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2,6-DIBROMOANISOLE

Product Name
2,6-DIBROMOANISOLE
CAS No.
38603-09-7
Chemical Name
2,6-DIBROMOANISOLE
Synonyms
2,6-DIBROMOANISOLE;2,6-Dibromoanisole,>97%;2,6-Dibromo-1-methoxybenzene;1,3-Dibromo-2-methoxybenzene;Benzene,1,3-dibroMo-2-Methoxy-
CBNumber
CB1397570
Molecular Formula
C7H6Br2O
Formula Weight
265.93
MOL File
38603-09-7.mol
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2,6-DIBROMOANISOLE Property

Melting point:
13°C
Boiling point:
254℃
Density 
1.823
refractive index 
1.5920 to 1.5960
Flash point:
100℃
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow
InChI
InChI=1S/C7H6Br2O/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3
InChIKey
BMZVDHQOAJUZJL-UHFFFAOYSA-N
SMILES
C1(Br)=CC=CC(Br)=C1OC
CAS DataBase Reference
38603-09-7
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Safety

HS Code 
2909303840
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5279
Product name
2,6-Dibromoanisole
Purity
>98.0%(GC)
Packaging
1g
Price
$76
Updated
2025/07/31
TCI Chemical
Product number
D5279
Product name
2,6-Dibromoanisole
Purity
>98.0%(GC)
Packaging
5g
Price
$227
Updated
2025/07/31
TRC
Product number
D422975
Product name
2,6-Dibromoanisole
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
D422975
Product name
2,6-Dibromoanisole
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD142831
Product name
1,3-Dibromo-2-methoxybenzene
Packaging
250mg
Price
$62.5
Updated
2021/12/16
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2,6-DIBROMOANISOLE Chemical Properties,Usage,Production

Uses

2,6-Dibromoanisole is an anisole compound containing a substituent bromine atom that can be used in bromine substitution reactions to prepare other organic ether derivatives. It is also a Lusutrombopag intermediate, which is used to treat thrombocytopenia (low platelets in the blood) in adult patients with chronic liver disease who are scheduled to undergo medical or dental procedures.

Synthesis

608-33-3

74-88-4

38603-09-7

Example 1 Preparation of 2,6-dibromo-4-(6-(3-bromobenzyloxy)pyridazin-3-yl)phenol (Compound 91): to a stirred solution of 2,6-dibromophenol (5.26 g, 20.9 mmol) in acetone (170 mL) was added anhydrous potassium carbonate (4.33 g, 31.3 mmol) and the mixture was stirred at room temperature for 30 minutes. Iodomethane (1.97 mL, 31.4 mmol) was then added and the reaction mixture was heated to reflux at 60 °C for 3 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated by rotary evaporation. The residue was extracted by partitioning between petroleum ether (40-60 °C, 100 mL) and water (100 mL). The aqueous layer was extracted once more with petroleum ether (40-60 °C, 100 mL), and the organic phases were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated to afford 5.43 g (98% yield) of the target compound, 1 ,3-dibromo-2-methoxybenzene, as a colorless oil.1H NMR (CDCl3, δ ppm): 3.89 (3H, s), 6.86 (1H, t, J = 8.02 Hz), 7.50 (2H, d, J = 8.01 Hz).

References

[1] Tetrahedron Letters, 2008, vol. 49, # 33, p. 4912 - 4914
[2] Patent: US2009/270398, 2009, A1. Location in patent: Page/Page column 35
[3] Journal of the American Chemical Society, 2009, vol. 131, # 47, p. 17371 - 17375
[4] Journal of the American Chemical Society, 2016, vol. 138, # 31, p. 9779 - 9782
[5] Patent: WO2009/103440, 2009, A1. Location in patent: Page/Page column 75

2,6-DIBROMOANISOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DIBROMOANISOLE Suppliers

Americas 1 Austria 1 Canada 1 China 103 Europe 1 Germany 3 India 2 Japan 1 Norway 1 United Kingdom 5 United States 12 Global 131
Carbosynth
Tel
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Email
sales@carbosynth.com
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United Kingdom
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6005
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58
Leancare Ltd.
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enquiry@leancare.co.uk
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United Kingdom
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6446
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Apollo Scientific Ltd.
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sales@apolloscientific.co.uk
Country
United Kingdom
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MOLEKULA Ltd.
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kevinbanks@molekula.com
Country
United Kingdom
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6140
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CARBONE SCIENTIFIC CO.,LTD
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Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
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View Lastest Price from 2,6-DIBROMOANISOLE manufacturers

Career Henan Chemical Co
Product
2,6-DIBROMOANISOLE 38603-09-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-24

38603-09-7, 2,6-DIBROMOANISOLERelated Search:

2-Allyloxy-1,3,5-tribromobenzene 2,4,6-TRIBROMOPHENYL ACETATE Decabromodiphenyl oxide 1,2-Bis(2,4,6-tribromophenoxy)ethane BROMOXYNIL-METHYL ETHER 4,4'-Isopropylidenebis[2-(2,6-dibromophenoxy)ethanol] Bromoxynil octanoate Tetrabromobisphenol A bis(dibromopropyl ether) TRIBROMONEOPENTYL METHACRYLATE 3,5-DIBROMOANISOLE 2,4-DIBROMOANISOLE,2,4-Dibromoanisole, 98+%,4,6-Dibromoanisole 2,4-Dibromoanisole-5-boronic acid 2,4-Dibromoanisole-3-boronic acid 2,5-DIBROMOANISOLE BOC-3,5-DIBROMO-TYR(OBZL)-OH 2,4,6-TRIBROMO-3-METHOXYPHENOL 2,6-DIBROMO-4-FLUOROANISOLE 3,5-DIBROMO-4-METHOXYBENZOIC ACID

  • 1,3-Dibromo-2-methoxybenzene
  • 2,6-Dibromo-1-methoxybenzene
  • 2,6-DIBROMOANISOLE
  • Benzene,1,3-dibroMo-2-Methoxy-
  • 2,6-Dibromoanisole,>97%
  • 38603-09-7
  • Anisole