ChemicalBook > CAS DataBase List > 5-Amino-1,3,4-thiadiazole-2-thiol

5-Amino-1,3,4-thiadiazole-2-thiol

Product Name
5-Amino-1,3,4-thiadiazole-2-thiol
CAS No.
2349-67-9
Chemical Name
5-Amino-1,3,4-thiadiazole-2-thiol
Synonyms
2-Amino-5-mercapto-1,3,4-thiadiazole;2-Amino-5-mercapto-1,3,4-thiad;2-Mercapto-5-amino-1,3,4-thiadiazole;1,3,4-Thiadiazole-2(3H)-thione, 5-amino-;EAMTD;nsc21402;NSC 21402;usafpd-25;USAF pd-25;Acetazolamide EP Impurity G
CBNumber
CB1360123
Molecular Formula
C2H3N3S2
Formula Weight
133.2
MOL File
2349-67-9.mol
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5-Amino-1,3,4-thiadiazole-2-thiol Property

Melting point:
235 °C (dec.)(lit.)
Boiling point:
242.3±23.0 °C(Predicted)
Density 
1.503 (estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
2g/l
form 
Powder
pka
7.80±0.20(Predicted)
color 
White or pale yellow to cream
PH
3.9 (2g/l, H2O, 20℃)
Water Solubility 
insoluble
BRN 
81728
InChIKey
GDGIVSREGUOIJZ-UHFFFAOYSA-N
CAS DataBase Reference
2349-67-9(CAS DataBase Reference)
NIST Chemistry Reference
2-Amino-5-mercapto-1,3,4-thiadiazole(2349-67-9)
EPA Substance Registry System
1,3,4-Thiadiazole-2(3H)-thione, 5-amino- (2349-67-9)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22-20/21/22
Safety Statements 
26-36-36/37
WGK Germany 
3
RTECS 
XI4550000
F 
9-13-23
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
127906
Product name
5-Amino-1,3,4-thiadiazole-2-thiol
Purity
98%
Packaging
50g
Price
$88.6
Updated
2023/01/07
TCI Chemical
Product number
A0425
Product name
2-Amino-5-mercapto-1,3,4-thiadiazole
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$22
Updated
2025/07/31
TCI Chemical
Product number
A0425
Product name
2-Amino-5-mercapto-1,3,4-thiadiazole
Purity
>98.0%(HPLC)(T)
Packaging
500g
Price
$187
Updated
2025/07/31
TRC
Product number
A633300
Product name
5-Amino-1,3,4-thiadiazole-2-thiol
Packaging
1g
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
125517
Product name
2-Amino-5-mercapto-1,3,4-thiadiazole
Purity
97%
Packaging
10g
Price
$10
Updated
2021/12/16
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5-Amino-1,3,4-thiadiazole-2-thiol Chemical Properties,Usage,Production

Chemical Properties

White or pale yellow to cream powder

Uses

5-Amino-1,3,4-thiadiazole-2-thiol is a thiadiazole derivative with antibacterial acitivity used in the preparation of herbicides as well as carbonic anhydrase inhibitors.

Uses

5-amino-1,3,4-thiadiazole-2-thiol was used to prepare new amines exhibiting anti-convulsant activity.

Synthesis

75-15-0

79-19-6

2349-67-9

2-Amino-5-mercapto-1,3,4-thiadiazole was synthesized as follows: in a three-necked flask equipped with a stirrer, 5.5 g (0.06 mol) of aminothiourea, 20 mL of N,N-dimethylformamide (DMF), and 3 mL (0.1 mol) of carbon disulfide were added sequentially. The reaction mixture was heated to reflux and maintained for 4 hours. After completion of the reaction, the mixture was cooled to room temperature. To the reaction mixture was added 40 mL of 2 mol/L sodium hydroxide solution followed by decolorization. After decolorization, concentrated hydrochloric acid was slowly added to acidic conditions to precipitate the crude product. The crude product was purified by recrystallization from 50% ethanol to give 5.7 g of bright yellow needle-like crystals of 2-amino-5-mercapto-1,3,4-thiadiazole in 67.4% yield.

References

[1] Journal of Chemical Research, 2010, # 11, p. 619 - 621
[2] Chemical Biology and Drug Design, 2012, vol. 80, # 4, p. 598 - 604
[3] European Journal of Medicinal Chemistry, 2006, vol. 41, # 8, p. 918 - 924
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 2, p. 241 - 246
[5] Chemical Biology and Drug Design, 2013, vol. 81, # 5, p. 666 - 673

5-Amino-1,3,4-thiadiazole-2-thiol Preparation Products And Raw materials

Raw materials

2-Mercapto-5-methyl-1,3,4-thiadiazole Hydrazine sulfate Calcium phosphate RHENIUM Hydrazodicarbothioamide Ammonium thiocyanate

Preparation Products

2-(ACETAMIDO)-5-(CHLOROSULFONYL)-1,3,4-THIADIAZOLE 2-Acetylamino-5-mercapto-1,3,4-thiadiazole
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5-Amino-1,3,4-thiadiazole-2-thiol Suppliers

Americas 1 Belgium 2 Canada 1 China 383 Europe 5 Germany 6 India 24 Japan 4 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 8 United States 34 Global 472
TCI Europe
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320-37350700
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+32 (0)37350701
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sales@tcieurope.eu
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Europe
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ecochem international chemical broker
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Camida
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Europe
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View Lastest Price from 5-Amino-1,3,4-thiadiazole-2-thiol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
Henan Aochuang Chemical Co.,Ltd.
Product
5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Hebei Dangtong Import and export Co LTD
Product
5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9
Price
US $21.00-15.00/kg
Min. Order
10kg
Purity
98%
Supply Ability
300tons
Release date
2024-09-11

2349-67-9, 5-Amino-1,3,4-thiadiazole-2-thiolRelated Search:

2-Mercapto-5-methyl-1,3,4-thiadiazole 2,1,3-Benzothiadiazole 3-Mercaptopropionic acid 2-Mercapto-1,3,4-thiadiazol Glycine Calcium thioglycolate ALTRENOGEST 3-Aminophenol Sodium thioglycolate 2-Amino-1,3,4-thiadiazole 2-Ethylhexyl mercaptoacetate Mercaptoacetic acid 6-Aminocaproic acid Acetazolamide 2-Acetylamino-5-mercapto-1,3,4-thiadiazole ACETAZOLAMIDE-D3 Tris(hydroxymethyl)aminomethane N,N'-[IMinobis(sulfonyl-1,3,4-thiadiazole-5,2-diyl)]bisacetaMide

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