Orphenadrine
- Product Name
- Orphenadrine
- CAS No.
- 83-98-7
- Chemical Name
- Orphenadrine
- Synonyms
- C07935;Disipal;WS 2434;Biorphen;Orphenadine;Orphenadrin;Orphenedrine;orphenadrine;AURORA KA-7797;Ophenadrinecitrate
- CBNumber
- CB1397020
- Molecular Formula
- C18H23NO
- Formula Weight
- 269.38
- MOL File
- 83-98-7.mol
Orphenadrine Property
- Melting point:
- 25°C
- Boiling point:
- bp12 195°
- Density
- 1.0278 (rough estimate)
- refractive index
- 1.5740 (estimate)
- pka
- pKa 8.4 (Uncertain)
- form
- Solid
- Water Solubility
- 1.801mg/L(22.5 ºC)
- CAS DataBase Reference
- 83-98-7
Safety
- RIDADR
- 1851
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 83-98-7(Hazardous Substances Data)
- Toxicity
- LD50 oral in mouse: 125mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0000039
- Product name
- ORPHENADRINE RELATED COMPOUND C
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $525
- Updated
- 2021/12/16
- Product number
- API0000039
- Product name
- ORPHENADRINE RELATED COMPOUND C
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1370.41
- Updated
- 2021/12/16
Orphenadrine Chemical Properties,Usage,Production
Originator
Norflex,Riker,US,1959
Uses
Relaxant (skeletal muscle); antihistaminic.
Definition
ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
brand name
Norflex (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant
Enzyme inhibitor
This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamineclass antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target(s): aldehyde oxidase; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor; noradrenaline reuptake.
Orphenadrine Preparation Products And Raw materials
Raw materials
Preparation Products
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