ChemicalBook > CAS DataBase List > 1-N-Cbz-3-pyrrolidinone

1-N-Cbz-3-pyrrolidinone

Product Name
1-N-Cbz-3-pyrrolidinone
CAS No.
130312-02-6
Chemical Name
1-N-Cbz-3-pyrrolidinone
Synonyms
1-Z-3-PYRROLIDINONE;N-CBZ-3-PYRROLIDINONE;1-CBZ-3-PYRROLIDINONE;1-N-CBZ-3-PYRROLIDINONE;1-Z-3-Pyrrolidinone 96%;1-CBZ-3-ketopyrrolidine;1-Carbobenzoxy-3-pyrrolidone;1-N-CBZ-3-PYRROLIDINONE, 90+%;1-Carbobenzyloxy-3-pyrrolidone;1-Carbobenzoxy-3-pyrrolidinone
CBNumber
CB1432521
Molecular Formula
C12H13NO3
Formula Weight
219.24
MOL File
130312-02-6.mol
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1-N-Cbz-3-pyrrolidinone Property

Melting point:
45-47°C
Boiling point:
370.2±42.0 °C(Predicted)
Density 
1.1897 g/mL at 25 °C
refractive index 
n20/D 1.5410
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-1.84±0.20(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C12H13NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5H,6-9H2
InChIKey
LMHWEUQNJRXMCD-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC(=O)C1
CAS DataBase Reference
130312-02-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-40
Safety Statements 
23-24/25-36/37
WGK Germany 
2
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
661201
Product name
1-Z-3-Pyrrolidinone
Purity
96%
Packaging
5g
Price
$71.49
Updated
2025/07/31
Sigma-Aldrich
Product number
661201
Product name
1-Z-3-Pyrrolidinone
Purity
96%
Packaging
1g
Price
$42.4
Updated
2023/06/20
TCI Chemical
Product number
C2437
Product name
1-Carbobenzoxy-3-pyrrolidone
Purity
>98.0%(GC)
Packaging
1g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
C2437
Product name
1-Carbobenzoxy-3-pyrrolidone
Purity
>98.0%(GC)
Packaging
5g
Price
$158
Updated
2025/07/31
Apolloscientific
Product number
OR61344
Product name
Pyrrolidin-3-one,N-CBZprotected
Purity
97%
Packaging
25g
Price
$124
Updated
2021/12/16
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1-N-Cbz-3-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Synthesis

95656-88-5

130312-02-6

General procedure for the synthesis of N-Cbz-3-pyrrolidinone from N-CBZ-3-hydroxypyrrolidine: intermediate 6.iii (1.10 g) was dissolved in dichloromethane (DCM, 8 mL) and cooled to 0 °C. Under stirring, N,N-diisopropylethylamine (DIPEA, 2.5 mL) was added slowly and dropwise, followed by a solution of sulfur trioxide pyridine complex (1.79 g) in dimethyl sulfoxide (DMSO, 6.5 mL). The reaction mixture was stirred continuously at 0 °C for 1 h, after which the reaction was quenched by the addition of water (6 mL). The aqueous phase was extracted with a solvent mixture of ether/hexane (1:1, 3 × 5 mL) and the organic phases were combined. After the organic phase was concentrated under vacuum, the residue obtained was solubilized with a solvent mixture of ether/hexane (1:1) and purified by silica gel column chromatography (n-hexane/ethyl acetate, 5:5) to give 1.05 g (96% yield) of the light yellow oily product N-Cbz-3-pyrrolidinone. The product was characterized by 1H NMR (DMSO-d6; δ ppm): 2.48-2.61 (2H, m); 3.61-3.80 (4H, m); 5.09 (2H, s); 7.27-7.41 (5H, m).

References

[1] Patent: US2009/247578, 2009, A1. Location in patent: Page/Page column 14
[2] Patent: WO2008/56335, 2008, A1. Location in patent: Page/Page column 34
[3] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 51; 52
[4] Chemical Communications, 2007, # 21, p. 2136 - 2138
[5] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 581

1-N-Cbz-3-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-N-Cbz-3-pyrrolidinone Suppliers

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View Lastest Price from 1-N-Cbz-3-pyrrolidinone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
1-N-Cbz-3-pyrrolidinone 130312-02-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100000kgs
Release date
2024-08-23
Shaanxi Dideu Medichem Co. Ltd
Product
1-N-Cbz-3-pyrrolidinone 130312-02-6
Price
US $998.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1T
Release date
2020-07-06
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-N-Cbz-3-pyrrolidinone 130312-02-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

130312-02-6, 1-N-Cbz-3-pyrrolidinoneRelated Search:

N-Vinyl-2-pyrrolidone 2-Pyrrolidinone Pyrrolidine 3-Pyrrolidinone Polyvinylpyrrolidone Crospovidone N-Methyl-2-pyrrolidone Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate METHYL-2-PYRROLIDONE 4,4-PENTAMETHYLENE-2-PYRROLIDINONE 1-CBZ-3-PYRROLIDINONE,N-CBZ-3-PYRROLIDINONE 4,4-PENTAMETHYLENE-2-PYRROLIDINONE 4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE 4-PHENYL-2-PYRROLIDINONE Pyrrole 2-Pyrrolidineacetic acid, 3-oxo-1-[(phenylmethoxy)carbonyl]-, ethyl ester N-CBZ-4-OXO-D-PROLINE N-CBZ-2-AZABICYCLO[2.2.1]HEPTAN-7-ONE

  • N-CBZ-3-PYRROLIDINONE
  • N-BENZYLOXYCARBONYL-3-PYRROLIDINONE
  • 3-OXO-1-PYRROLIDINECARBOXYLIC ACID, PHENYLMETHYL ESTER
  • 3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
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  • 1-N-CBZ-3-PYRROLIDINONE
  • 1-CBZ-3-PYRROLIDINONE
  • 1-CARBOBENZYLOXY-3-PYRROLIDINONE
  • BENZYL 3-OXOPYRROLIDINE-1-CARBOXYLATE
  • 1-BENZYLOXYCARBONYL-3-PIPERIDINONE
  • Pyrrolidin-3-one, N-CBZ protected 97%
  • 1-N-CBZ-3-PYRROLIDINONE, 90+%
  • 1-Cbz-3-pyrrolidinone 1-Carbobenzoxy-3-pyrrolidinone 1-Cbz-3-pyrrolidone
  • 1-Benzyloxycarbonyl-3-pyrrolidinone
  • 1-Carbobenzoxy-3-pyrrolidone
  • Benzyl 3-oxopyrrolidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-3-oxopyrrolidine
  • Pyrrolidin-3-one, N-CBZ protected
  • 1-Carbobenzyloxy-3-pyrrolidinone, 1-Cbz-3-pyrrolidinone, 3-Oxo-1-pyrrolidinecarboxylic acid, phenylmethyl ester, 3-Oxopyrrolidine-1-carboxylic acid benzyl ester, N-Benzyloxycarbonyl-3-pyrrolidinone
  • 1-Benzyloxycarbonylpyrrolidin-3-one
  • 1-Pyrrolidinecarboxylic acid, 3-oxo-, phenylmethyl ester
  • 1-Z-3-Pyrrolidinone 96%
  • 1-CBZ-3-ketopyrrolidine
  • 1-Carbobenzyloxy-3-pyrrolidone
  • 1-Carbobenzoxy-3-pyrrolidone &gt
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  • 130312-02-6
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  • Chemical Synthesis
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