ChemicalBook > CAS DataBase List > Dimethyl adipate

Dimethyl adipate

Product Name
Dimethyl adipate
CAS No.
627-93-0
Chemical Name
Dimethyl adipate
Synonyms
DIMETHYL HEXANEDIOATE;dbe-6;DIBASICESTERS;Adipic acid-di;Dimethyladipat;DIMETHYL ADIPATE;AKOS BBS-00004546;Flexisolv DBE-LVP;DBE 6 DIBASIC ESTER;Adipic acid dimethyl
CBNumber
CB1412954
Molecular Formula
C8H14O4
Formula Weight
174.19
MOL File
627-93-0.mol
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Dimethyl adipate Property

Melting point:
8 °C (lit.)
Boiling point:
109-110 °C/14 mmHg (lit.)
Density 
1.062 g/mL at 20 °C (lit.)
vapor pressure 
0.2 mm Hg ( 20 °C)
refractive index 
n20/D 1.428(lit.)
FEMA 
4472 | DIMETHYL ADIPATE
Flash point:
225 °F
storage temp. 
Store below +30°C.
solubility 
<1g/l
form 
Liquid
color 
Clear
Odor
at 100.00 %. mild nutty
Odor Type
nutty
explosive limit
0.81-8.1%(V)
Water Solubility 
Miscible with alcohols and ether. Immiscible with water.
Merck 
14,162
JECFA Number
1964
BRN 
1707443
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, acids, bases reducing agents.
InChIKey
UDSFAEKRVUSQDD-UHFFFAOYSA-N
LogP
1.4 at 22℃
CAS DataBase Reference
627-93-0(CAS DataBase Reference)
NIST Chemistry Reference
Hexanedioic acid, dimethyl ester(627-93-0)
EPA Substance Registry System
Dimethyl adipate (627-93-0)
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Safety

Safety Statements 
24/25
WGK Germany 
1
RTECS 
AV1645000
Autoignition Temperature
680 °F
TSCA 
Yes
HS Code 
29171290
Hazardous Substances Data
627-93-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 8191 mg/kg LD50 dermal Rabbit > 2250 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00097
Product name
Dimethyl adipate
Purity
for synthesis
Packaging
250ML
Price
$43.3
Updated
2025/07/31
Sigma-Aldrich
Product number
8.00097
Product name
Dimethyl adipate
Purity
for synthesis
Packaging
1L
Price
$127
Updated
2025/07/31
Sigma-Aldrich
Product number
186252
Product name
Dimethyl adipate
Purity
≥99%
Packaging
100g
Price
$44.93
Updated
2025/07/31
Sigma-Aldrich
Product number
186252
Product name
Dimethyl adipate
Purity
≥99%
Packaging
500g
Price
$114
Updated
2025/07/31
TCI Chemical
Product number
A0166
Product name
Dimethyl Adipate
Purity
>99.0%(GC)
Packaging
25mL
Price
$21
Updated
2025/07/31
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Dimethyl adipate Chemical Properties,Usage,Production

Description

Dimethyl adipate (DMA) is a colourless and flammable liquid. It is soluble in alcohol and ether but sparingly soluble in water. DMA is incompatible with strong oxidising agents, and on decomposition, it emits carbon monoxide, irritating and toxic fumes and gases, and carbon dioxide. DMA reacts with acids, alkalis, and strong oxidants. DMA is synthesised by the esterification of adipic acid. DMA is part of a dibasic ester (DBE) blend used as a major ingredient in several paint strippers, and the DBE blends used in paint stripping formulations contain a major portion (about 90%) of DMA. DMA is used as a chemical intermediate (polymers, agrochemicals), cellulose resins, a speciality solvent (inks, coatings, adhesives), and an emollient and can also be utilised as a paint remover and plasticiser.

Chemical Properties

Dimethyl adipate is a colorless liquid. It is a fatty acid methyl ester.

Uses

Dimethyl adipate is used in cosmetics (in emollients and skin conditioning).It is used as a plasticizer for cellulose-type resins and a finish remover.It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.

Uses

Dimethyl adipate is used in cosmetics (in emollients and skin conditioning). It acts as a cosmetic plasticizer. It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.

Definition

ChEBI: Dimethyl adipate is a fatty acid methyl ester.

Production Methods

Dimethyl adipate is manufactured via esterification of adipic acid and methanol in the presence of an acid catalyst.

General Description

Colorless liquid.

Air & Water Reactions

Flammable. Hydrolyzed by strong mineral acids and strong alkalis.

Reactivity Profile

Dimethyl adipate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Health Hazard

May be harmful by inhalation, ingestion, or skin absorption. May cause irritation.

Health Hazard

Exposures to dimethyl adipate cause toxicity and adverse health effects in laboratory animals and humans. Workplace exposures to dimethyl adipate by inhalation, ingestion, or skin absorption cause harmful and irritation effects to users.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

Dimethyl adipate was synthesized by immobilized Candida antarctica lipase B-catalyzed esterification of adipic acid and methanol.

According to the general procedure described above, Dimethyl adipate has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 9%.
1H NMR (400.1 MHz, CDCl3): δ = 3.56 (6H, s, H1-H10), 2.23 (4H, m, H4-H7), 1.56 (4H, m, H5-H6).
13C NMR (100.5 MHz, CDCl3): δ = 173.4 (C3-C8), 51.2 (C1-C10), 33.4 (C4-C7), 24.1 (C5-C6)
https://pubmed.ncbi.nlm.nih.gov/20632329/

Carcinogenicity

In a chronic inhalation toxicity study of dimethyl adipate, groups of male and female rats were exposed to 400 mg/m3 of dimethyl adipate over a 90-day period. Focal respiratory metaplasia of the olfactory epithelium was found. These nonneoplastic lesions were minimal to mild in severity .

Toxics Screening Level

The ITSL for Dimethyl Adipate is 1 μg/m3 based on annual averaging time.

Precautions

During handling of dimethyl adipate, occupational workers should be careful and use self-contained breathing apparatus, rubber boots, and heavy rubber gloves and avoid prolonged period of exposures. Workers should avoid contact of dimethyl adipate with skin, eyes and nose.

Dimethyl adipate Preparation Products And Raw materials

Raw materials

Adipic acid

Preparation Products

3-Ethyl-2-hydroxy-2-cyclopenten-1-one
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View Lastest Price from Dimethyl adipate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dimethyl adipate 627-93-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.96%
Supply Ability
1000kg
Release date
2025-07-09
Hebei Chuanghai Biotechnology Co., Ltd
Product
Dimethyl Adipate 627-93-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dimethyl Adipate 627-93-0
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-30

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