Ophthazin
- Product Name
- Ophthazin
- CAS No.
- 484-23-1
- Chemical Name
- Ophthazin
- Synonyms
- c7441;C8H1ON6;nepresol;Ophthazin;tonolysin;nepressol;hypopresol;nepresolin;NSC 526654;cassella532
- CBNumber
- CB1365502
- Molecular Formula
- C8H10N6
- Formula Weight
- 190.21
- MOL File
- 484-23-1.mol
Ophthazin Property
- Melting point:
- 180°C (rough estimate)
- Boiling point:
- 315.71°C (rough estimate)
- Density
- 1.3243 (rough estimate)
- refractive index
- 1.8100 (estimate)
- pka
- 3?+-.0.20(Predicted)
- color
- Orange crystals from H2O
Safety
- HS Code
- 2933998090
- Toxicity
- LD50 i.p. in rats: 1084 mmol/kg (Steiner)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- I779505
- Product name
- 1,4-Dihydraziny-phthalazine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- I779505
- Product name
- 1,4-Dihydraziny-phthalazine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0303601
- Product name
- 1,4-DIHYDRAZINO-PHTHALAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.32
- Updated
- 2021/12/16
- Product number
- 115247
- Product name
- 1,4-Dihydrazinyl-phthalazine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 115247
- Product name
- 1,4-Dihydrazinyl-phthalazine
- Purity
- >95%
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
Ophthazin Chemical Properties,Usage,Production
Originator
Nepresol,Novartis
Uses
Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
Definition
ChEBI: Dihydralazine is a member of phthalazines.
Manufacturing Process
115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.
Therapeutic Function
Antihypertensive
Safety Profile
Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.
Ophthazin Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71