ChemicalBook > CAS DataBase List > AC-IETD-AFC

AC-IETD-AFC

Product Name
AC-IETD-AFC
CAS No.
211990-57-7
Chemical Name
AC-IETD-AFC
Synonyms
AC-IETD-AFC;AC-ILE-GLU-THR-ASP-AFC;Caspase 8 Substrate 1f;CGUOWXRXLQXOKO-FCQBACSVSA-N;M.W. 729.66 C31H38F3N5O12;CASPASE-8 FLUOROGENIC SUBSTRATE;CASPASE 8 SUBSTRATE 1F, FLUOROGENIC;GRANZYME B SUBSTRATE I, COLORIMETRIC;AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN;N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
CBNumber
CB1395556
Molecular Formula
C31H38F3N5O12
Formula Weight
729.65
MOL File
211990-57-7.mol
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AC-IETD-AFC Property

Boiling point:
1113.8±65.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
pka
4.09±0.10(Predicted)
form 
Lyophilized powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64258
Product name
N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin
Packaging
5mg
Price
$161
Updated
2021/12/16
Cayman Chemical
Product number
17480
Product name
Ac-IETD-AFC
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17480
Product name
Ac-IETD-AFC
Purity
≥95%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
17480
Product name
Ac-IETD-AFC
Purity
≥95%
Packaging
10mg
Price
$321
Updated
2024/03/01
TRC
Product number
A795613
Product name
Ac-IETD-AFC
Packaging
5mg
Price
$145
Updated
2021/12/16
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AC-IETD-AFC Chemical Properties,Usage,Production

Uses

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Uses

Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.

AC-IETD-AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-IETD-AFC Suppliers

China 58 Germany 2 Japan 1 Switzerland 1 United Kingdom 1 United States 13 Global 76
3B Pharmachem (Wuhan) International Co.,Ltd.
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GL Biochem (Shanghai) Ltd
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View Lastest Price from AC-IETD-AFC manufacturers

Career Henan Chemical Co
Product
AC-IETD-AFC 211990-57-7
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

211990-57-7, AC-IETD-AFCRelated Search:

GRANZYME B AC-IETD-CHO AC-IETD-AFC

  • CASPASE 8 SUBSTRATE 1F, FLUOROGENIC
  • CASPASE-8 FLUOROGENIC SUBSTRATE
  • GRANZYME B SUBSTRATE I, COLORIMETRIC
  • AC-IETD-AFC
  • AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
  • AC-ILE-GLU-THR-ASP-AFC
  • N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
  • N-ACETYL-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC
  • M.W. 729.66 C31H38F3N5O12
  • N-Acetyl-L-isoleucyl-L-alpha-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine
  • CGUOWXRXLQXOKO-FCQBACSVSA-N
  • Caspase 8 Substrate 1f
  • L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
  • Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin)
  • 211990-57-7
  • Caspase/Related Products
  • peptide
  • Caspases/Apoptosis