METHOXAMINE HYDROCHLORIDE
- Product Name
- METHOXAMINE HYDROCHLORIDE
- CAS No.
- 61-16-5
- Chemical Name
- METHOXAMINE HYDROCHLORIDE
- Synonyms
- vasoxyl;Mexan;Vasylox;vasoxine;METHOXAMINE HCL;vasoxylhydrochloride;Naproxen Impurity 47;vasoxinehydrochloride;pressominhydrochloride;Methoxamine hydrochlorid
- CBNumber
- CB1380846
- Molecular Formula
- C11H18ClNO3
- Formula Weight
- 247.72
- MOL File
- 61-16-5.mol
METHOXAMINE HYDROCHLORIDE Property
- Melting point:
- 215℃
- refractive index
- 1.5204
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.2(at 25℃)
- form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 61-16-5(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- DN4025000
- Hazardous Substances Data
- 61-16-5(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- M6524
- Product name
- Methoxamine hydrochloride
- Packaging
- 500mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- M6524
- Product name
- Methoxamine hydrochloride
- Packaging
- 1g
- Price
- $336
- Updated
- 2024/03/01
- Product number
- M260740
- Product name
- MethoxamineHydrochloride(MixtureofDiastereomers)
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- API0003335
- Product name
- METHOXAMINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $538
- Updated
- 2021/12/16
- Product number
- 41303
- Product name
- MethoxamineHCl(MixtureofDiastereomers)
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
METHOXAMINE HYDROCHLORIDE Chemical Properties,Usage,Production
Originator
Vasoxyl ,Burroughs-Wellcome,US,1949
Uses
Antihypotensive;Alpha adrenergic agonist
Uses
Methoxamine is an α1-adrenergic receptor agonist. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure.
Uses
anti-fungal
Definition
ChEBI: Methoxamine hydrochloride is a dimethoxybenzene.
Manufacturing Process
2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.
Therapeutic Function
Hypertensive
Biochem/physiol Actions
α1-adrenoceptor agonist.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of HCl and NOx.
METHOXAMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHOXAMINE HYDROCHLORIDE manufacturers
- Product
- METHOXAMINE HYDROCHLORIDE 61-16-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-04