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IBERIOTOXIN

Product Name
IBERIOTOXIN
CAS No.
129203-60-7
Chemical Name
IBERIOTOXIN
Synonyms
IBTX;RLBTX;IBERIOTOXIN;IBERIOTOXIN 98%;Iberiotoxin Standard;IBERIOTOXIN USP/EP/BP;IBERIOTOXIN, RECOMBINANT;IBERIOTOXIN, BUTHUS TAMULUS;129203-60-7/182897-30-9（TFA);IBTX (SCORPION, BUTHUS TAMULUS)
CBNumber
CB8130448
Molecular Formula
C179H274N50O55S7
Formula Weight
4230.84786
MOL File
129203-60-7.mol
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IBERIOTOXIN Property

storage temp. 
-20°C
solubility 
H2O: 1 mg/mL, clear, colorless
form 
Salt-free lyophilized solid
Water Solubility 
Soluble to 0.70 mg/ml in water
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
28-36/37-45
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
NH6107500
F 
3-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
401002
Product name
Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem
Packaging
10μg
Price
$265
Updated
2024/03/01
Sigma-Aldrich
Product number
I5904
Product name
Iberiotoxin, recombinant from Mesobuthus tamulus
Purity
≥98% (HPLC), recombinant, expressed in E. coli
Packaging
5μG
Price
$108
Updated
2023/06/20
Sigma-Aldrich
Product number
I5904
Product name
Iberiotoxin, recombinant from Mesobuthus tamulus
Purity
≥98% (HPLC), recombinant, expressed in E. coli
Packaging
10μG
Price
$184
Updated
2023/06/20
Sigma-Aldrich
Product number
I5904
Product name
Iberiotoxin, recombinant from Mesobuthus tamulus
Purity
≥98% (HPLC), recombinant, expressed in E. coli
Packaging
100μG
Price
$541
Updated
2023/06/20
Tocris
Product number
1086
Product name
Iberiotoxin
Packaging
100U
Price
$333
Updated
2021/12/16
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IBERIOTOXIN Chemical Properties,Usage,Production

Uses

Iberiotoxin is a selective and reversible inhibitor of high-conductance calcium-activated potassium channel. A toxin purified from the Eastern Indian red scorpion Buthus tamulus.

Uses

Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K+ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca2+- activated K+ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.

Uses

Selective probe for high-conductance calcium-activated potassium channels.

Biological Activity

iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion mesobuthus tamulus and was shown to selectively block large conductance ca2+-activated k+ channels(bkca) in smooth muscle cells.in single channel recordings, iberiotoxin can reversibly block outward currents mediated by bkca in excised membrane patches from bovine aortic smooth muscle with an ic50 value of 250 pm. it is also a noncompetitive, partial inhibitor of charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (ki = 250 pm).[1]. galvez a, gimenez-gallego g, reuben j p, et al. purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion buthus tamulus. the journal of biological chemisty, 1990, 265(19): 11083-11090.

Biochem/physiol Actions

The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.

storage

-20°C (desiccate)

IBERIOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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IBERIOTOXIN Suppliers

China 55 Europe 1 France 1 Germany 3 Japan 1 Switzerland 3 United Kingdom 3 United States 12 Global 79
Hefei KS-V Peptide Biotechnology Co., Ltd.
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0551-65120828 17368858770
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021-54306202 13764082696;
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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129203-60-7, IBERIOTOXINRelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide PHENYLSELENOL METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) COBALT(II) ACETYLACETONATE Cupric acetylacetonate Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate N-BUTYLISOCYANIDE Ethyl isocyanoacetate SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE

  • IBTX
  • IBTX (SCORPION, BUTHUS TAMULUS)
  • IBERIOTOXIN
  • IBERIOTOXIN, BUTHUS TAMULUS
  • IBERIOTOXIN SCORPION BUTHUS TAMULUS
  • PGLU-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN [DISULFIDE BRIDGES: 7-28, 13-3, 17-3]
  • RLBTX
  • PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
  • PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)
  • PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN
  • Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem
  • iberiotoxin from buthus tamulus
  • IBERIOTOXIN FROM BUTHUS TAMULUS, 50 UG*
  • IBERIOTOXIN, RECOMBINANT
  • IBERIOTOXIN 98%
  • PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH
  • PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH (DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)
  • M.W. 4230.91 C179H274N50O55S7
  • pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH
  • Iberiotoxin, recombinant from Mesobuthus tamulus
  • IBERIOTOXIN USP/EP/BP
  • Iberiotoxin Standard
  • 129203-60-7/182897-30-9（TFA)
  • 129203-60-7
  • C179H274N50O55S7
  • C179H273N49O56S7
  • Voltage-gated Ion Channels
  • Potassium Channel Modulators
  • Other
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Monovalent Ion Channels
  • Ion Channels
  • BioChemical
  • Biochemicals and Reagents
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Other
  • Potassium channel
  • Ion Channel Modulating Peptides
  • Potassium Channel ModulatorsPeptides for Cell Biology
  • Monovalent Ion Channels
  • Potassium Channel ModulatorsCell Signaling and Neuroscience
  • Scorpion
  • Toxins and Venoms
  • Voltage-gated Ion Channels