Paricalcitol

ChemicalBook > CAS DataBase List > Paricalcitol

Product Name: Paricalcitol
CAS No.: 131918-61-1
Chemical Name: Paricalcitol
Synonyms: Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;19-nor-1alpha,25-dihydroxyvitamin D2
CBNumber: CB0500520
Molecular Formula: C27H44O3
Formula Weight: 416.65
MOL File: 131918-61-1.mol

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Paricalcitol Property

Boiling point:: 564.8±50.0 °C(Predicted)
Density: 1.121±0.06 g/cm3(Predicted)
Flash point:: 14℃
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka: 14.34±0.40(Predicted)
form: Solid
color: White to off-white
InChIKey: BPKAHTKRCLCHEA-UBFJEZKGSA-N
SMILES: C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r|
CAS DataBase Reference: 131918-61-1(CAS DataBase Reference)

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Safety

RIDADR: UN1170 - class 3 - PG 2 - Ethanol, solution
HS Code: 2936299055
Hazardous Substances Data: 131918-61-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H330Fatal if inhaled

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1499414
Product name: Paricalcitol
Packaging: 3ml
Price: $904
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1499403
Product name: Paricalcitol
Packaging: 10mg
Price: $4260
Updated: 2024/03/01

Cayman Chemical

Product number: 17716
Product name: Paricalcitol
Purity: ≥98%
Packaging: 500μg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 17716
Product name: Paricalcitol
Purity: ≥98%
Packaging: 1mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 17716
Product name: Paricalcitol
Purity: ≥98%
Packaging: 5mg
Price: $778
Updated: 2024/03/01

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Paricalcitol Chemical Properties,Usage,Production

Description

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.

Description

Paricalcitol is a synthetic 1,25-dihydroxy vitamin D₂ analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Chemical Properties

White Solid

Originator

Abbott (US)

Uses

Antihyperparathyriod

Uses

1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Uses

Synthetic analog of vitamin D. Antihyperparathyroid.

Definition

ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.

brand name

Zemplar (Abbott).

Clinical Use

Vitamin D analogue:
Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure

Metabolism

Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine.
Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug.

Paricalcitol Preparation Products And Raw materials

Raw materials

Preparation Products

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Paricalcitol Suppliers

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View Lastest Price from Paricalcitol manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Paricalcitol 131918-61-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.0%min. HPLC
Supply Ability: 10000
Release date: 2024-11-08

airuikechemical co., ltd.

Product: Paricalcitol 131918-61-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 20tons
Release date: 2024-04-03

ANHUI WITOP BIOTECH CO., LTD

Product: Paricalcitol 131918-61-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10 tons
Release date: 2021-03-22

131918-61-1, ParicalcitolRelated Search:

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CS-1390

PARICALCITOL (10 MG)F0E3030.997MG/MG(AI)

PARICALCITOL

19-nor-1alpha,25-dihydroxyvitamin D2

(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol

Zemplar

1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-

Paricalcitol, >=98%

1,25-DihydroxyvitaMin D2 Paricalcitol

Paricalcitol(Zemplar)

Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED)

(1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

(1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol

19-Nor-1,25- dihydroxyvitaMin D2

1α,25-Dihydroxy-19-nor-vitaMin D2

Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol

(1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)cyclohexane-1,3-diol

ParicalcitolQ: What is Paricalcitol Q: What is the CAS Number of Paricalcitol Q: What is the storage condition of Paricalcitol Q: What are the applications of Paricalcitol

Paricalcitol (COLD SHIPMENT REQUIRED) (1499403)

(1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol

Paricalciferol

Zemplarr

(1R,3R)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}cyclohexane-1,3-diol

131918-61-1

131919-61-1

Vitamin D3 analogs

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals

131918-61-1