(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane

Product Name: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane
CAS No.: 144164-11-4
Chemical Name: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane
Synonyms: Thiazol-5-ylMethyl ((2S,3S,5S)-5-aMino-3-hydroxy-1,6-diphenylhexan-2-yl)carbaMate;RIT-X;RT-10;RitovirImpurity20;Ritonavir Impurity 1;Ritonavir Impurity 26;Ritonavir Intermediate 2;Falecalcitriol Impurity 28;amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate;(5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamic acid
CBNumber: CB1340950
Molecular Formula: C23H27N3O3S
Formula Weight: 425.54
MOL File: 144164-11-4.mol

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(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane Property

Boiling point:: 656.1±55.0 °C(Predicted)
Density: 1.251±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 11.48±0.46(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A630525
Product name: 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
Packaging: 50g
Price: $1110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17438
Product name: 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
Packaging: 50mg
Price: $1638
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0004595
Product name: (2S,3S,5S)-5-AMINO-2-(N-((5-THIAZOLYL)-METHOXYCARBONYL)AMINO)-1,6-DIPHENYL-3-HYDROXYHEXANE
Purity: 95.00%
Packaging: 1G
Price: $1963.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17438
Product name: 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
Packaging: 25mg
Price: $901
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17438
Product name: 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
Packaging: 5mg
Price: $272.6
Updated: 2021/12/16

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(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Oil

Uses

An intermediate in the synthesis of Ritonavir.

Synthesis

162849-95-8

144164-11-4

Example 4. Preparation of (2S,3S,5S)-5-amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane: (2S,3S,5S)-5-(tert-butoxycarbonylamino)-2-(N-5-thiazolylcarbonylmethoxycarbonyl)amino-1,6-diphenyl-3-hydroxyhexane (1.2g, 6.2 mmol) was dissolved in 4N HCl/dioxane solution (12 mL) and the reaction was stirred for 3 hours at room temperature. After completion of the reaction, the mixture was concentrated under vacuum and the residue was ground with EtOAc and filtered to give a white solid product (0.93 g, 98.2% yield). The product was characterized by 1H NMR (300MHz, DMSO-D6): δ 1.58 (t, J = 6.3Hz, 2H), 2.54-2.68 (m, 1H), 2.72-2.93 (m, 3H), 3.41-3.55 (m, 1H), 5.13 (s, 2H), 7.04-7.47 (m, 11H), 7.84 (s, 1H), 9.07 (s, 1H). 1H), 9.07 (s, 1H); MS (ESI) m/z 426.1 (M + H)+.

References

[1] Patent: WO2008/27932, 2008, A2. Location in patent: Page/Page column 96
[2] Patent: WO2006/90264, 2006, A1. Location in patent: Page/Page column 22-23
[3] Patent: WO2006/90270, 2006, A1. Location in patent: Page/Page column 11
[4] Patent: EP1170289, 2002, A2. Location in patent: Page 45
[5] Patent: WO2005/111006, 2005, A1. Location in patent: Page/Page column 17-18

(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane Suppliers

Canada 2 China 101 India 3 United Kingdom 1 United States 5 Global 112

J & K SCIENTIFIC LTD.

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View Lastest Price from (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane manufacturers

Henan Fengda Chemical Co., Ltd

Product: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane 144164-11-4
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Hangzhou ICH Biofarm Co., Ltd

Product: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane 144164-11-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-12-13

Career Henan Chemical Co

Product: (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane 144164-11-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 50kg
Release date: 2019-06-26

144164-11-4, (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexaneRelated Search:

Methylcyclohexane 6-Aminocaproic acid Cyclohexane ALTRENOGEST 3,4'-DIAMINODIPHENYLMETHANE Hexane Biphenyl Tris(hydroxymethyl)aminomethane Glycine Des(isopropylthiazolyl) Hydantoin Ritonavir Ritonavir EP Impurity B (5S,8S,9S,11S)-9-Hydr Ritonavir EP Impurity O (4S,5S)-4-Benzyl-5-[(2S)-2-((4S)-4-isopropyl-2,5-dioxoiMidazolidin-1-yl)-3-phenylpropyl]-2-oxo-1,3-oxazolidine-3-carboxylate thiazol-5-ylMethyl Ester Ritonavir EP Impurity I Ritonavir EP Impurity C Thiazol-5-ylmethyl-[(1S,2S,4S)-1-benzyl-4-[[(2S)-2-[[[[2-(1-hydroperoxy-1-methylethyl)thiazol-4-yl]m Ritonavir Impurity 5

2S,3S,5S-5-AMINO-2-[N-[[(5-THIAZOLYL)METHOXY]CARBONYL]AMINO]-1,6-DIPHENYL-3-HYDROXYHEXANE

RIT-X

Thiazol-5-ylMethyl ((2S,3S,5S)-5-aMino-3-hydroxy-1,6-diphenylhexan-2-yl)carbaMate

1,3-Thiazol-5-ylMethyl N-[(1S,2S,4S)-4-aMino-1-benzyl-2-hydroxy-5-phenylpentyl]car baMate

(5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamic acid

Carbamic acid,N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-,5-thiazolylmethyl ester

(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane###144164-11-4

Ritonavir Impurity 1

amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate

N-(5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamic acid 5-thiazolylmethyl ester

Ritonavir Intermediate 2

Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-

1,3-Thiazol-5-ylmethyl n-[(2s,3s,5s)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl]carbamate

Ritonavir Impurity 26

(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino...

RitovirImpurity20

Thiazol-5-ylmethyl [(1S,2S,4S)-4-Amino-1-benzyl-2-hydroxy-5-phenylpentyl]carbamate

thiazol-5-ylmethyl (5-amino-1,6-diphenylhexan-2-yl)carbamate

Falecalcitriol Impurity 28

(2S,3S,5S)-5-Amino-2-(N-((5-Thiazolyl)-Methoxycarbonyl)Amino)-3-Hydroxy-1,6-Diphenylhexane

RT-10

144164-11-4

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Heterocycles

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