ICILIN
- Product Name
- ICILIN
- CAS No.
- 36945-98-9
- Chemical Name
- ICILIN
- Synonyms
- ICILIN;AG-3-5;Iciline;CS-1406;Icilin, >=98%;Icidin Ag-3-5;Icilin(AG 3-5);AG 3-5; AG-3-5;Icilin,AG-3-5, >96%;3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1h)-pyrimidinon
- CBNumber
- CB1439247
- Molecular Formula
- C16H13N3O4
- Formula Weight
- 311.29
- MOL File
- 36945-98-9.mol
ICILIN Property
- Boiling point:
- 594.8±50.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: 15 mg/mL, soluble
- form
- solid
- pka
- 9.94±0.35(Predicted)
- color
- yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- I9532
- Product name
- Icilin
- Purity
- ≥97% (HPLC), solid
- Packaging
- 10MG
- Price
- $168
- Updated
- 2023/06/20
- Product number
- I9532
- Product name
- Icilin
- Purity
- ≥97% (HPLC), solid
- Packaging
- 50MG
- Price
- $755
- Updated
- 2023/06/20
- Product number
- J67451
- Product name
- Icilin, 97%
- Packaging
- 10mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 10137
- Product name
- Icilin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 10137
- Product name
- Icilin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2024/03/01
ICILIN Chemical Properties,Usage,Production
Description
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50?= 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50?= 0.2 μM)2?and ANKTM1(TRPA1)3. Activator effects require Ca2+?and are pH dependent.2,4?Icilin induced G1?arrest in PC-3 prostate cancer cells without cell death.5
Uses
Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.
Definition
ChEBI: 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one is a C-nitro compound.
General Description
Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).
Biological Activity
Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK-293 cells (EC 50 = 0.36 μ M) more potently than menthol or low temperatures. Produces "wet shakes" in vivo .
Biochem/physiol Actions
Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.
storage
Room temperature
References
1) McKemy?et al. (2002)?Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature,?416?52 2) Andersson?et al. (2004)?TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci.,?24?5364 3) Story?et al. (2003)?ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell,?112?819 4) Chuang?et al. (2004)?The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron,?43?859 5) Kim?et al. (2011)?Icilin induces G1?arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun.,?406?30
ICILIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ICILIN manufacturers
- Product
- Icilin 36945-98-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Icilin 36945-98-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- ICILIN 36945-98-9
- Price
- US $230.00/G
- Min. Order
- 10KG
- Purity
- 98%
- Supply Ability
- 1kg
- Release date
- 2018-07-23