Trichloroacetyl isocyanate
- Product Name
- Trichloroacetyl isocyanate
- CAS No.
- 3019-71-4
- Chemical Name
- Trichloroacetyl isocyanate
- Synonyms
- 2,2,2-TRICHLOROACETYL ISOCYANATE;trichloroethanecarbonyl isocyanate;Trichloroacetyl isocyate;trichloro-acetylisocyanat;TRICHLOROACETYL ISOCYANATE;Acetyl isocyanate, trichloro-;Trichloroacetyl isocyanate ,97%;Trichloroacetyl isocyanate, GC 97%;Acetyl isocyanate, 2,2,2-trichloro-;Isocyanic Acid Trichloroacetyl Ester
- CBNumber
- CB1337310
- Molecular Formula
- C3Cl3NO2
- Formula Weight
- 188.4
- MOL File
- 3019-71-4.mol
Trichloroacetyl isocyanate Property
- Melting point:
- 135-140 °C
- Boiling point:
- 80-85 °C/20 mmHg (lit.)
- Density
- 1.581 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.480(lit.)
- Flash point:
- 150 °F
- storage temp.
- 2-8°C
- solubility
- Miscible with dichloromethane, ether, terahydrofuran and protic solvents.
- form
- Liquid
- color
- Clear colorless to slightly yellow
- Water Solubility
- Decomposition
- Sensitive
- Moisture Sensitive
- BRN
- 971201
- Stability:
- Hygroscopic, Moisture Sensitive
- InChIKey
- GRNOZCCBOFGDCL-UHFFFAOYSA-N
- CAS DataBase Reference
- 3019-71-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Trichloroacetyl isocyanate(3019-71-4)
- EPA Substance Registry System
- Acetyl isocyanate, trichloro- (3019-71-4)
Safety
- Hazard Codes
- T
- Risk Statements
- 14-23/24-34-42-23/24/25-36/37/38
- Safety Statements
- 23-26-36/37/39-45-8-7/9
- RIDADR
- UN 2206 6.1/PG 3
- WGK Germany
- 3
- F
- 10-19
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29291090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 217328
- Product name
- Trichloroacetyl isocyanate
- Purity
- 96%
- Packaging
- 1g
- Price
- $56.6
- Updated
- 2024/03/01
- Product number
- 217328
- Product name
- Trichloroacetyl isocyanate
- Purity
- 96%
- Packaging
- 10g
- Price
- $137
- Updated
- 2024/03/01
- Product number
- T1047
- Product name
- Trichloroacetyl Isocyanate
- Purity
- >97.0%(N)
- Packaging
- 1g
- Price
- $53
- Updated
- 2024/03/01
- Product number
- T1047
- Product name
- Trichloroacetyl Isocyanate
- Purity
- >97.0%(N)
- Packaging
- 5g
- Price
- $159
- Updated
- 2024/03/01
- Product number
- L00226
- Product name
- Trichloroacetyl isocyanate
- Purity
- 97%
- Packaging
- 2g
- Price
- $34.65
- Updated
- 2024/03/01
Trichloroacetyl isocyanate Chemical Properties,Usage,Production
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Trichloroacetyl isocyanate was used in catalytic one-pot dehydrative glycosylation of 1-hydroxy carbohydrate. It was also used as a reagent for the conversion of alcohols to carbamates.
Application
Trichloroacetyl Isocyanate is used as an in situ derivatizing reagent for characterization of alcohols, glycols, phenols, and amines by nuclear magnetic resonance (NMR).It has been reported in the literature that it can be used for the preparation of cefuroxime axetil.
Preparation
Trichloroacetyl isocyanate can be obtained by reacting 2,2,2-trichloroacetamide with oxalyl chloride.
Procedure: A reaction mixture of 2,2,2-trichloroacetamide (100 g, 616 mmol, 1.0 eq) in (COCl)2 (725 g, 5.71 mol, 500 mL, 9.28 eq) was heated to 70°C for 24 hours. The reaction mixture was concentrated under vacuum. To the mixture was added 1,2,4-trichlorobenzene (500 mL) and (COCl)2 (116 g, 914 mmol, 80 mL, 1.48 eq). The reaction mixture was stirred at 100°C for 5 hours. Heat to 125°C for 15 hours. The mixture was then heated to 140°C for 5 hours. The reaction mixture was distilled under water pump (72°C-76°C fractions) to give trichloroacetyl isocyanate (60 g, 319 mmol, 52% yield) as a colorless oil.
General Description
Conformational stability and vibrational IR and Raman spectra of trichloroacetyl isocyanate has been investigated. Trichloroacetyl isocyanate is commonly employed as in situ derivatizing reagent for the 13C NMR studies of alcohols, phenols and amines. It undergoes 1,5-cycloaddition reaction with anhydro-2-deoxy-D-erythro- and -L-threo-pent-1-enitols and 1,5-anhydro-2-deoxy-D- and -L-arabino-hex-1-enitols to yield [2+2] and [4+2] cycloadducts.
Trichloroacetyl isocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
Trichloroacetyl isocyanate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
View Lastest Price from Trichloroacetyl isocyanate manufacturers
- Product
- Trichloroacetyl isocyanate 3019-71-4
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-08
- Product
- Trichloroacetyl isocyanate 3019-71-4
- Price
- US $2759.64/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 500KG
- Release date
- 2021-03-24
- Product
- Trichloroacetyl isocyanate 3019-71-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-27