Description Application Mechanism of action
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Citicoline sodium

Description Application Mechanism of action
Product Name
Citicoline sodium
CAS No.
33818-15-4
Chemical Name
Citicoline sodium
Synonyms
CITICOLINE;CITICOLINE SODIUM SALT;CITICOLINE MONOSODIUM SALT;GDPC;Logan;Brassel;Cidifos;Gerolin;Sinkron;Cebroton
CBNumber
CB1343597
Molecular Formula
C14H26N4O11P2.Na
Formula Weight
511.31
MOL File
33818-15-4.mol
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Citicoline sodium Property

Melting point:
259-268°C (dec.)
alpha 
D20 +12.5° (c = 1.0 in H2O)
storage temp. 
-20°C
solubility 
H2O: 100mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (100 mg/ml).
λmax
280nm(HCl aq.)(lit.)
Merck 
13,2343
BRN 
4110040
InChIKey
YWAFNFGRBBBSPD-OCMLZEEQSA-M
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,21,r|
CAS DataBase Reference
33818-15-4
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
3-10-21
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34015
Product name
Citicoline sodium salt hydrate
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
30290
Product name
Cytidine 5′-diphosphocholine sodium salt hydrate
Purity
≥99.0% (HPLC)
Packaging
250mg
Price
$250
Updated
2024/03/01
Sigma-Aldrich
Product number
30290
Product name
Cytidine 5′-diphosphocholine sodium salt hydrate
Purity
≥99.0% (HPLC)
Packaging
1g
Price
$550
Updated
2024/03/01
TCI Chemical
Product number
C3445
Product name
Cytidine 5'-Diphosphocholine Sodium Salt
Purity
>98.0%(HPLC)
Packaging
1g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
C3445
Product name
Cytidine 5'-Diphosphocholine Sodium Salt
Purity
>98.0%(HPLC)
Packaging
5g
Price
$57
Updated
2024/03/01
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Citicoline sodium Chemical Properties,Usage,Production

Description

Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.

Application

  • Central nervous system medication.
  • Coenzyme. For acute traumatic brain injury and brain surgery consciousness. Acute brain injury and brain surgery after a disturbance of consciousness, paralysis due to stroke can gradually restore the function of the limbs, it can also be used for functions and other central nervous system disorders of consciousness caused by acute injury, and also for ischemic cerebrovascular disease and vascular dementia.

Mechanism of action

Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory.

Chemical Properties

White Solid

Uses

Cytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Uses

Cytidine-5'-diphosphocholine sodium salt hydrate acts as a neuroprotective agent in situations of hypoxia and ischemia. It is used as biosynthetic intermediate of membrane phospholipids. It is a cerebral vasodilator and inhibits PLA2 activation.

Uses

Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.

Application

Citicoline (CDP-choline) is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine (PtdCho). It increases plasma adrenocorticotropic hormone (ACTH) levels and potentiates serum thyrotrophin (TSH) levels by activating the central cholinergic system.
Citicoline Sodium is used to treat age-related memory loss, cerebrovascular diseases such as stroke, dementia, as well as head trauma. Research has shown that it increases a chemical called phosphatidylcholine which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. Citicoline Sodium is also said to help with weight management when used as a dietary supplement.

brand name

CerAxon (Interneuron).

General Description

Cytidine 5′-diphosphocholine (CDP-choline) contains cytidine and choline linked via a diphosphate bridge.

Biochem/physiol Actions

Cytidine 5′-diphosphocholine (CDP-choline) plays an important role in the synthesis of phosphatidylcholine. It is also involved in the biosynthesis of acetylcholine, a neurotransmitter. CDP-choline has therapeutic effects against hypoxia, cerebral ischemia and traumatic brain injury. It also exhibits therapeutic effects against learning and memory disorders, drug addiction and Alzheimer′s and Parkinson′s diseases.

Side effects

Citicoline sodium may be safe for 12 weeks of oral use, side effects may include stomach pain, back pain, blurred vision, constipation and headache. While Citicoline 2% Eye Drops may be safe for long-term use (up to 3 years). No serious side effects have been reported by clinical investigators in the treatment of Parkinson's disease.

Safety

There are two forms of citicoline: citicoline sodium and citicoline free-base. Citicoline sodium is the form that is approved as a prescription medication in some European countries and throughout Asia. Citicoline free-base is the form that is available as a dietary supplement and food/beverage ingredient in the United States. In Europe, citicoline is approved as a Novel Food ingredient and is authorized to be used in food supplements up to 500 mg per day. It is also authorized to be used for Food for Special Medical Purposes (FSMPs) in amounts of 250 mg/serving and up to 1,000 mg per day.
Citicoline free-base is produced in Japan by Kyowa Hakko Bio Co. Ltd. under the brand name of Cognizin. Cognizin is considered to be safe and received self-designated Generally Recognized As Safe (GRAS) status in 2009. In Europe, citicoline was approved as a Novel Food ingredient in 2014. Whereas most companies produce citicoline synthetically, Cognizin is produced using a patented, natural fermentation process. It is vegetarian and allergen-free. Kyowa Hakko manufactures and supplies Cognizin as a raw ingredient to many manufacturers around the world.

Metabolism

Citicoline can be administered orally, intramuscularly, or intravenously. Oral administration is most common because its bioavailability is approximately 92%. After oral ingestion, citicoline is hydrolyzed in the small intestine and liver into 2 major metabolites: cytidine and choline.
Cytidine and choline enter the systemic circulation, where cytidine is further metabolized into uridine. Both uridine and free choline cross the blood-brain barrier. In the central nervous system, uridine is converted to cytidine triphosphate, choline is converted to phosphocholine, and the 2 combine to resynthesize CDP-choline.

Citicoline sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Citicoline sodium Suppliers

Americas 1 Canada 1 China 448 China Hong Kong 1 Europe 3 Germany 6 India 36 Italy 2 Japan 3 Singapore 1 South Korea 1 Switzerland 1 United Kingdom 9 United States 34 Global 547
HBCChem, Inc.
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ALB Technology Limited
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BOC Sciences
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16314854226
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info@bocsci.com
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9923
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BOC Sciences
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16314854226; +16314854226
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inquiry@bocsci.com
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19741
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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Cato Research Chemicals Inc.
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020-81215950 4000-868-328
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customer@uwalab.com
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Protheragen-ING
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Aladdin Scientific
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HBCChem Inc.
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AlliChem, LLC
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Cayman Chemical Company
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United States Biological
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MedChemExpress
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Combi-Blocks Inc.
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Riedel-de Haen AG
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TCI America
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Frontier Scientific, Inc.
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Synthland Hong Kong Limited
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Oakwood Products, Inc.
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AstaTech, Inc
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Sciencelab.com, Inc.
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HONEST JOY HOLDINGS LIMITED
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Advance Scientific & Chemical
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Aceto Corporation
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BIOMOL INTERNATIONAL, LP
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Beta Pharma, Inc.
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MP Biomedicals, Inc.
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View Lastest Price from Citicoline sodium manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Citicoline sodium 33818-15-4
Price
US $90.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-06-07
Watson Biotechnology Co.,Ltd
Product
Citicoline sodium 33818-15-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-09-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Citicoline sodium 33818-15-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1000kg/month
Release date
2021-07-31

33818-15-4, Citicoline sodiumRelated Search:

Sodium chlorite CYTIDINE 5'-DIPHOSPHOCHOLINE Sodium citrate Sodium chloride Sodium benzoate Sodium acetate Sodium hydroxide Tris(trimethylsilyl)phosphate Cytosine Ethyl acrylate SULPHOSUCCINIC ACID ESTER Citiolone Sodium bicarbonate Diclofenac sodium Cytidine Ethyl acetate Trisodium phosphate Ethylparaben

  • P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM
  • cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt
  • CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT
  • CYTIDINE-5'-DIPHOSPHOCHOLINE, NA
  • CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM
  • CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT
  • CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE
  • CITICOLINE SODIUM SALT
  • CITICOLINE
  • CITICOLINE MONOSODIUM SALT
  • CITICOLINE SODIUM
  • CDP-CHOLINE MONOSODIUM SALT
  • CDP-CHOLINE, NA
  • CDP-CHOLINE, SODIUM SALT
  • CDP-COLINE
  • Cytidine 5'-(trihydrogen diphosphate), mono[2-(trimethylammonio)ethyl] ester, hydroxide, inner salt, monosodium salt
  • Citicoline Sodium, Vetranal
  • Cdp-Choline(CytidineDiphosphateCholine)
  • cytidin-5'-diphosphocholin sodium salt hydrate
  • CDP-CHOLINE, SODIUM
  • Cytidine 5'-Diphosphocholine Sodium Salt CDP-choline.Na
  • CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE 99.0%
  • Cytidine5'-(trihydrogen diphosphate), P'-[2-(triMethylaMMonio)ethyl] ester, inner salt,sodiuM salt (1:1)
  • Citicoline sod
  • Cytidine 5′-diphosphocholine sodium salt hydrate
  • CDP-coline Citicoline sodium
  • cytidine 5′-(tri-hydro-gen di-phos-phate) inner salt monosodium
  • P′-[2-(Trimethylammonio)-ethyl]-ester
  • Cytidoline sodium salt
  • Cytidine 5'-diphosphocholine, Sodium Salt (CDP-choline)
  • Citicoline Sodium Salt (CDP-Choline)
  • 5′-Diphosphocholine Sodium Salt
  • GDPC
  • CDP-choline-Na, CDP-coline, Citicoline sodium, Cytidine 5μ-diphosphocholine dihydrate sodium salt, Pμ-[2-(Trimethylammonio)ethyl]ester cytidine 5μ-(trihydrogen diphosphate) inner salt monosodium
  • CDP-choline-Na, CDP-coline, Citicoline sodium, Pμ-[2-(Trimethylammonio)ethyl]ester cytidine 5μ-(trihydrogen diphosphate) inner salt monosodium
  • Cytidine 5μ-diphosphocholine dihydrate sodium salt
  • Cytidine 5′-diphosphocholine sodium salt dihydrate,CDP-choline-Na, CDP-coline, Citicoline sodium, P′-[2-(Trimethylammonio)-ethyl]-ester cytidine 5′-(tri-hydro-gen di-phos-phate) inner salt monosodium
  • CITICOLINE SODIUM (CDP-COLINE/ CITIDINE (5I)-DIPHOSPHOCHOLINE)
  • Cytidine 5'-diphosphoric acid α-sodium β-[2-(trimethylammonio)ethyl] ester salt
  • Cytidine-5'-
  • 5′-CDP,Na
  • Acticolin
  • Brassel
  • Cebroton
  • Cidifos
  • Cytidine 5'-(Trihydrogen Diphosphate) P'-[2-(TriMethylaMMonio)ethyl] Ester Inner Salt SodiuM Salt
  • Flussorex
  • Gerolin
  • IP 302 SodiuM
  • Logan
  • Neurotron
  • Sinkron
  • Citicoline SodiuM API
  • CDPC (Citicoline MonosodiuM salt)
  • Citicoline sodiuM salt hydrate
  • sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxo-1-pyrimidinyl)-3,4-dihydroxy-2-oxolanyl]methoxy-oxidophosphoryl] 2-(trimethylammonio)ethyl phosphate
  • Citicoline Sodium (2 x 350 mg)
  • CDP .2Na