Orphenadrine

Product Name: Orphenadrine
CAS No.: 83-98-7
Chemical Name: Orphenadrine
Synonyms: C07935;Disipal;WS 2434;Biorphen;Orphenadine;Orphenadrin;Orphenedrine;orphenadrine;AURORA KA-7797;Ophenadrinecitrate
CBNumber: CB1397020
Molecular Formula: C18H23NO
Formula Weight: 269.38
MOL File: 83-98-7.mol

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Orphenadrine Property

Melting point:: 25°C
Boiling point:: bp12 195°
Density: 1.0278 (rough estimate)
refractive index: 1.5740 (estimate)
pka: pKa 8.4 (Uncertain)
form: Solid
color: Light yellow to brown
Water Solubility: 1.801mg/L(22.5 ºC)
CAS DataBase Reference: 83-98-7

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Safety

RIDADR: 1851
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 83-98-7(Hazardous Substances Data)
Toxicity: LD50 oral in mouse: 125mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0000039
Product name: ORPHENADRINE RELATED COMPOUND C
Purity: 95.00%
Packaging: 1G
Price: $525
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000039
Product name: ORPHENADRINE RELATED COMPOUND C
Purity: 95.00%
Packaging: 5G
Price: $1370.41
Updated: 2021/12/16

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Orphenadrine Chemical Properties,Usage,Production

Originator

Norflex,Riker,US,1959

Uses

Relaxant (skeletal muscle); antihistaminic.

Definition

ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.

Manufacturing Process

As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.

brand name

Norflex (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant

Enzyme inhibitor

This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamineclass antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target(s): aldehyde oxidase; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor; noradrenaline reuptake.

Orphenadrine Preparation Products And Raw materials

Raw materials

Preparation Products

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83-98-7, OrphenadrineRelated Search:

Toluenesulfonamide o-Toluic acid O-toluenediamine Bufenadrine Oxitriptyline Ciheptolane Orphenadrine citrate N-METHYLORPHENADRINE METHOSULFATE 2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE HYDROCHLORIDE m-(alpha-(2-(Dimethylamino)ethoxy)-o-methylbenzyl)phenol maleate SPECS AE-641/11703040 spiroxepin Orphenadrine

O-METHYLDIPHENHYDRAMINE

PHENYL-O-TOLYLMETHYL DIMETHYLAMINOETHYL ETHER

2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE

2-Methyldiphenhydramine

beta-Dimethylaminoethyl-2-methylbenzhydryl ether

Biorphen

Disipal

Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-

Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-

N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine

N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine

Orphenadine

Orphenadrin

Orphenedrine

WS 2434

2-dimethylaminoethyl 2-methylbenzhydryl ether

orphenadrine

AURORA KA-7797

B-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER

N,N-Dimethyl-2-[(2-methyl-α-phenylbenzyl)oxy]ethanamine

N,N-Dimethyl-2-[(o-methyl-α-phenylbenzyl)oxy]ethanamine

N,N-Dimethyl-2-[[α-(2-methylphenyl)benzyl]oxy]ethylamine

Ophenadrinecitrate

Orphenadrine (base and/or unspecified salts)

C07935

ORPHENADRINE RELATED COMPOUND C

Orphenadrine USP/EP/BP

Orphenadrine free base

Orphenadrine-d3 HCl

OrphenadrineQ: What is Orphenadrine Q: What is the CAS Number of Orphenadrine Q: What is the storage condition of Orphenadrine

ORPHEDRINE FREE BASE

83-98-7

Cd9H23NO