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Trimethyloxonium Tetrafluoroborate

Product Name
Trimethyloxonium Tetrafluoroborate
CAS No.
420-37-1
Chemical Name
Trimethyloxonium Tetrafluoroborate
Synonyms
TriMethyloxoniuM Fluoroborate;triMethyloxoiuM tetrafluoroborate;trimethyl-oxoniu tetrafluoroborate;SKL1456;SKL1563;NSC 528455;oxonium tetrafL;trimethyloxidanium;Oxonium, trimethyl-;Trimethoxonium fluoroborate
CBNumber
CB3184284
Molecular Formula
C3H9BF4O
Formula Weight
147.91
MOL File
420-37-1.mol
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Trimethyloxonium Tetrafluoroborate Property

Melting point:
200 °C
storage temp. 
Store at +2°C to +8°C.
solubility 
Soluble in nitrobenzene, nitromethane, chloroform, hot acetone, liquid sulfur dioxide. Slightly soluble in dichloromethane. Insoluble in common organic solvents.
form 
Crystals
color 
White to off-white
Sensitive 
Moisture Sensitive
BRN 
3597303
InChI
InChI=1S/C3H9O.BF4/c1-4(2)3;2-1(3,4)5/h1-3H3;/q+1;-1
InChIKey
JDFKFXJJAIJXPP-UHFFFAOYSA-M
SMILES
[B-](F)(F)(F)F.[O+](C)(C)C
CAS DataBase Reference
420-37-1(CAS DataBase Reference)
EPA Substance Registry System
Oxonium, trimethyl-, tetrafluoroborate(1-) (420-37-1)
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Safety

Hazard Codes 
C
Risk Statements 
14-34
Safety Statements 
26-36/37/39-43-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
3-10-21
Hazard Note 
Corrosive/Freeze
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29420000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
281077
Product name
Trimethyloxonium tetrafluoroborate
Purity
95%
Packaging
1g
Price
$39.6
Updated
2024/03/01
Sigma-Aldrich
Product number
281077
Product name
Trimethyloxonium tetrafluoroborate
Purity
95%
Packaging
10g
Price
$82.7
Updated
2024/03/01
TCI Chemical
Product number
T1507
Product name
Trimethyloxonium Tetrafluoroborate
Purity
>95.0%(T)
Packaging
5g
Price
$37
Updated
2024/03/01
TCI Chemical
Product number
T1507
Product name
Trimethyloxonium Tetrafluoroborate
Purity
>95.0%(T)
Packaging
25g
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
A15175
Product name
Trimethyloxonium tetrafluoroborate
Purity
96%
Packaging
10g
Price
$75
Updated
2024/03/01
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Trimethyloxonium Tetrafluoroborate Chemical Properties,Usage,Production

Description

Trimethyloxonium tetrafluoroborate (TMO), a trialkyloxonium salt, is a white salt at ambient temperature that can be added directly to reaction media to carry out the methylation of reactive, acidic analytes. The main drawback associated with the employment of TMO is the generation of tetrafluoroboric acid (HBF4), which may interfere with the analysis of acid-sensitive analytes and cause column degradation over time. However, the effects of this acid can be countered by neutralization with inorganic bases like sodium or potassium bicarbonate during the sample preparation step before instrument injection. This approach has proven crucially useful in analysing phosphonic and sulfonic acids related to organophosphorus-based nerve agents. TMO could be employed as a derivatizing agent in the methylation of a panel of environmentally relevant chlorinated phenols. It is also used in neutral and basic solutions for the selective methylation of the carboxyl groups of protohemin IX, hematohemin, and heme a[1-2].

Chemical Properties

This substance is a white to off-white crystals that is prone to water sensitivity and displays a level of hygroscopicity.

Uses

Trimethyloxonium Tetrafluoroborate is a trialkylated oxonium used as a methylation agent in organic synthesis. It is a reagent for the methylation of hydroxyl groups recently used in a complex, multistep synthesis directed towards spirastrellolide, a marine natural product.

Uses

Trimethyloxonium tetrafluoroborate act as a avmethylating agent and activates C-X multiple bonds. It is involved in the esterification of polyfunctional carboxylic acids. It acts as a catalyst in the polymerization of cyclic sulfides and ethers. Further, it is used in Beckmann rearrangement of oximes.

Health Hazard

Trimethyloxonium Tetrafluoroborate is a potent alkylating agent, with its non-volatile nature reducing associated hazards. Nevertheless, it produces strong acids upon contact with water, so it is important to exercise caution and prevent water contact during its application.

References

[1] Carlos A Valdez, Roald N Leif, Edmund P Salazar. “Trimethyloxonium-mediated methylation strategies for the rapid and simultaneous analysis of chlorinated phenols in various soils by electron impact gas chromatography-mass spectrometry.” Scientific Reports (2022): 1401.
[2] R T Dean, D E Hultquist, L J DeFilippi. “Esterification of hemins with trimethyloxonium tetrafluoroborate.” Analytical biochemistry 76 l (1976): 1–8.

Trimethyloxonium Tetrafluoroborate Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethyloxonium Tetrafluoroborate Suppliers

Wuxi InterpiPharm, Inc.
Tel
0510-83782303 13771177691
Fax
0510- 8378-9906
Email
sales@itppharm.com
Country
China
ProdList
110
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62
Shanghai Mixiu Chemical Co., Ltd.
Tel
18101936766
Fax
021-58583907
Email
eileen@shmychem.com
Country
China
ProdList
350
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55
Doly Chemical CO.,LTD.
Tel
021-34716221 15800796336
Fax
+86-21-31329566
Email
sales@dolypharm.com
Country
China
ProdList
294
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55
Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999 18232719690
Fax
0536-7971999
Email
sgjiasheng@hotmail.com
Country
China
ProdList
353
Advantage
58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1687
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58
Rushpharm Co.,Ltd.
Tel
025-66042949 15161141411
Fax
025-66042949
Email
2244332520@qq.com
Country
China
ProdList
55
Advantage
58
Foshan Yuhang New Materials Co., Ltd
Tel
0757-18928797409 13078814179
Email
1670287326@qq.com
Country
China
ProdList
982
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
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View Lastest Price from Trimethyloxonium Tetrafluoroborate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
Trimethyloxonium Tetrafluoroborate 420-37-1
Price
US $0.00-0.00/KG
Min. Order
100KG
Purity
99.9%
Supply Ability
20TONS
Release date
2023-10-10
Anhui Ruihan Technology Co., Ltd
Product
Trimethyloxonium Tetrafluoroborate 420-37-1
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11
LY Global chemicals co.,ltd .
Product
TRIMETHYLOXONIUM TETRAFLUOROBORATE 420-37-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% Min
Supply Ability
1000kg
Release date
2023-03-18

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