Ramosetron hydrochloride
- Product Name
- Ramosetron hydrochloride
- CAS No.
- 132907-72-3
- Chemical Name
- Ramosetron hydrochloride
- Synonyms
- ym060;Nasea OD;(R)-YM-060;RAMOSETRON HCL;YM-060;YM060;YM 060;(r)-monohydrochlorid;Ramosetron Hydrochlorid;Ramosetron hydrocloride;RAMOSETRON HYDROCHLORIDE;Ramosetron hydrochloride (API)
- CBNumber
- CB1397525
- Molecular Formula
- C17H18ClN3O
- Formula Weight
- 315.8
- MOL File
- 132907-72-3.mol
Ramosetron hydrochloride Property
- Melting point:
- 244-246°C
- alpha
- D -42.9° (c 1.02 in methanol)
- storage temp.
- -20°C
- solubility
- H2O: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -40 to -45°, c = 1 in methanol
- Stability:
- Hygroscopic
- InChIKey
- XIXYTCLDXQRHJO-RFVHGSKJSA-N
- CAS DataBase Reference
- 132907-72-3(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- SML0674
- Product name
- Ramosetron hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $91.6
- Updated
- 2024/03/01
- Product number
- SML0674
- Product name
- Ramosetron hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $354
- Updated
- 2024/03/01
- Product number
- 15548
- Product name
- Ramosetron (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 15548
- Product name
- Ramosetron (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 15548
- Product name
- Ramosetron (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $286
- Updated
- 2024/03/01
Ramosetron hydrochloride Chemical Properties,Usage,Production
Description
Ramosetron Hydrochloride is the only currently available drug indicated for the treatment of male patients with IBS-D in Japan. Ramosetron Hydrochloride was approved in July 1996 under a brand name of Nasea Injection 0.3 mg and in June 1998 under a brand name of Nasea OD tablets 0.1 mg for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with therapy with antineoplastic drugs (e.g., cisplatin).
Nasea was launched in Japan for chemotherapy-induced emesis. Nasea was prepared by a four step sequence via the Vilsmeier-type coupling of 1-methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl-benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.
Chemical Properties
White Solid
Originator
Yamanouchi (Japan)
Uses
Ramosetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist and has structurally different from Ondansetron (O655000), Granisetron (G780000). It controls excessive bowel movement and diarrhea by inhibiting 5-HT3 receptors in the intestinal tract. Ramosetron Hydrochloride was approved as film-coated tablets in July 2008 and as orally disintegrating tablets in August 2013 for the indication of treatment of male patients with diarrhea-predominant irritable bowel syndrome.
Definition
ChEBI: Ramosetron hydrochloride is a member of indoles.
brand name
Nasea
Biochem/physiol Actions
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively. this pharmacologic property confers the drug an application in improving diarrhea-predominant inflammatory bowel syndrome. Ramosetron hydrochloride is used for PONV prophylaxis and treatment. However, ramosetron is currently only licenced for use in Japan and selected Southeast Asian countries.
Ramosetron hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ramosetron hydrochloride Suppliers
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View Lastest Price from Ramosetron hydrochloride manufacturers
- Product
- Ramosetron Hydrochlorid 132907-72-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-07-24
- Product
- Ramosetron hydrochloride 132907-72-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.5%
- Supply Ability
- 10kg/month
- Release date
- 2021-06-17
- Product
- Ramosetron hydrochloride 132907-72-3
- Price
- US $10.00-8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-07