ChemicalBook > CAS DataBase List > Orphenadrine citrate

Orphenadrine citrate

Product Name
Orphenadrine citrate
CAS No.
4682-36-4
Chemical Name
Orphenadrine citrate
Synonyms
X-Ota;Flexon;X-Otag;Banflex;Benhexal;Flexoject;Einecs 225-137-5;Orphenadrine citrate;ORPHENADRINECITRATE,USP;Orphenadrine citrate CRS
CBNumber
CB3401680
Molecular Formula
C24H31NO8
Formula Weight
461.5
MOL File
4682-36-4.mol
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Orphenadrine citrate Property

Melting point:
132-1340C
storage temp. 
Sealed in dry,2-8°C
solubility 
Sparingly soluble in water, slightly soluble in ethanol (96 per cent).
form 
Solid
color 
White to Pale Beige
InChIKey
ASDBZPGDZBFZAH-UHFFFAOYSA-N
CAS DataBase Reference
4682-36-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-40-20/21/22
Safety Statements 
22-36-62-38-36/37/39-28-26-24/25
RIDADR 
3249
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2922190900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O4630
Product name
Orphenadrine citrate salt
Purity
analytical standard
Packaging
5g
Price
$44.82
Updated
2024/03/01
Sigma-Aldrich
Product number
1479009
Product name
Orphenadrine citrate salt
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000101
Product name
Orphenadrine citrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000101
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1777
Product name
Orphenadrine citrate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$179
Updated
2024/03/01
TRC
Product number
O695300
Product name
Orphenadrine citrate salt
Packaging
25g
Price
$495
Updated
2021/12/16
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Orphenadrine citrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Norflex,Riker,US,1959

Uses

Muscle relaxant (skeletal); antihistaminic

Uses

skeletal muscle relaxant, antihistaminic agent

Uses

A histaminergic compound

Definition

ChEBI: A citrate salt which comprises equimolar amounts of orphenadrine and citric acid.

Manufacturing Process

As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.

brand name

Norflex (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant

General Description

Orphenadrine citrate, N,Ndimethyl-2-(o-methyl-α-phenylbenzyloxy)ethylamine citrate(1:1) (Norflex), introduced in 1957, is closely related todiphenhydramine structurally but has much lower antihistaminicactivity and much higher anticholinergic action.Likewise, it lacks the sedative effects characteristic ofdiphenhydramine. Pharmacological testing indicates that itis not primarily a peripherally acting anticholinergic becauseit has only weak effects on smooth muscle, on the eye,and on secretory glands. It does reduce voluntary musclespasm, however, by a central inhibitory action on cerebralmotor areas, a central effect similar to that of atropine.

Clinical Use

Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).
The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.

Orphenadrine citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Orphenadrine citrate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Benoxinate Hydrochloride 4682-36-4
Price
US $19.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-22
Shaanxi Dideu Medichem Co. Ltd
Product
Orphenadrine Citrate 4682-36-4
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-06
Hebei Zhanyao Biotechnology Co. Ltd
Product
Orphenadrine Citrate 4682-36-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2022-01-07

4682-36-4, Orphenadrine citrateRelated Search:

Citric acid monohydrate 2-Nitrotoluene 2-Methylbenzotrifluoride Citric acid Sildenafil citrate N,N-Dimethyl-1,4-phenylenediamine Anisole Orphenadrine Diphenhydramine 4-Methoxyphenol Sodium citrate Calcium citrate Ethylbenzene Potassium Citrate N,N-Dimethylformamide o-Xylene 4-Methylanisole 2-Nitro-4-methylsulfonyltoluene

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  • Orphenadrine citrateQ: What is Orphenadrine citrate Q: What is the CAS Number of Orphenadrine citrate Q: What is the storage condition of Orphenadrine citrate Q: What are the applications of Orphenadrine citrate
  • Orphenadrine Citrate (1479009)
  • 4682-36-4
  • C24H31NO8
  • C18H23NOC6H8O7
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