ChemicalBook > CAS DataBase List > 4-Bromo-2,6-difluorobenzaldehyde

4-Bromo-2,6-difluorobenzaldehyde

Product Name: 4-Bromo-2,6-difluorobenzaldehyde
CAS No.: 537013-51-7
Chemical Name: 4-Bromo-2,6-difluorobenzaldehyde
Synonyms: 4-BROMO-2,6-DIFLUOROBENZALDEHYDE;CAS:537013-51-7;2,6-Difluoro-4-bromo benzaldehyde;4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE;Benzaldehyde, 4-broMo-2,6-difluoro-;4-Bromo-2,6-difluorobenzaldehyde >4-Bromo-2,6-difluorobenzaldehyde 96%;4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE ISO 9001：2015 REACH
CBNumber: CB1338438
Molecular Formula: C7H3BrF2O
Formula Weight: 221
MOL File: 537013-51-7.mol

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4-Bromo-2,6-difluorobenzaldehyde Property

Melting point:: 76-81 °C
Boiling point:: 231.4±40.0℃ (760 Torr)
Density: 1.758±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 93.7±27.3℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
color: White to Light yellow to Light orange
Sensitive: Air Sensitive
InChI: InChI=1S/C7H3BrF2O/c8-4-1-6(9)5(3-11)7(10)2-4/h1-3H
InChIKey: CZGVAISJIQNQEJ-UHFFFAOYSA-N
SMILES: C(=O)C1=C(F)C=C(Br)C=C1F
CAS DataBase Reference: 537013-51-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706957
Product name: 4-Bromo-2,6-difluorobenzaldehyde
Purity: 96%
Packaging: 5g
Price: $171
Updated: 2025/07/31

TCI Chemical

Product number: B3446
Product name: 4-Bromo-2,6-difluorobenzaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: B3446
Product name: 4-Bromo-2,6-difluorobenzaldehyde
Purity: >98.0%(GC)
Packaging: 100mg
Price: $16
Updated: 2025/07/31

TRC

Product number: B700345
Product name: 4-Bromo-2,6-difluorobenzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB34001
Product name: 4-Bromo-2,6-difluorobenzaldehyde
Packaging: 25g
Price: $175
Updated: 2021/12/16

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4-Bromo-2,6-difluorobenzaldehyde Chemical Properties,Usage,Production

Uses

4-Bromo-2,6-difluorobenzaldehyde can be used as organic synthesis and pharmaceutical intermediates, mainly in laboratory research and development, chemical and pharmaceutical production processes.

Synthesis

n-Butyl lithium (0.64ml, 1.2 mmol) was added drop wise to a solution of diisopropyl amine (0.25 mL, 1.5 mmol) in dry THF at -78°C under nitrogen atmosphere over a period of 5 minutes. The reaction mixture was stirred at -20°C for 30 minutes. To this was added 5-bromo-benzo[b]thiophene (200 mg, 0.938 mmol) in dry THF at -78°C, continued stirring for a further 30 minutes at -78°C, followed by the addition of N-chlorosuccinamide (225 mg, 1.68 mmol) in dry THF at -78°C. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% hexane). The reaction mixture was partitioned between ethyl acetate and saturated ammonium chloride. The organic layer was dried over sodium sulfate and concentrated to afford the crude product. Purification by column chromatography on silica gel (100% hexane) afforded the product. Preparation of Intermediate 4-Bromo-2,6-difluoro-benzaldehyde (I-26a): Using analogous reaction condition and reagents as described in Example 20 for the preparation of 1-20a above, 1-bromo-3,5-difluoro-benzene (2 g, 2.10.36 mmol) in THF was reacted with DMF (1.43 g,19.68 mmol), n-butyl lithium (1.56 ml, 12.4 mmol) and diisopropyl amine (0.57 mL, 15.5 mmol) to afford crude product. Purification by column chromatography on silica gel (2% ethyl acetate in hexane) afforded 1.35 g of the product (61% yield). 1H NMR (CDCl3, 300 MHz): δ 11.5-11.0 (s, 1H), 7.4-7.2 (dd, 2H).

References

[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 4, p. 818 - 826
[2] Patent: WO2007/49123, 2007, A1. Location in patent: Page/Page column 69-70
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 23, p. 7100 - 7105
[4] Patent: US2015/57309, 2015, A1. Location in patent: Paragraph 0569
[5] Patent: WO2016/11390, 2016, A1. Location in patent: Page/Page column 268; 269

4-Bromo-2,6-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-2,6-difluorobenzaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-2,6-difluorobenzaldehyde 537013-51-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-04

Qingdao RENAS Polymer Material Co., Ltd.

Product: 4-bromo-2,6-difluorobenzaldehyde 537013-51-7
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-04-01

Hangzhou ICH Biofarm Co., Ltd

Product: 4-Bromo-2,6-difluorobenzaldehyde 537013-51-7
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

537013-51-7, 4-Bromo-2,6-difluorobenzaldehydeRelated Search:

2-Bromofluorobenzene 4-Bromo-2,6-difluorobenzoic acid RARECHEM AL BI 1306 4-BROMO-2,3,6-TRIFLUOROBENZALDEHYDE 4-Bromo-2,6-difluorobenzaldehyde TERT-BUTYL 4-BROMO-2,6-DIFLUOROBENZOATE TERT-BUTYL 4-BROMO-2,3,5,6-TETRAFLUOROBENZOATE 2,6-Difluorobenzaldehyde 4-BROMO-2,6-DIFLUOROBENZOYL CHLORIDE 4-BROMO-2,3,5,6-TETRAFLUOROBENZOIC ACID RARECHEM AL BF 1308 RARECHEM AL BI 1308 Methyl 4-bromo-2,6-difluorobenzoate RARECHEM AL BE 1308 4-BROMO-2,3,5,6-TETRAFLUOROBENZOYL CHLORIDE

4-BROMO-2,6-DIFLUOROBENZALDEHYDE

4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE

2,6-Difluoro-4-bromo benzaldehyde

Benzaldehyde, 4-broMo-2,6-difluoro-

4-Bromo-2,6-difluorobenzaldehyde 96%

4-Bromo-2,6-difluorobenzaldehyde &gt

4-BROMO-2,6-DIFLUOROBENZYLALDEHYDE ISO 9001：2015 REACH

CAS:537013-51-7

537013-51-7

530713-51-7

207739-84-4

Benzaldehyde