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- A0079
- Product name
- 2-Amino-5-chlorobenzophenone
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- A0079
- Product name
- 2-Amino-5-chlorobenzophenone
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $545
- Updated
- 2025/07/31
- Product number
- PHR1507
- Product name
- 2-Amino-5-Chlorobenzophenone
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200mg
- Price
- $380
- Updated
- 2025/07/31
2-Amino-5-chlorobenzophenone Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Uses
A metabolite of Diazepam; it had a much weaker anticonvulsant effect.
Uses
It is used in the heterocyclic syntheses based on the reactions of dimethyl acetylenedicarboxylate.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9
General Description
2-Amino-5-chlorobenzophenone is a organic nonlinear optical material.
Synthesis
719-64-2
719-59-5
(2) 10.0 g of intermediate (II) was added to a three-necked flask containing 50 mL of ethanol, 4.8 g of iron powder was added, and refluxed for 0.5 hours. Subsequently, 1 mL of 6 mol/L sulfuric acid solution was slowly added dropwise. After the dropwise addition, the reaction was continued to reflux for 1 hour. After the reaction was completed, the pH of the reaction solution was adjusted to 8 with NaOH solution and cooled to 50 °C. Add 0.2 g of activated carbon and reflux for 0.5 h. Perform hot filtration into a crystallization flask and cool the crystals. The crystals were washed with ethanol and dried to give 9.60 g of intermediate (III) in 95.1% yield, melting point 96.3-98.2 °C.
References
[1] Journal of Chemical Research - Part S, 2002, # 12, p. 601 - 603
[2] Patent: CN108250091, 2018, A. Location in patent: Paragraph 0032; 0034; 0040
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 690 - 691
[4] Patent: CN106083621, 2016, A. Location in patent: Paragraph 0021-0025
[5] Patent: CN107935872, 2018, A. Location in patent: Paragraph 0034-0063; 0067-0074
2-Amino-5-chlorobenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-5-chlorobenzophenone Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
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- 6700
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View Lastest Price from 2-Amino-5-chlorobenzophenone manufacturers
- Product
- 2-Amino-5-chlorobenzophenone 719-59-5
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1KG 100KG 1MT
- Release date
- 2025-05-19
- Product
- 2-Amino-5-chlorobenzophenone 719-59-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-25
- Product
- 2-Amino-5-chlorobenzophenone 719-59-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-03