ChemicalBook > CAS DataBase List > AC-IETD-AFC

AC-IETD-AFC

Product Name: AC-IETD-AFC
CAS No.: 211990-57-7
Chemical Name: AC-IETD-AFC
Synonyms: AC-IETD-AFC;AC-ILE-GLU-THR-ASP-AFC;Caspase 8 Substrate 1f;CGUOWXRXLQXOKO-FCQBACSVSA-N;M.W. 729.66 C31H38F3N5O12;CASPASE-8 FLUOROGENIC SUBSTRATE;CASPASE 8 SUBSTRATE 1F, FLUOROGENIC;GRANZYME B SUBSTRATE I, COLORIMETRIC;AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN;N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
CBNumber: CB1395556
Molecular Formula: C31H38F3N5O12
Formula Weight: 729.65
MOL File: 211990-57-7.mol

Less

AC-IETD-AFC Property

Boiling point:: 1113.8±65.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 4.09±0.10(Predicted)
form: Lyophilized powder
color: White to off-white
Appearance: Solid Powder

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 17480
Product name: Ac-IETD-AFC
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17480
Product name: Ac-IETD-AFC
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 17480
Product name: Ac-IETD-AFC
Purity: ≥95%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

TRC

Product number: A795613
Product name: Ac-IETD-AFC
Packaging: 5mg
Price: $145
Updated: 2021/12/16

Less

AC-IETD-AFC Chemical Properties,Usage,Production

Description

Ac-IETD-AFC is a fluorogenic substrate for caspase-8 and caspase-3. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

Uses

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Uses

Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.

Excitation / Emission Maximum

400 nm/505 nm

Sequene

Ac-Ile-Glu-Thr-Asp-Unk

AC-IETD-AFC Preparation Products And Raw materials

Raw materials

Preparation Products

Less

AC-IETD-AFC Suppliers

China 75 Germany 2 Japan 1 Switzerland 1 United Kingdom 1 United States 13 Global 93

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 17801761073
Email: 3193328036@qq.com
Country: China
ProdList: 6338
Advantage: 68

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8618051385538
Email: donboo@donboo.com
Country: China
ProdList: 9363
Advantage: 58

Nanjing Yuanpeptide Biotech Co.，Ltd.

Tel: 18168071971
Email: support@yuan-peptide.com
Country: China
ProdList: 2983
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6979
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 13770887460
Email: wenxi@jszkhy.com
Country: China
ProdList: 1354
Advantage: 58

Nanjing Yushengkang Biotechnology Co., Ltd

Tel: 13327808530
Email: 2670965693@qq.com
Country: China
ProdList: 2179
Advantage: 58

Hangzhou Beiputai Biopharmaceutical Co., Ltd

Tel: 0571-85350119 15888826472
Email: bptsales@163.com
Country: China
ProdList: 3834
Advantage: 58

xinguokeji

Tel: 13120711461
Email: 363372932@qq.com
Country: China
ProdList: 498
Advantage: 58

Xi'an Biolite Biotech, Inc.

Tel: 029-029-68064558 18502920169
Email: xiaodong@tjbiolite.com
Country: China
ProdList: 2777
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Hangzhou ALLPEPTIDE Biotechnology Co., Ltd.

Tel: 17342063383
Email: sales@allpeptide.com
Country: China
ProdList: 5320
Advantage: 58

YantaiBio

Tel: 13758194781 15083780366
Email: wudegui@tanzhenbio.com
Country: China
ProdList: 1591
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 18270980682
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 1790
Advantage: 58

LEON (NANJING) BIOTECHNOLOGY CO., LTD.

Tel: +8615051830413
Email: sales.njleonbiotech@gmail.com
Country: China
ProdList: 5482
Advantage: 58

Guangzhou Xuze Biotechnology Co., Ltd.

Tel: 17817710394
Country: CHINA
ProdList: 167
Advantage: 58

Guangzhou Paisen Biotechnology Co., Ltd

Tel: 18122440496
Country: CHINA
ProdList: 142
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

Guangzhou Biopark Technology Co., Ltd.

Tel: 020-83808789
Country: CHINA
ProdList: 179
Advantage: 58

Jinan Dingguo Biotechnology Co., Ltd.

Tel: 053181181593
Country: CHINA
ProdList: 155
Advantage: 58

Guangzhou Keda Heng New Technology Co., Ltd.

Tel: 17328662120
Country: CHINA
ProdList: 139
Advantage: 58

Guangzhou Ruifeng Biotechnology Co., Ltd.

Tel: 14715141318
Country: CHINA
ProdList: 181
Advantage: 58

Guangzhou Chuangze Biotechnology Co., Ltd.

Tel: 18312220236
Country: CHINA
ProdList: 178
Advantage: 58

Guangzhou Nishuo Trading Co., Ltd

Tel: 18026280618
Country: CHINA
ProdList: 187
Advantage: 58

Guangzhou Ruifan Biotechnology Co., Ltd.

Tel: 18122249824
Country: CHINA
ProdList: 132
Advantage: 58

Guangzhou Tuoshan Biotechnology Co., Ltd.

Tel: 19928332050
Country: CHINA
ProdList: 161
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Qiangyao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: caiwuchinapeptides@126.com
Country: CHINA
ProdList: 1253
Advantage: 58

Dongguan Runbo Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: runbobiological@163.com
Country: CHINA
ProdList: 5941
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Shanghai Aiyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 842460171@qq.com
Country: CHINA
ProdList: 1115
Advantage: 58

Less

View Lastest Price from AC-IETD-AFC manufacturers

Career Henan Chemical Co

Product: AC-IETD-AFC 211990-57-7
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

211990-57-7, AC-IETD-AFCRelated Search:

GRANZYME B AC-IETD-CHO AC-IETD-AFC

CASPASE 8 SUBSTRATE 1F, FLUOROGENIC

CASPASE-8 FLUOROGENIC SUBSTRATE

GRANZYME B SUBSTRATE I, COLORIMETRIC

AC-IETD-AFC

AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN

AC-ILE-GLU-THR-ASP-AFC

N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)

N-ACETYL-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC

M.W. 729.66 C31H38F3N5O12

N-Acetyl-L-isoleucyl-L-alpha-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine

CGUOWXRXLQXOKO-FCQBACSVSA-N

Caspase 8 Substrate 1f

L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-

Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin)

(4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-5-[[(3R)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

211990-57-7

Caspase/Related Products

peptide

Caspases/Apoptosis