1-N-Cbz-3-pyrrolidinone
- Product Name
- 1-N-Cbz-3-pyrrolidinone
- CAS No.
- 130312-02-6
- Chemical Name
- 1-N-Cbz-3-pyrrolidinone
- Synonyms
- 1-Z-3-PYRROLIDINONE;N-CBZ-3-PYRROLIDINONE;1-CBZ-3-PYRROLIDINONE;1-N-CBZ-3-PYRROLIDINONE;1-Z-3-Pyrrolidinone 96%;1-CBZ-3-ketopyrrolidine;1-Carbobenzoxy-3-pyrrolidone;1-N-CBZ-3-PYRROLIDINONE, 90+%;1-Carbobenzyloxy-3-pyrrolidone;1-Carbobenzoxy-3-pyrrolidinone
- CBNumber
- CB1432521
- Molecular Formula
- C12H13NO3
- Formula Weight
- 219.24
- MOL File
- 130312-02-6.mol
1-N-Cbz-3-pyrrolidinone Property
- Melting point:
- 45-47°C
- Boiling point:
- 370.2±42.0 °C(Predicted)
- Density
- 1.1897 g/mL at 25 °C
- refractive index
- n20/D 1.5410
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -1.84±0.20(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C12H13NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5H,6-9H2
- InChIKey
- LMHWEUQNJRXMCD-UHFFFAOYSA-N
- SMILES
- N1(C(OCC2=CC=CC=C2)=O)CCC(=O)C1
- CAS DataBase Reference
- 130312-02-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-40
- Safety Statements
- 23-24/25-36/37
- WGK Germany
- 2
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 661201
- Product name
- 1-Z-3-Pyrrolidinone
- Purity
- 96%
- Packaging
- 5g
- Price
- $71.49
- Updated
- 2025/07/31
- Product number
- 661201
- Product name
- 1-Z-3-Pyrrolidinone
- Purity
- 96%
- Packaging
- 1g
- Price
- $42.4
- Updated
- 2023/06/20
- Product number
- C2437
- Product name
- 1-Carbobenzoxy-3-pyrrolidone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- C2437
- Product name
- 1-Carbobenzoxy-3-pyrrolidone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $158
- Updated
- 2025/07/31
- Product number
- OR61344
- Product name
- Pyrrolidin-3-one,N-CBZprotected
- Purity
- 97%
- Packaging
- 25g
- Price
- $124
- Updated
- 2021/12/16
1-N-Cbz-3-pyrrolidinone Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Synthesis
95656-88-5
130312-02-6
General procedure for the synthesis of N-Cbz-3-pyrrolidinone from N-CBZ-3-hydroxypyrrolidine: intermediate 6.iii (1.10 g) was dissolved in dichloromethane (DCM, 8 mL) and cooled to 0 °C. Under stirring, N,N-diisopropylethylamine (DIPEA, 2.5 mL) was added slowly and dropwise, followed by a solution of sulfur trioxide pyridine complex (1.79 g) in dimethyl sulfoxide (DMSO, 6.5 mL). The reaction mixture was stirred continuously at 0 °C for 1 h, after which the reaction was quenched by the addition of water (6 mL). The aqueous phase was extracted with a solvent mixture of ether/hexane (1:1, 3 × 5 mL) and the organic phases were combined. After the organic phase was concentrated under vacuum, the residue obtained was solubilized with a solvent mixture of ether/hexane (1:1) and purified by silica gel column chromatography (n-hexane/ethyl acetate, 5:5) to give 1.05 g (96% yield) of the light yellow oily product N-Cbz-3-pyrrolidinone. The product was characterized by 1H NMR (DMSO-d6; δ ppm): 2.48-2.61 (2H, m); 3.61-3.80 (4H, m); 5.09 (2H, s); 7.27-7.41 (5H, m).
References
[1] Patent: US2009/247578, 2009, A1. Location in patent: Page/Page column 14
[2] Patent: WO2008/56335, 2008, A1. Location in patent: Page/Page column 34
[3] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 51; 52
[4] Chemical Communications, 2007, # 21, p. 2136 - 2138
[5] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 581
1-N-Cbz-3-pyrrolidinone Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Cbz-3-pyrrolidinone Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 1-N-Cbz-3-pyrrolidinone manufacturers
- Product
- 1-N-Cbz-3-pyrrolidinone 130312-02-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100000kgs
- Release date
- 2024-08-23
- Product
- 1-N-Cbz-3-pyrrolidinone 130312-02-6
- Price
- US $998.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1T
- Release date
- 2020-07-06
- Product
- 1-N-Cbz-3-pyrrolidinone 130312-02-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10