Ophthazin

Product Name: Ophthazin
CAS No.: 484-23-1
Chemical Name: Ophthazin
Synonyms: c7441;C8H1ON6;nepresol;Ophthazin;tonolysin;nepressol;hypopresol;nepresolin;NSC 526654;cassella532
CBNumber: CB1365502
Molecular Formula: C8H10N6
Formula Weight: 190.21
MOL File: 484-23-1.mol

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Ophthazin Property

Melting point:: 180°C (rough estimate)
Boiling point:: 315.71°C (rough estimate)
Density: 1.3243 (rough estimate)
refractive index: 1.8100 (estimate)
pka: 3?+-.0.20(Predicted)
color: Orange crystals from H2O

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Safety

HS Code: 2933998090
Toxicity: LD50 i.p. in rats: 1084 mmol/kg (Steiner)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: I779505
Product name: 1,4-Dihydraziny-phthalazine
Packaging: 100mg
Price: $130
Updated: 2021/12/16

TRC

Product number: I779505
Product name: 1,4-Dihydraziny-phthalazine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0303601
Product name: 1,4-DIHYDRAZINO-PHTHALAZINE
Purity: 95.00%
Packaging: 5MG
Price: $495.32
Updated: 2021/12/16

Matrix Scientific

Product number: 115247
Product name: 1,4-Dihydrazinyl-phthalazine
Purity: >95%
Packaging: 500mg
Price: $132
Updated: 2021/12/16

Matrix Scientific

Product number: 115247
Product name: 1,4-Dihydrazinyl-phthalazine
Purity: >95%
Packaging: 1g
Price: $203
Updated: 2021/12/16

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Ophthazin Chemical Properties,Usage,Production

Originator

Nepresol,Novartis

Uses

Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Definition

ChEBI: Dihydralazine is a member of phthalazines.

Manufacturing Process

115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.

Therapeutic Function

Antihypertensive

Safety Profile

Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.

Ophthazin Preparation Products And Raw materials

Raw materials

Phthalazine

Preparation Products

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Ophthazin Suppliers

Canada 1 China 32 Europe 1 Germany 2 India 2 United Kingdom 3 United States 12 Global 53

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484-23-1, OphthazinRelated Search:

Dihydralazine sulphate Phthalazine Sofalcone Bismuth subcarbonate Magnesium trisilicate Nifedipine Minoxidil Losartan potassium guanethidine ZINC TELLURIDE HEXABROMOBENZENE Hydrochlorothiazide Pyridazine Phthalhydrazide Hydralazine Ophthazin

LABOTEST-BB LT00439820

DIHYDRALAZINE

Ophthazin

1,4-dihydrazinonaphthalazine

1,4-dihydrazino-phthalazin

1,4-dihydrazinophthalazine

2,3-dihydro-1,4-phthalazinedionedihydrazone

4-phthalazinedione,2,3-dihydro-dihydrazone

c7441

cassella532

tonolysin

dihydralazin

dihydrallazin

dihydrazinophthalazine

hypopresol

nepresol

nepresolin

nepressol

(4-hydrazinophthalazin-1-yl)hydrazine

(4-hydrazinylphthalazin-1-yl)hydrazine

1,4-dihydrazinyl-Phthalazine

NSC 526654

C8H1ON6

1,4-Dihydraziny-phthalazine

(1Z)-4-hydrazinyl-1-hydrazinylidene-1,2-dihydrophthalazine

Phthalazine, 1,4-dihydrazinyl-

Ophthazin USP/EP/BP

4-Hydrazinyl-1-hydrazinylidene-1,2- dihydrophthalazine

1,4-bis(hydrazino)phthalazine

1,4-dihydrazono-1,2,3,4-tetrahydrophthalazine

484-23-1

C8H10N6H2SO425H2O

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals