Betamethasone 21-acetate

ChemicalBook > CAS DataBase List > Betamethasone 21-acetate

Betamethasone 21-acetate

Product Name: Betamethasone 21-acetate
CAS No.: 987-24-6
Chemical Name: Betamethasone 21-acetate
Synonyms: BETAMETHASONE ACETATE;Betamethasone 21-ace;Betamethasone 21-Acetata;BETAMETHASONE 21-ACETATE;Betamethasone acetate CRS;Betamethasone Acetate API;Betamethasone21-acetatemicro;Betamethasone Acetate (500 mg);C10575005 BetamethasonEacetate;BETAMETHASONE ACETATE LINIMENTS
CBNumber: CB1337284
Molecular Formula: C24H31FO6
Formula Weight: 434.5
MOL File: 987-24-6.mol

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Betamethasone 21-acetate Property

Melting point:: 200-220°C (dec.)
alpha: D +140° (chloroform)
Boiling point:: 579.4±50.0 °C(Predicted)
Density: 1.0932 (rough estimate)
refractive index: 1.5980 (estimate)
storage temp.: Refrigerator
solubility: Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka: 12.08±0.70(Predicted)
color: White to Off-White
Water Solubility: 30mg/L(25 ºC)
Merck: 14,1180
CAS DataBase Reference: 987-24-6(CAS DataBase Reference)
EPA Substance Registry System: .beta.-Methasone acetate (987-24-6)

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Safety

Hazard Codes: Xn
Risk Statements: 40
Safety Statements: 22-36
WGK Germany: 3
HS Code: 2937220000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1779
Product name: Betamethasone acetate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $267
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1067001
Product name: Betamethasone acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: B1030000
Product name: Betamethasone acetate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: b1030000
Price: $220
Updated: 2024/03/01

TRC

Product number: B327025
Product name: Betamethasone21-Acetate
Packaging: 1g
Price: $1185
Updated: 2021/12/16

TRC

Product number: B327025
Product name: Betamethasone21-Acetate
Packaging: 5mg
Price: $95
Updated: 2021/12/16

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Betamethasone 21-acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Celestone Soluspan,Schering,US,1965

Uses

Betamethasone acetate (BA)

Uses

amino acid, nutrient

Uses

CORTICOSTEROID

Definition

ChEBI: Betamethasone acetate is an acetate ester, a steroid ester, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone.

Manufacturing Process

The synthesis is long and complex. For brevity, only the last steps are given here. Refer to the patents cited below for full details.
Preparation of 9α-Bromo-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a mixture of 620 mg of 17α,21-dihydroxy-16β-methyl- 4,9(11)-pregnadiene-3,20-dione 21-acetate and 330 mg of Nbromosuccinimide in 10 ml of dioxane and 3.2 ml of water cooled to 10°C was added 1.8 ml of cold 1 M aqueous perchloric acid. The mixture was stirred at 15°C for 3 hours. Excess N-bromosuccinimide was destroyed by addition of aqueous sodium thiosulfate and most of the dioxane was removed in vacuo. About 30 ml of water was added and crystalline bromohydrin, 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate, was filtered, washed with water, and dried in air. Preparation of 9β,11β-Epoxy-17α-21-Dihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a stirred solution of 100 mg of the 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of 0.215N methanolic sodium methoxide. After 10 minutes at 25°C, 0.2 ml of acetic acid was added and the methanol removed in vacuo. The residue was acetylated with 1.00 ml of pyridine and 0.5 ml of acetic anhydride at 60°C for 70 minutes. The mixture was taken to dryness in vacuo, water added, and the product extracted into chloroform. The residue was crystallized from etheracetone to give pure 9β,11β-epoxy-17α,21-dihydroxy-16β-methyl-4-pregnene- 3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a solution of 200 mg of 9β,11β-epoxy-17α,21-dihydroxy- 16β-methyl-4-pregnene-3,20-dione 21-acetate in 2 ml of chloroform and 2 ml of tetrahydrofuran in a polyethylene bottle at -60°C was added 2 ml of a 2:1 (by weight) mixture of anhydrous hydrogen fluoride and tetrahydrofuran. After 4 hours at -10°C the mixture was cooled to -60°C and cautiously added to a stirred mixture of 30 ml or 25% aqueous potassium carbonate and 25 ml of chloroform kept at -5°C. The aqueous phase was further extracted with chloroform and the latter phase washed with water and dried over magnesium sulfate. The residue on crystallization from acetone-ether gave pure 9α-fluoro- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnadiene- 3,20-Dione 21-Acetate 100 mg of 9α-fluoro-11β,17α,21-trihydroxy-16β- methyl-4-pregnene-3,20-dione 21-acetate was treated with selenium dioxide to produce the corresponding 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-4- pregnadiene-3,20-dione 21-acetate. Alternately, Bacillus sphaericus may be utilized.

Therapeutic Function

Glucocorticoid

Betamethasone 21-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Betamethasone

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View Lastest Price from Betamethasone 21-acetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Betamethasone 21-acetate/Betamethasone Acetate 987-24-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000
Release date: 2023-07-27

Hebei Weibang Biotechnology Co., Ltd

Product: Betamethasone 21-acetate 987-24-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Fengqiang Trading Co., LTD

Product: Betamethasone 21-acetate 987-24-6
Price: US $100.00/bag
Min. Order: 1bag
Purity: 99
Supply Ability: 5000
Release date: 2023-09-01

987-24-6, Betamethasone 21-acetateRelated Search:

Methylparaben Ammonium acetate Benzyl acetate Tris(hydroxymethyl)aminomethane Magnesium acetate Vinyl acetate Methanol Betamethasone 21-phosphate disodium Basic Violet 1 Methyl acrylate Betamethasone 17-valerate Sodium acetate Betamethasone Allyl methacrylate METHYLCYCLOPENTADIENE DIMER Cellulose acetate Butyl acetate BETAMETHASONE DIPROPIONATE MM(CRM STANDARD)

9alpha-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate

(11β,16β)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione

BETAMETHASONE ACETATE LINIMENTS

(17R)-16β-Methyl-21-acetoxy-11β,17α-dihydroxy-9α-fluoropregna-1,4-diene-3,20-dione

21-Acetyloxy-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Betamethasone Acetate (500 mg)

Betamethasone 21-ace

9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE

9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate

Dexamethasone Acetate Impurity 4（Dexamethasone Acetate EP Impurity D）

Betamethasone 21-Acetata

Betamethasone-4,6,11,12,12-d5 21-Acetate

BETAMETHASONE 21-ACETATE

BETAMETHASONE ACETATE

1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE

9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate

Betamethasone acetate BP/USP/EP

BETAMETHASONE ACETATE EPB(CRM STANDARD)

BETAMETHASONE ACETATE MM(CRM STANDARD)

BETAMETHASONE ACETATE USP(CRM STANDARD)

Betamethasone21-acetatemicro

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11.beta.,16.beta.)-

BETAMETHASONEACETATE,MICRONIZED,USP

9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 21-Acetate

Betamethasone acetate CRS

Betamethasone acetate Solution in Acetonitrile, 100μg/mL

Betamethasone 21-acetate USP/EP/BP

Betamethasone 21-Acetate D3Q: What is Betamethasone 21-Acetate D3 Q: What is the CAS Number of Betamethasone 21-Acetate D3 Q: What is the storage condition of Betamethasone 21-Acetate D3 Q: What are the applications of Betamethasone 21-Acetate D3

Betamethasone Acetate-d4Q: What is Betamethasone Acetate-d4 Q: What is the CAS Number of Betamethasone Acetate-d4

Betamethasone acetateQ: What is Betamethasone acetate Q: What is the CAS Number of Betamethasone acetate Q: What is the storage condition of Betamethasone acetate

Betamethasone Acetate API

Betamethasone Acetate (1067001)

2-((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Betamethasone Acetate Corticosteroid Raw Powder

Betamethasone 21-acetate/Betamethasone Acetate

1, 4-PREGNADIEN-9α-FLUORO-16β-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-ACETATE

Dexamethasone Acetate EP Impurity D (Betamethasone acetate)

BETAMETHASONE ACETATE | BETAMETHASONE 21-ACETATE

C10575005 BetamethasonEacetate

Dexamethasone Acetate Impurity D

987-24-6

4345

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