Calcipotriene

ChemicalBook > CAS DataBase List > Calcipotriene

Product Name: Calcipotriene
CAS No.: 112828-00-9
Chemical Name: Calcipotriene
Synonyms: Carpotriol;Calcipotrien;CALCIPOTRIOL;Calcipotriene;Calcipotriene API;Calcipotriene USP/EP/BP;Calcipotriene/calcipotriol;24-CYCLOPROPYL-(1ALPHA,3BETA,5Z,7E,22E,24S)-9,10-SECOCHOLA-5,7,10(19),22-TETRAENE-1,3,24-TRIOL;(1R,3S,5Z)-5-{2-[(4E)-1-[(2R,3E,5R)-5-CYCLOPROPYL-5-HYDROXYPENT-3-EN-2-YL]-7A-METHYL-HEXAHYDRO-1H-IN;(1r,3s,5z)-5-[(2e)-2-[1-[(e,2r,5r)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CBNumber: CB1412712
Molecular Formula: C27H40O3
Formula Weight: 412.6
MOL File: 112828-00-9.mol

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Calcipotriene Property

CAS DataBase Reference: 112828-00-9(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Purity: ≥98%
Packaging: 10mg
Price: $56
Updated: 2021/12/16

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Purity: ≥98%
Packaging: 50mg
Price: $252
Updated: 2021/12/16

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Purity: ≥98%
Packaging: 100mg
Price: $448
Updated: 2021/12/16

Cayman Chemical

Product number: 10009599
Product name: Calcipotriol (hydrate)
Purity: ≥98%
Packaging: 500mg
Price: $1960
Updated: 2021/12/16

Tocris

Product number: 2700
Product name: Calcipotriol
Purity: ≥98%(HPLC)
Packaging: 50
Price: $889
Updated: 2021/12/16

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Calcipotriene Chemical Properties,Usage,Production

Uses

Antipsoriatic.

Indications

Calcipotriene (calcipotriol) is a synthetic vitamin D3 derivative that is useful for the treatment of patients with moderate plaque psoriasis. Its effects are comparable with those of class II topical steroids, without the associated adverse effects. Its mechanism of action involves both induction of terminal differentiation of keratinocytes and inhibition of keratinocyte production. It should be applied to the face with care, as this region is more susceptible to irritation, burning, and itching, as seen in approximately 10% of patients. Other adverse effects include erythema, peeling, xerosis, dermatitis, or worsening psoriasis in 1% to 10% of patients. Fewer than 1% of patients experience hypercalcemia, atrophy, hyperpigmentation, or folliculitis. Allergic contact dermatitis to calcipotriene has been reported.
Most patients demonstrate improvement after 2 weeks; 70% of patients improve after 8 weeks, with 10% showing complete clearing. It should be avoided in patients with documented impairment in calcium metabolism, hypercalcemia, vitamin D toxicity, or history of renal stones.
Calcipotriene may be used as an adjuvant with psoralens plus ultraviolet A (PUVA) and ultraviolet B (UVB). Pretreatment with or subsequent addition of calcipotriol to PUVA reduces the cumulative doses of UVA needed to achieve >75% reduction in severity and distribution of psoriasis.

Definition

ChEBI: Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as a drug allergen and an antipsoriatic. It is a member of cyclopropanes, a secondary alcohol, a triol, a hydroxy seco-steroid and a seco-cholestane.

brand name

Dovonex (Leo).

Calcipotriene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Calcipotriene manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Calcipotriol 112828-00-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0%min. HPLC
Supply Ability: 1000kg
Release date: 2022-11-08

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Calcipotriene 112828-00-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

airuikechemical co., ltd.

Product: Calcipotriene 112828-00-9
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

112828-00-9, CalcipotrieneRelated Search:

CALCIPOTRIOL MONOHYDRATE (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one Paricalcitol Vitamin E TRISTEARIN DICHLOFLUANID Polyvinylpyrrolidone Emamectin D-Glucurone Sofalcone Sodium chloride CLODRONIC ACID Maxacalcitol Tapinarof Sodium lactate Tacrolimus CALCIPOTRIOL,CALCIPOTRIENE,Calcipotriene Calcipotriene

Calcipotrien

(1R,3S,5Z)-5-[(2E)-2-[(1R,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylenecyclohexane-1,3-diol

(1R,3S,5Z)-5-{2-[(4E)-1-[(2R,3E,5R)-5-CYCLOPROPYL-5-HYDROXYPENT-3-EN-2-YL]-7A-METHYL-HEXAHYDRO-1H-IN

Calcipotriene/calcipotriol

CALCIPOTRIOL

(1s,3s,5z)-5-[(2e)-2-[(1r,3ar,7ar)-1-[(e,2s)-5-cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol

(1r,3s,5z)-5-[(2e)-2-[1-[(e,2r,5r)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

24-CYCLOPROPYL-(1ALPHA,3BETA,5Z,7E,22E,24S)-9,10-SECOCHOLA-5,7,10(19),22-TETRAENE-1,3,24-TRIOL

Calcipotriene

Calcipotriene USP/EP/BP

Calcipotriene API

Carpotriol

112828-00-9

API