2,6-Difluorobenzaldehyde
- Product Name
- 2,6-Difluorobenzaldehyde
- CAS No.
- 437-81-0
- Chemical Name
- 2,6-Difluorobenzaldehyde
- Synonyms
- TIMTEC-BB SBB006685;2,6-Difluorobenzalde;2-6-Difluorbenzaldehyd;2,6-fluorobenzaldehyde;2,6-DIFLUOROBENZALDEHYDE;2,6-difluorobenzaledehyde;2,6-DIFLUORLOBENZALDEHYDE;2,12-Difluoroacetophenone;2,6-Difluorobenzaldehyde98%;2,6-Difluorobenzaldehyde>
- CBNumber
- CB3126149
- Molecular Formula
- C7H4F2O
- Formula Weight
- 142.1
- MOL File
- 437-81-0.mol
2,6-Difluorobenzaldehyde Property
- Melting point:
- 15-17 °C (lit.)
- Boiling point:
- 82-84 °C/15 mmHg (lit.)
- Density
- 1.317 g/mL at 25 °C (lit.)
- vapor pressure
- 40.1-900hPa at 94.5-189℃
- refractive index
- n20/D 1.502(lit.)
- Flash point:
- 164 °F
- storage temp.
- 2-8°C
- form
- Liquid
- Specific Gravity
- 1.317
- color
- Clear light yellow to bright yellow
- Sensitive
- Air Sensitive
- BRN
- 1935273
- InChIKey
- SOWRUJSGHKNOKN-UHFFFAOYSA-N
- LogP
- 1.46 at 25℃ and pH2
- Surface tension
- 73.1mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 437-81-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39-36/37
- WGK Germany
- 2
- F
- 10-23
- HazardClass
- IRRITANT
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 265152
- Product name
- 2,6-Difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $27.5
- Updated
- 2025/07/31
- Product number
- 265152
- Product name
- 2,6-Difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $131
- Updated
- 2025/07/31
- Product number
- D2452
- Product name
- 2,6-Difluorobenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- D2452
- Product name
- 2,6-Difluorobenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $162
- Updated
- 2025/07/31
- Product number
- D451333
- Product name
- 2,6-Difluorobenzaldehyde
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
2,6-Difluorobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
clear light yellow to bright yellow liquid
Uses
2,6-Difluorobenzaldehyde can be used as a reactant to synthesize:
- 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil via one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea.
- 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole by reacting with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.
- (3E)-4-(2,6-Difluorophenyl)-3-buten-2-one by Wittig olefination reaction with acetylmethylidenetriphenyl phosphorane.
- Methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating with methyl thioglycolate in the presence of K2CO3.
Synthesis
83-38-5
437-81-0
The general procedure for the synthesis of 2,6-dichlorobenzaldehyde from 2,6-dichlorobenzaldehyde was as follows: first, 34.8 g (0.6 mol) of potassium fluoride (KF) was dissolved in 250 mL of cyclobutanesulfone under nitrogen protection and stirred at 100 °C for 2 h. The water was removed by azeotropic distillation. Subsequently, 20 g (0.11 mol) of 2,6-dichlorobenzaldehyde and 2.8 g (6.68 mmol) of tetraphenylphosphonium bromide were added to this anhydrous mixture and the reaction mixture was heated to 180 °C and kept overnight. Upon completion of the reaction, the solid product was washed with ethyl acetate and the solvent was removed by aqueous pressure evaporation. Finally, the target product 2,6-difluorobenzaldehyde was purified by vacuum evaporation (24 mbar, 85-86 °C) in 77% yield.
References
[1] Patent: WO2016/102207, 2016, A1. Location in patent: Page/Page column 32
[2] Journal of Fluorine Chemistry, 2004, vol. 125, # 6, p. 1031 - 1038
[3] Chemistry Letters, 1988, # 9, p. 1355 - 1358
[4] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2720 - 2725
[5] Patent: US6103659, 2000, A
2,6-Difluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Difluorobenzaldehyde manufacturers
- Product
- 2,6-Difluorobenzaldehyde 437-81-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 2,6-Difluorobenzaldehyde 437-81-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-20
- Product
- 2, 6-Difluoro-Benzaldehyde 437-81-0
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21