ChemicalBook > CAS DataBase List > Amylamine

Amylamine

Product Name
Amylamine
CAS No.
110-58-7
Chemical Name
Amylamine
Synonyms
PENTYLAMINE;N-PENTYLAMINE;1-Pentanamine;Pentylamin;1-PENTYLAMINE;Amylamin;AMINE C5;AMYLAMINE;n-C5H11NH2;AMYLAMINES
CBNumber
CB1420771
Molecular Formula
C5H13N
Formula Weight
87.16
MOL File
110-58-7.mol
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Amylamine Property

Melting point:
−55 °C(lit.)
Boiling point:
104 °C(lit.)
Density 
0.752 g/mL at 25 °C(lit.)
vapor density 
3.01 (vs air)
vapor pressure 
120.9 hPa (47 °C)
FEMA 
4242 | PENTYLAMINE
refractive index 
n20/D 1.411(lit.)
Flash point:
42 °F
storage temp. 
Flammables area
solubility 
Soluble in alcohol, ether.
pka
10.63(at 25℃)
form 
Liquid
color 
Clear colorless to very slightly yellow
Odor
at 0.10 % in propylene glycol. ammoniacal fishy
Odor Type
fishy
explosive limit
2.2-22%(V)
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,598
JECFA Number
1585
BRN 
505953
Dielectric constant
4.6（22℃）
LogP
1.49
CAS DataBase Reference
110-58-7(CAS DataBase Reference)
NIST Chemistry Reference
1-Pentanamine(110-58-7)
EPA Substance Registry System
Amylamine (110-58-7)
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Safety

Hazard Codes 
F,C
Risk Statements 
11-22-34-42/43-20/21/22-52/53
Safety Statements 
16-26-36/37/39-45-33-61
RIDADR 
UN 1106 3/PG 2
WGK Germany 
3
RTECS 
SC0300000
F 
34
Autoignition Temperature
305 °C
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29211990
Toxicity
LD50 orally in Rabbit: 470 mg/kg LD50 dermal Rabbit 1120 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
171409
Product name
Amylamine
Purity
99%
Packaging
25ml
Price
$60
Updated
2024/03/01
Sigma-Aldrich
Product number
171409
Product name
Amylamine
Purity
99%
Packaging
50ml
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
A0445
Product name
Amylamine
Purity
>98.0%(GC)
Packaging
25mL
Price
$41
Updated
2024/03/01
TCI Chemical
Product number
A0445
Product name
Amylamine
Purity
>98.0%(GC)
Packaging
100mL
Price
$124
Updated
2024/03/01
Alfa Aesar
Product number
A11674
Product name
1-Pentylamine, 98%
Packaging
25g
Price
$45.65
Updated
2024/03/01
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Amylamine Chemical Properties,Usage,Production

Chemical Properties

clear colourless to very slightly yellow liquid

Chemical Properties

n-Amylamine is a strong base in aqueous solutions and organic solvents that readily forms salts with acids.

Chemical Properties

Colorless to yellow liquid; fishy aroma.

Uses

1-Pentylamine is a useful reactant in organic synthesis.

Uses

Amylamine is a general reagent used in functionalizing the target molecules with pentyl chain. It has also been used as a cosurfactant to increase the phase stability of the bilayer systems.

Uses

Chemical intermediate, dyestuffs, rubber chemicals, insecticides, synthetic detergents, flotation agents, corrosion inhibitors, solvent, gasoline additive, pharmaceuticals.

Production Methods

n-Amylamine is primarily produced by the amination of alkyl halides rather than using alcohol. This reaction is carried out at a temperature of 300-500°C and a pressure of 790-3550 kPa. Alternatively, n-amylamine can be produced from the reaction of amyl chlorides with ammonia. This procedure also produces small amounts of amylenes and amyl alcohol which can be removed by steam distillation (Schweizer et al 1978).

Definition

ChEBI: Pentan-1-amine is a primary aliphatic amine that is n-pentane in which a hydrogen of one of the methyl groups is replaced by an amino group. A water-soluble liquid with boiling point 104℃, it is a strong irritant.

Aroma threshold values

High strength odor; fishy type; recommend smelling in a 0.10% solution or less.

General Description

A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Irritates the eyes and respiratory system. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a corrosion inhibitor, solvent, flotation agent and in the manufacture of other chemicals.

Air & Water Reactions

Highly flammable. Less dense than water and soluble in water.

Reactivity Profile

AMYLAMINES are amines. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Can react with oxidizing materials. [NTP 1992].

Hazard

Flammable, dangerous fire risk. Strong irritant.

Health Hazard

Direct skin contact with amylamine leads to first- and second-degree burns. Inhalation results in irritation of the mucous membranes of the nose and respiratory tract. It has been reported that in humans a concentration of 0.3 mg/1 of the inhaled n-amylamine had no irritating effect (Loit and Filou 1964).

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Industrial uses

In 1976, 800 tons of n-amylamine was produced for a variety of commercial purposes. It is used in textiles, lubrication and in the manufacture of dyestuffs, emulsifying agents, anti-oxidants and desizing agents for the textile and pharmaceutical industry. It is also valuable as a corrosion inhibitor and as a base for emulsifiers which are soluble in vegetable and mineral oils.

Safety Profile

Poison by intraperitoneal route. A corrosive. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx.

Metabolism

As exposure to n-amylamine is often via inhalation, several studies have investigated the uptake and distribution of amylamine by lungs. For a number of aliphatic amines their uptake correlated well with their partition coefficients (between n-octanol and pH 7 buffer) (Fowler et al 1976). The amino group, as well as the relatively lipophilic alkyl group, was required for lung specificity. It was also demonstrated using inhibitors that n-amylamine was rapidly metabolized to CO2 by monoamine oxidase and that CO2 exhalation increased with increasing chain length from C4 to C13. Another study on the pharmacokinetics of n-amylamine uptake by lung demonstrated that the distribution of n-amylamine between vascular and extravascular spaces was sensitive to arterial pH, with alkalosis favoring extravascular distribution (Effros and Chihard 1969).
The ability of n-amylamine to serve as a substrate or an inhibitor of monoamine oxidase has been addressed in a number of in vitro and in vivo studies. However, many of the results are contradictory and appear to be related to concentrationdependent phenomena. When tested in vitro, n-amylamine was reported to inhibit rat liver monoamine oxidase in a partially irreversible and noncompetitive manner (Takagi and Gomi 1966). Longer chain aliphatic amines were even more inhibitory. In contrast, at lower concentrations n-amylamine served as a substrate for monoamine oxidase. Weiner (1966) also concluded that n-amylamine was a poor substrate for monoamine oxidase isolated from rat, mouse, dog, cat, and human brains. The amine was more active towards rabbit brain monoamine oxidase. When administered intraperitoneally to rats, n-amylamine had no effect on liver monoamine oxidase activity (Valiev 1974).
Several other studies strongly suggest that amylamine is a substrate for monoamine oxidase and is metabolized by this enzyme in vivo. McEwen (1965a) purified monoamine oxidase from human plasma and found it to be most active against several simple aliphatic amines, with butylamine being the most active substrate. Further characterization indicated that high concentrations of the amine inhibited the enzyme and that the non-ionized forms of the amines are responsible for the observed competitive inhibition (McEwen 1965b). In agreement, others reported that n-amylamine was a good substrate for monoamine oxidase purified from dog serum (Ikeno et al 1978). In another in vitro study, Kurosawa (1974) demonstrated n-amylamine to be a substrate for monoamine oxidase prepared from beef or rat liver. In vivo, it was found that, in rats, the release of 14CO2 from 14C-amylamine was significantly decreased by riboflavin or iron deficiency, conditions which also decreased monoamine oxidase activity (Sourkes and Missala 1976). These studies all indicate that amylamine is metabolized by monoamine oxidase in a variety of species.

Purification Methods

Dry it by prolonged shaking with NaOH pellets, then distilling. Store it in a CO2-free atmosphere. [Beilstein 4 IV 674.]

Amylamine Preparation Products And Raw materials

Raw materials

Sodium azide Hexanoic acid

Preparation Products

Pentyl isocyanate TETRAPENTYLAMMONIUM BROMIDE
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Amylamine Suppliers

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View Lastest Price from Amylamine manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
n-Amylamine 110-58-7
Price
US $0.00/kg
Min. Order
200kg
Purity
99%
Supply Ability
20 tons
Release date
2024-09-08
Hebei Weibang Biotechnology Co., Ltd
Product
Amylamine 110-58-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2023-01-11
Hebei Mojin Biotechnology Co., Ltd
Product
Amylamine 110-58-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-15

110-58-7, AmylamineRelated Search:

2-Amino-5-diethylaminopentane 2,4-DIBROMOPENTANE Pentane 2-Methylbutane Methylcyclopentane 2,2-DIMETHYLPROPANE Bromocyclopentane Cyclopentane Sodium pentanesulfonate N-OCTANE Valeronitrile Valeric acid 1-Pentanol Valeraldehyde PENTYL VALERATE PENTYL ETHER 1-Pentene 1-PENTANESULFONIC ACID SODIUM SALT MONOHYDRATE

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