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Niguldipine (hydrochloride)

Product Name
Niguldipine (hydrochloride)
CAS No.
119934-51-9
Chemical Name
Niguldipine (hydrochloride)
Synonyms
Niguldipine HCl;Niguldipine Hydrochloride DISCONTINUED PLEASE SEE N598530
CBNumber
CB33152701
Molecular Formula
C36H40ClN3O6
Formula Weight
646.18
MOL File
119934-51-9.mol
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Niguldipine (hydrochloride) Property

storage temp. 
RT
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 25 mg/ml).
form 
Yellow crystalline solid.
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19534
Product name
Niguldipine (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19534
Product name
Niguldipine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
19534
Product name
Niguldipine (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$161
Updated
2024/03/01
TRC
Product number
N598530
Product name
NiguldipineHydrochloride
Packaging
1mg
Price
$40
Updated
2021/12/16
AK Scientific
Product number
1183CC
Product name
Niguldipinehydrochloride,(+/-)-
Packaging
10mg
Price
$190
Updated
2021/12/16
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Niguldipine (hydrochloride) Chemical Properties,Usage,Production

Description

Niguldipine HCl (119934-51-9) is an L-type calcium channel blocker (IC50 = 75 nM), which can also inhibit T-type calcium channels at higher concentrations (IC50 = 244 nM). Novel inhibitor of drug transport by p-glycoprotein.

Uses

Niguldipine Hydrochloride is a selective α 1-adrenoceptor antagonist. Also, it is a new calcium antagonist.

in vitro

niguldipine significantly increased the rate of long-lived protein degradation in human glioblastoma h4 cell, which indicated that niguldipine triggered autophagic degradation without inducing obvious cellular damage. also, niguldipine blocked intracellular ca2+ currents [1].

in vivo

female albino swiss mice were administered intraperitoneally in a volume of 10 ml/kg niguldipine for 30 min. niguldipine did not affect the electroconvulsive threshold in mice. compared to the anticonvulsive activity of niguldipine against electroconvulsions, niguldipine remarkably impaired the protective action of both phenobarbital and carbamazepine [2].

IC 50

s = 0.4 μm: inhibits l-type ca2+ channels

References

1) Stengel et al. (1998), Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells; Eur. J. Pharmacol., 342 339 2) Hollt et al. (1992), Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein; Biochem. Pharmacol., 43 2601

Niguldipine (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Niguldipine (hydrochloride) Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58