Paricalcitol
- Product Name
- Paricalcitol
- CAS No.
- 131918-61-1
- Chemical Name
- Paricalcitol
- Synonyms
- Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;19-nor-1alpha,25-dihydroxyvitamin D2
- CBNumber
- CB0500520
- Molecular Formula
- C27H44O3
- Formula Weight
- 416.65
- MOL File
- 131918-61-1.mol
Paricalcitol Property
- Boiling point:
- 564.8±50.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- Flash point:
- 14℃
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- pka
- 14.34±0.40(Predicted)
- InChIKey
- BPKAHTKRCLCHEA-UBFJEZKGSA-N
- SMILES
- C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r|
- CAS DataBase Reference
- 131918-61-1(CAS DataBase Reference)
Safety
- RIDADR
- UN1170 - class 3 - PG 2 - Ethanol, solution
- HS Code
- 2936299055
- Hazardous Substances Data
- 131918-61-1(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H330Fatal if inhaled
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- 1499414
- Product name
- Paricalcitol
- Packaging
- 3ml
- Price
- $904
- Updated
- 2024/03/01
- Product number
- 1499403
- Product name
- Paricalcitol
- Packaging
- 10mg
- Price
- $4260
- Updated
- 2024/03/01
- Product number
- 17716
- Product name
- Paricalcitol
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 17716
- Product name
- Paricalcitol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- 17716
- Product name
- Paricalcitol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $778
- Updated
- 2024/03/01
Paricalcitol Chemical Properties,Usage,Production
Description
Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
Description
Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Chemical Properties
White Solid
Originator
Abbott (US)
Uses
Antihyperparathyriod
Uses
1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Uses
Synthetic analog of vitamin D. Antihyperparathyroid.
Definition
ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.
brand name
Zemplar (Abbott).
Clinical Use
Vitamin D analogue:
Treatment and prevention of secondary
hyperparathyroidism associated with chronic renal
failure
Metabolism
Extensively metabolised via hepatic and non-hepatic
pathways to form two relatively inactive metabolites.
After oral administration of 3
H-paricalcitol, only about
2% of the dose was eliminated unchanged in the faeces,
and no parent drug found in the urine.
Approximately
70% of the radioactivity was eliminated in the faeces and
18% was recovered in the urine. Most of the systemic
exposure was from the parent drug.
Paricalcitol Preparation Products And Raw materials
Raw materials
Preparation Products
Paricalcitol Suppliers
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View Lastest Price from Paricalcitol manufacturers
- Product
- Paricalcitol 131918-61-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2021-03-22
- Product
- Paricalcitol 131918-61-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2024-04-03
- Product
- Paricalcitol 131918-61-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2022-10-18