ACETYLCHOLINE BROMIDE Property

Melting point:

140-143 °C(lit.)

Density 

1.4246 (rough estimate)

refractive index 

1.6120 (estimate)

storage temp. 

-20°C

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

Off-White

Water Solubility 

almost transparency

Sensitive 

Hygroscopic

Merck 

14,86

BRN 

3572117

CAS DataBase Reference

66-23-9(CAS DataBase Reference)

EPA Substance Registry System

Acetylcholine bromide (66-23-9)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

FZ9680000

F 

3-8-10-23

HS Code 

29379000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

ACETYLCHOLINE BROMIDE Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT BEIGE ADHERING CRYSTALLINE SOLID

Uses

Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions. Acetylcholine bromide is used as an acetylcholine receptor agonist to identify, characterize and differentiate among types of cholinergic receptors. Acetylcholine bromide is used as an inhibitor to identify and characterize natural and mutated butyrylcholinesterase(s).

Definition

ChEBI: The bromide salt of acetylcholine.

Biochem/physiol Actions

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

Purification Methods

The bromide is a hygroscopic solid, but less so than the hydrochloride salt. It crystallises from EtOH as prisms. Some hydrolysis occurs in boiling EtOH, particularly if it contains some H2O. It can also be recrystallised from EtOH or MeOH by adding dry Et2O. [Heilbronn Acta Chem Scand 12 1492 1958, Beilstein 4 IV 1446.]