Orphenadrine

Product Name: Orphenadrine
CAS No.: 83-98-7
Chemical Name: Orphenadrine
Synonyms: C07935;Disipal;WS 2434;Biorphen;Orphenadine;Orphenadrin;Orphenedrine;orphenadrine;AURORA KA-7797;Ophenadrinecitrate
CBNumber: CB1397020
Molecular Formula: C18H23NO
Formula Weight: 269.38
MOL File: 83-98-7.mol

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Orphenadrine Property

Melting point:: 25°C
Boiling point:: bp12 195°
Density: 1.0278 (rough estimate)
refractive index: 1.5740 (estimate)
pka: pKa 8.4 (Uncertain)
form: Solid
Water Solubility: 1.801mg/L(22.5 ºC)
CAS DataBase Reference: 83-98-7

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Safety

RIDADR: 1851
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 83-98-7(Hazardous Substances Data)
Toxicity: LD50 oral in mouse: 125mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0000039
Product name: ORPHENADRINE RELATED COMPOUND C
Purity: 95.00%
Packaging: 1G
Price: $525
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000039
Product name: ORPHENADRINE RELATED COMPOUND C
Purity: 95.00%
Packaging: 5G
Price: $1370.41
Updated: 2021/12/16

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Orphenadrine Chemical Properties,Usage,Production

Originator

Norflex,Riker,US,1959

Uses

Relaxant (skeletal muscle); antihistaminic.

Definition

ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.

Manufacturing Process

As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.

brand name

Norflex (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant

Enzyme inhibitor

This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamineclass antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target(s): aldehyde oxidase; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor; noradrenaline reuptake.

Orphenadrine Preparation Products And Raw materials

Raw materials

Preparation Products

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Orphenadrine Suppliers

Austria 1 Canada 1 China 27 Germany 2 India 5 United States 7 Global 43

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2982
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

83-98-7, OrphenadrineRelated Search:

Toluenesulfonamide o-Toluic acid O-toluenediamine Bufenadrine Oxitriptyline Ciheptolane Orphenadrine citrate N-METHYLORPHENADRINE METHOSULFATE 2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE HYDROCHLORIDE m-(alpha-(2-(Dimethylamino)ethoxy)-o-methylbenzyl)phenol maleate SPECS AE-641/11703040 spiroxepin Orphenadrine

O-METHYLDIPHENHYDRAMINE

PHENYL-O-TOLYLMETHYL DIMETHYLAMINOETHYL ETHER

2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE

2-Methyldiphenhydramine

beta-Dimethylaminoethyl-2-methylbenzhydryl ether

Biorphen

Disipal

Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-

Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-

N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine

N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine

Orphenadine

Orphenadrin

Orphenedrine

WS 2434

2-dimethylaminoethyl 2-methylbenzhydryl ether

orphenadrine

AURORA KA-7797

B-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER

N,N-Dimethyl-2-[(2-methyl-α-phenylbenzyl)oxy]ethanamine

N,N-Dimethyl-2-[(o-methyl-α-phenylbenzyl)oxy]ethanamine

N,N-Dimethyl-2-[[α-(2-methylphenyl)benzyl]oxy]ethylamine

Ophenadrinecitrate

Orphenadrine (base and/or unspecified salts)

C07935

ORPHENADRINE RELATED COMPOUND C

Orphenadrine USP/EP/BP

Orphenadrine free base

Orphenadrine-d3 HCl

OrphenadrineQ: What is Orphenadrine Q: What is the CAS Number of Orphenadrine Q: What is the storage condition of Orphenadrine

ORPHEDRINE FREE BASE

83-98-7

Cd9H23NO