Orphenadrine citrate
- Product Name
- Orphenadrine citrate
- CAS No.
- 4682-36-4
- Chemical Name
- Orphenadrine citrate
- Synonyms
- X-Ota;Flexon;X-Otag;Banflex;Benhexal;Flexoject;Einecs 225-137-5;Orphenadrine citrate;ORPHENADRINECITRATE,USP;Orphenadrine citrate CRS
- CBNumber
- CB3401680
- Molecular Formula
- C24H31NO8
- Formula Weight
- 461.5
- MOL File
- 4682-36-4.mol
Orphenadrine citrate Property
- Melting point:
- 132-1340C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Sparingly soluble in water, slightly soluble in ethanol (96 per cent).
- form
- Solid
- color
- White to Pale Beige
- InChIKey
- ASDBZPGDZBFZAH-UHFFFAOYSA-N
- CAS DataBase Reference
- 4682-36-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-40-20/21/22
- Safety Statements
- 22-36-62-38-36/37/39-28-26-24/25
- RIDADR
- 3249
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2922190900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- O4630
- Product name
- Orphenadrine citrate salt
- Purity
- analytical standard
- Packaging
- 5g
- Price
- $44.82
- Updated
- 2024/03/01
- Product number
- 1479009
- Product name
- Orphenadrine citrate salt
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- Y0000101
- Product name
- Orphenadrine citrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000101
- Price
- $153
- Updated
- 2024/03/01
- Product number
- PHR1777
- Product name
- Orphenadrine citrate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- O695300
- Product name
- Orphenadrine citrate salt
- Packaging
- 25g
- Price
- $495
- Updated
- 2021/12/16
Orphenadrine citrate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Norflex,Riker,US,1959
Uses
Muscle relaxant (skeletal); antihistaminic
Uses
skeletal muscle relaxant, antihistaminic agent
Uses
A histaminergic compound
Definition
ChEBI: A citrate salt which comprises equimolar amounts of orphenadrine and citric acid.
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
brand name
Norflex (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant
General Description
Orphenadrine citrate, N,Ndimethyl-2-(o-methyl-α-phenylbenzyloxy)ethylamine citrate(1:1) (Norflex), introduced in 1957, is closely related todiphenhydramine structurally but has much lower antihistaminicactivity and much higher anticholinergic action.Likewise, it lacks the sedative effects characteristic ofdiphenhydramine. Pharmacological testing indicates that itis not primarily a peripherally acting anticholinergic becauseit has only weak effects on smooth muscle, on the eye,and on secretory glands. It does reduce voluntary musclespasm, however, by a central inhibitory action on cerebralmotor areas, a central effect similar to that of atropine.
Clinical Use
Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).
The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.
Orphenadrine citrate Preparation Products And Raw materials
Raw materials
Preparation Products
Orphenadrine citrate Suppliers
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View Lastest Price from Orphenadrine citrate manufacturers
- Product
- Benoxinate Hydrochloride 4682-36-4
- Price
- US $19.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-22
- Product
- Orphenadrine Citrate 4682-36-4
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-06
- Product
- Orphenadrine Citrate 4682-36-4
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2022-01-07