Silver acetate Property

Melting point:

decomposes [STR93]

Density 

3.25

storage temp. 

Store below +30°C.

solubility 

10.2g/l

form 

Powder/Solid

Specific Gravity

3.259

color 

White to gray

Water Solubility 

10.2 g/L (20 ºC)

Sensitive 

Light Sensitive

Hydrolytic Sensitivity

4: no reaction with water under neutral conditions

Merck 

14,8505

Solubility Product Constant (Ksp)

pKsp: 2.71

BRN 

3595636

Exposure limits

ACGIH: TWA 0.01 mg/m3
NIOSH: IDLH 10 mg/m3; TWA 0.01 mg/m3

Stability:

Stable, but light sensitive. Incompatible with strong reducing agents.

InChIKey

CQLFBEKRDQMJLZ-UHFFFAOYSA-M

CAS DataBase Reference

563-63-3(CAS DataBase Reference)

NIST Chemistry Reference

Silver acetate(563-63-3)

EPA Substance Registry System

Silver acetate (563-63-3)

Safety

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-50

Safety Statements 

26-36-37/39-61

RIDADR 

1759

WGK Germany 

3

RTECS 

AJ4100000

F 

8

TSCA 

Yes

HazardClass 

9

HS Code 

28432900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Silver acetate Chemical Properties,Usage,Production

Description

Silver acetate (C2H3AgO2) is a photosensitive, white, crystalline solid which is widely used in the laboratory. As a source of silver ions lacking an oxidizing anion, it is a useful reagent for direct ortho-arylation, and for conversion of organohalogen compounds into alcohols, etc. It also serves as a catalyst to effectively catalyze the cycloaddition reactions of isocyanoacetates with a variety of olefins. It can be employed in the novel preparation of highly reflective, conductive silvered polymer films.Besides, it has applications in some antismoking drugs and in the health field, in which the products containing silver acetate have been applied in spray, and lozenges to deter smokers from smoking. When mixed with smoke, the silver acetate creates an unpleasant metallic taste in the smoker's mouth, thereby preventing them from smoking.

References

https://en.wikipedia.org/wiki/Silver_acetate
https://www.alfa.com/zh-cn/catalog/011660/
http://www.sigmaaldrich.com/catalog/product/sigma/s1633?lang=en&region=US

Description

Silver acetate is an organic compound with the empirical formula CH₃COOAg (or AgC₂H₃O₂). It is a photosensitive, white crystalline solid. It is a useful reagent in the laboratory as a water soluble source of silver lacking an oxidizing anion. It has been used in some antismoking drugs.

Chemical Properties

Off-White/Brown Crystalline Powder

Uses

Oxidizing agent for use in liquid ammonia: Kline, Kershner, Inorg. Chem. 5, 932 (1966).

Uses

In the health field, silver acetate-containing products have been used in gum, spray, and lozenges to deter smokers from smoking. The silver in these products, when mixed with smoke, creates an unpleasant metallic taste in the smoker's mouth, thus deterring them from smoking. Lozenges containing 2.5 mg of silver acetate showed "modest efficacy" on 500 adult smokers tested over a three-month period. However, over a period of 12 months, prevention failed. In 1974, silver acetate was first introduced in Europe as an over-thecounter smoking-deterrent lozenge (Repaton) and then three years later as a chewing gum (Tabmint).

Uses

It is a reagent in the laboratory as a source of silver ions lacking an oxidizing anion. It is a reagent for direct ortho-arylation, and for conversion of organohalogen compounds into alcohols. Woodward cis-hydroxylation reaction employs silver acetate and iodine for selective conversin of alkenes into cis-diols. Silver acetate is the more preferred reagent for facile carbonylation of primary and secondary amines. It is also employed in the preparation of highly reflective, conductive silvered polymer films.

Reactions

3 – 1 - Carbonylation
Silver acetate, when combined with carbon monoxide (CO), can induce the carbonylation of primary and secondary amines. Other silver salts can be used but the acetate gives the best yield.
2 R₂NH + 2 AgOAc + CO → [R₂N]₂CO + 2 HOAc + 2 Ag
3 – 2 - Hydrogenation
Silver acetate in a solution of pyridine absorbs hydrogen and is reduced to metallic silver.
3 – 3 - Direct ortho - arylation
Silver acetate is a useful reagent for direct ortho-arylation (to install two adjacent substituents on an aromatic ring) for of benzylamines and N-methylbenzylamines. The reaction is palladiumcatalized and requires a slight excess of silver acetate.This reaction is shorter than previous ortho-arylation methods.

brand name

Smokerette;Tabmint.

World Health Organization (WHO)

Silver acetate has been used as a disinfectant and as an antismoking aid. It was refused registration in Cyprus on the grounds that prolonged use of silver salts can cause permanent argyria and that no well-controlled trials have been performed to establish the safety and efficacy of the preparation. It remains registered as an aid to stopping smoking in Canada and the United States.

General Description

White crystalline plates. Light sensitive. Density 3.26 g / cm3.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Silver acetate is freely soluble in dilute nitric acid [Merck]. Can serve as an oxidizing agent.

Hazard

Toxic material.

Health Hazard

Inhalation of dust irritates nose and throat. Contact with eyes or skin causes irritation. If continued for a long period, ingestion or inhalation of silver compounds can cause permanent discoloration of skin (argyria).

Safety

The LD₅₀ of silver acetate in mice is 36.7 mg/kg. Low doses of silver acetate in mice produced hyper-excitability, ataxia, central nervous system depression, labored breathing, and even death. The U.S. FDA recommends that silver acetate intake be limited to 756 mg over a short period of time; excessive intake may cause argyria.

Synthesis

The silver acetate salt can be synthesized by the reaction of acetic acid and silver carbonate at 45 – 60 °C. After allowing cooling to room temperature, the solid product precipitates.
2 CH₃CO₂H + Ag₂CO₃ → 2 AgO₂CCH₃ + H₂O + CO₂
It can also be precipitated from concentrated aqueous solutions of silver nitrate by treatment with a solution of sodium acetate.
The structure of silver acetate consists of 8-membered Ag₂O₄C₂ rings formed by a pair of acetate ligands bridging a pair of silver centres.

Purification Methods

Shake it with acetic acid for three days, and the process is repeated with fresh acid. The solid is then dried in a vacuum oven at 40o for 48hours. It has also been recrystallised from water containing a trace of acetic acid, and dried in air. Store it in the dark. [Beilstein 2 IV 112.]