Ophthazin

Product Name: Ophthazin
CAS No.: 484-23-1
Chemical Name: Ophthazin
Synonyms: c7441;C8H1ON6;nepresol;Ophthazin;tonolysin;nepressol;hypopresol;nepresolin;NSC 526654;cassella532
CBNumber: CB1365502
Molecular Formula: C8H10N6
Formula Weight: 190.21
MOL File: 484-23-1.mol

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Ophthazin Property

Melting point:: 180°C (rough estimate)
Boiling point:: 315.71°C (rough estimate)
Density: 1.3243 (rough estimate)
refractive index: 1.8100 (estimate)
pka: 3?+-.0.20(Predicted)
color: Orange crystals from H2O

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Safety

HS Code: 2933998090
Toxicity: LD50 i.p. in rats: 1084 mmol/kg (Steiner)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: I779505
Product name: 1,4-Dihydraziny-phthalazine
Packaging: 100mg
Price: $130
Updated: 2021/12/16

TRC

Product number: I779505
Product name: 1,4-Dihydraziny-phthalazine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0303601
Product name: 1,4-DIHYDRAZINO-PHTHALAZINE
Purity: 95.00%
Packaging: 5MG
Price: $495.32
Updated: 2021/12/16

Matrix Scientific

Product number: 115247
Product name: 1,4-Dihydrazinyl-phthalazine
Purity: >95%
Packaging: 500mg
Price: $132
Updated: 2021/12/16

Matrix Scientific

Product number: 115247
Product name: 1,4-Dihydrazinyl-phthalazine
Purity: >95%
Packaging: 1g
Price: $203
Updated: 2021/12/16

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Ophthazin Chemical Properties,Usage,Production

Originator

Nepresol,Novartis

Uses

Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Definition

ChEBI: Dihydralazine is a member of phthalazines.

Manufacturing Process

115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.

Therapeutic Function

Antihypertensive

Safety Profile

Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.

Ophthazin Preparation Products And Raw materials

Raw materials

Phthalazine

Preparation Products

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Ophthazin Suppliers

Canada 1 China 30 Europe 1 Germany 2 India 2 United Kingdom 3 United States 12 Global 51

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9639
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 7724
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

484-23-1, OphthazinRelated Search:

Dihydralazine sulphate Phthalazine Sofalcone Bismuth subcarbonate Magnesium trisilicate Nifedipine Minoxidil Losartan potassium guanethidine ZINC TELLURIDE HEXABROMOBENZENE Hydrochlorothiazide Pyridazine Phthalhydrazide Hydralazine Ophthazin

LABOTEST-BB LT00439820

DIHYDRALAZINE

Ophthazin

1,4-dihydrazinonaphthalazine

1,4-dihydrazino-phthalazin

1,4-dihydrazinophthalazine

2,3-dihydro-1,4-phthalazinedionedihydrazone

4-phthalazinedione,2,3-dihydro-dihydrazone

c7441

cassella532

tonolysin

dihydralazin

dihydrallazin

dihydrazinophthalazine

hypopresol

nepresol

nepresolin

nepressol

(4-hydrazinophthalazin-1-yl)hydrazine

(4-hydrazinylphthalazin-1-yl)hydrazine

1,4-dihydrazinyl-Phthalazine

NSC 526654

C8H1ON6

1,4-Dihydraziny-phthalazine

(1Z)-4-hydrazinyl-1-hydrazinylidene-1,2-dihydrophthalazine

Phthalazine, 1,4-dihydrazinyl-

Ophthazin USP/EP/BP

4-Hydrazinyl-1-hydrazinylidene-1,2- dihydrophthalazine

1,4-bis(hydrazino)phthalazine

1,4-dihydrazono-1,2,3,4-tetrahydrophthalazine

484-23-1

C8H10N6H2SO425H2O

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals