Trimethyloxonium Tetrafluoroborate
- Product Name
- Trimethyloxonium Tetrafluoroborate
- CAS No.
- 420-37-1
- Chemical Name
- Trimethyloxonium Tetrafluoroborate
- Synonyms
- TriMethyloxoniuM Fluoroborate;triMethyloxoiuM tetrafluoroborate;trimethyl-oxoniu tetrafluoroborate;SKL1456;SKL1563;Me3OBF4;NSC 528455;oxonium tetrafL;trimethyloxidanium;Oxonium, trimethyl-
- CBNumber
- CB3184284
- Molecular Formula
- C3H9BF4O
- Formula Weight
- 147.91
- MOL File
- 420-37-1.mol
Trimethyloxonium Tetrafluoroborate Property
- Melting point:
- 200 °C
- storage temp.
- Store at +2°C to +8°C.
- solubility
- Soluble in nitrobenzene, nitromethane, chloroform, hot acetone, liquid sulfur dioxide. Slightly soluble in dichloromethane. Insoluble in common organic solvents.
- form
- Crystals
- color
- White to off-white
- Sensitive
- Moisture Sensitive
- BRN
- 3597303
- InChI
- InChI=1S/C3H9O.BF4/c1-4(2)3;2-1(3,4)5/h1-3H3;/q+1;-1
- InChIKey
- JDFKFXJJAIJXPP-UHFFFAOYSA-M
- SMILES
- [B-](F)(F)(F)F.[O+](C)(C)C
- CAS DataBase Reference
- 420-37-1(CAS DataBase Reference)
- EPA Substance Registry System
- Oxonium, trimethyl-, tetrafluoroborate(1-) (420-37-1)
Safety
- Hazard Codes
- C
- Risk Statements
- 14-34
- Safety Statements
- 26-36/37/39-43-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 3-10-21
- Hazard Note
- Corrosive/Freeze
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29420000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 281077
- Product name
- Trimethyloxonium tetrafluoroborate
- Purity
- 95%
- Packaging
- 1g
- Price
- $40.8
- Updated
- 2025/07/31
- Product number
- 281077
- Product name
- Trimethyloxonium tetrafluoroborate
- Purity
- 95%
- Packaging
- 10g
- Price
- $85.2
- Updated
- 2025/07/31
- Product number
- T1507
- Product name
- Trimethyloxonium Tetrafluoroborate
- Purity
- >95.0%(T)
- Packaging
- 5g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- T1507
- Product name
- Trimethyloxonium Tetrafluoroborate
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- 08-2500
- Product name
- Trimethyloxonium tetrafluoroborate, min. 95%
- Packaging
- 5g
- Price
- $76
- Updated
- 2024/03/01
Trimethyloxonium Tetrafluoroborate Chemical Properties,Usage,Production
Description
Trimethyloxonium tetrafluoroborate (TMO), a trialkyloxonium salt, is a white salt at ambient temperature that can be added directly to reaction media to carry out the methylation of reactive, acidic analytes. The main drawback associated with the employment of TMO is the generation of tetrafluoroboric acid (HBF4), which may interfere with the analysis of acid-sensitive analytes and cause column degradation over time. However, the effects of this acid can be countered by neutralization with inorganic bases like sodium or potassium bicarbonate during the sample preparation step before instrument injection. This approach has proven crucially useful in analysing phosphonic and sulfonic acids related to organophosphorus-based nerve agents. TMO could be employed as a derivatizing agent in the methylation of a panel of environmentally relevant chlorinated phenols. It is also used in neutral and basic solutions for the selective methylation of the carboxyl groups of protohemin IX, hematohemin, and heme a[1-2].
Chemical Properties
This substance is a white to off-white crystals that is prone to water sensitivity and displays a level of hygroscopicity.
Uses
Trimethyloxonium Tetrafluoroborate is a trialkylated oxonium used as a methylation agent in organic synthesis. It is a reagent for the methylation of hydroxyl groups recently used in a complex, multistep synthesis directed towards spirastrellolide, a marine natural product.
Uses
Trimethyloxonium tetrafluoroborate act as a avmethylating agent and activates C-X multiple bonds. It is involved in the esterification of polyfunctional carboxylic acids. It acts as a catalyst in the polymerization of cyclic sulfides and ethers. Further, it is used in Beckmann rearrangement of oximes.
Health Hazard
Trimethyloxonium Tetrafluoroborate is a potent alkylating agent, with its non-volatile nature reducing associated hazards. Nevertheless, it produces strong acids upon contact with water, so it is important to exercise caution and prevent water contact during its application.
Synthesis
115-10-6
109-63-7
420-37-1
The general procedure for the preparation of trimethoxonium tetrafluoroborate is as follows (adapted with minor modifications from TJ. Curphey, Org. Synth., Coll. vol. 6, p. 1019 (1988)): 1. add 80 mL of dichloromethane (DCM) to a 500 mL three-necked round-bottomed flask (equipped with an N2 inlet, 60 mL pressure-equalizing dropping funnel, magnetic stirring bar, and rubber septum, and marked at approximately 190 mL) that has been pre-dried in an oven, under the protection of dry nitrogen gas. 2. 33.3 mL (270 mmol) of boron trifluoride ether compound was added, followed by cooling the mixture in a dry ice-acetone bath. 3. condense the DME into the DCM solution through a needle inserted through the rubber septum, which should remain just below the liquid level until the total volume of liquid reaches the 190mL mark. 4. add 24.1mL (307mmol) of epichlorohydrin dropwise over approximately 15 minutes with vigorous stirring (note: the mixture will become very viscous and may need to be rotated manually to ensure adequate stirring). 5. Remove the cooling bath and continue to vigorously stir the mixture overnight at room temperature. 6. Upon completion of the reaction, the resulting solid product was collected by filtration through a medium glass-filled Brinell's funnel, which had been pre oven-dried, under a stream of N2 gas. 7. The flask and filter were rinsed with dichloromethane (2 x 100mL) to remove the solids. 8. After drying under nitrogen protection, 29.4 g (98% yield) of free flowing white solid trimethoxonium tetrafluoroborate was obtained. 9. Store the product in a pre-oven dried glass vial in a nitrogen protected refrigerator.
References
[1] Carlos A Valdez, Roald N Leif, Edmund P Salazar. “Trimethyloxonium-mediated methylation strategies for the rapid and simultaneous analysis of chlorinated phenols in various soils by electron impact gas chromatography-mass spectrometry.” Scientific Reports (2022): 1401.
[2] R T Dean, D E Hultquist, L J DeFilippi. “Esterification of hemins with trimethyloxonium tetrafluoroborate.” Analytical biochemistry 76 l (1976): 1–8.
Trimethyloxonium Tetrafluoroborate Preparation Products And Raw materials
Raw materials
Preparation Products
Trimethyloxonium Tetrafluoroborate Suppliers
- Tel
- 400-106-2016 17800804092
- admin@infsci.com
- Country
- China
- ProdList
- 553
- Advantage
- 55
- Tel
- 510-83782303 13771177691
- Fax
- 0510- 8378-9906
- sales@itppharm.com
- Country
- China
- ProdList
- 110
- Advantage
- 62
- Tel
- 18101936766
- Fax
- 021-58583907
- eileen@shmychem.com
- Country
- China
- ProdList
- 350
- Advantage
- 55
- Tel
- 021-34716221 15800796336
- Fax
- +86-21-31329566
- sales@dolypharm.com
- Country
- China
- ProdList
- 289
- Advantage
- 55
- Tel
- 0536-7971999 13583611556
- Fax
- 0536-7971999
- sgjiasheng@hotmail.com
- Country
- China
- ProdList
- 300
- Advantage
- 58
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 025-66042949 15161141411
- Fax
- 025-66042949
- 2244332520@qq.com
- Country
- China
- ProdList
- 55
- Advantage
- 58
- Tel
- 15860871137
- Z15860871137@qq.com
- Country
- China
- ProdList
- 75
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2802
- Advantage
- 65
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 0371-56669001 13949088811
- Fax
- 0371-56669008
- Sales@58chem.cn
- Country
- China
- ProdList
- 89
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 3997
- Advantage
- 55
- Tel
- 027-8866 0053/88660577/88660578
- Fax
- 027-8899 1911
- Country
- China
- ProdList
- 1073
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 0086-571-86217390
- Fax
- 0086-571-86217391
- Sales@gihichem.com
- Country
- China
- ProdList
- 860
- Advantage
- 58
- Tel
- 010-57495520 13521095525
- zhw512@foxmail.com
- Country
- China
- ProdList
- 488
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0371-0371-13526885213 15637198702
- Fax
- 0371-63709726
- hsyykjchem@163.com
- Country
- China
- ProdList
- 3852
- Advantage
- 58
View Lastest Price from Trimethyloxonium Tetrafluoroborate manufacturers
- Product
- TRIMETHYLOXONIUM TETRAFLUOROBORATE 420-37-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2025-04-24
- Product
- Trimethyloxonium Tetrafluoroborate 420-37-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-04-12
- Product
- Trimethyloxonium Tetrafluoroborate 420-37-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 100KG
- Purity
- 99.9%
- Supply Ability
- 20TONS
- Release date
- 2023-10-10