IBERIOTOXIN

ChemicalBook > CAS DataBase List > IBERIOTOXIN

Product Name: IBERIOTOXIN
CAS No.: 129203-60-7
Chemical Name: IBERIOTOXIN
Synonyms: IBTX;RLBTX;IBERIOTOXIN;IBERIOTOXIN 98%;Iberiotoxin Standard;IBERIOTOXIN USP/EP/BP;IBERIOTOXIN, RECOMBINANT;IBERIOTOXIN, BUTHUS TAMULUS;129203-60-7/182897-30-9（TFA);IBTX (SCORPION, BUTHUS TAMULUS)
CBNumber: CB8130448
Molecular Formula: C179H274N50O55S7
Formula Weight: 4230.84786
MOL File: 129203-60-7.mol

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IBERIOTOXIN Property

storage temp.: -20°C
solubility: H₂O: 1 mg/mL, clear, colorless
form: Salt-free lyophilized solid
Water Solubility: Soluble to 0.70 mg/ml in water

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 28-36/37-45
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: NH6107500
F: 3-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 401002
Product name: Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem
Packaging: 10μg
Price: $265
Updated: 2024/03/01

Sigma-Aldrich

Product number: I5904
Product name: Iberiotoxin, recombinant from Mesobuthus tamulus
Purity: ≥98% (HPLC), recombinant, expressed in E. coli
Packaging: 5μG
Price: $108
Updated: 2023/06/20

Sigma-Aldrich

Product number: I5904
Product name: Iberiotoxin, recombinant from Mesobuthus tamulus
Purity: ≥98% (HPLC), recombinant, expressed in E. coli
Packaging: 10μG
Price: $184
Updated: 2023/06/20

Sigma-Aldrich

Product number: I5904
Product name: Iberiotoxin, recombinant from Mesobuthus tamulus
Purity: ≥98% (HPLC), recombinant, expressed in E. coli
Packaging: 100μG
Price: $541
Updated: 2023/06/20

Tocris

Product number: 1086
Product name: Iberiotoxin
Packaging: 100U
Price: $333
Updated: 2021/12/16

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IBERIOTOXIN Chemical Properties,Usage,Production

Uses

Iberiotoxin is a selective and reversible inhibitor of high-conductance calcium-activated potassium channel. A toxin purified from the Eastern Indian red scorpion Buthus tamulus.

Uses

Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K⁺ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca²⁺- activated K⁺ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.

Uses

Selective probe for high-conductance calcium-activated potassium channels.

Biological Activity

iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion mesobuthus tamulus and was shown to selectively block large conductance ca2+-activated k+ channels(bkca) in smooth muscle cells.in single channel recordings, iberiotoxin can reversibly block outward currents mediated by bkca in excised membrane patches from bovine aortic smooth muscle with an ic50 value of 250 pm. it is also a noncompetitive, partial inhibitor of charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (ki = 250 pm).[1]. galvez a, gimenez-gallego g, reuben j p, et al. purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion buthus tamulus. the journal of biological chemisty, 1990, 265(19): 11083-11090.

Biochem/physiol Actions

The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.

storage

-20°C (desiccate)

IBERIOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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129203-60-7, IBERIOTOXINRelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide PHENYLSELENOL METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) COBALT(II) ACETYLACETONATE Cupric acetylacetonate Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate N-BUTYLISOCYANIDE Ethyl isocyanoacetate SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE

IBTX

IBTX (SCORPION, BUTHUS TAMULUS)

IBERIOTOXIN

IBERIOTOXIN, BUTHUS TAMULUS

IBERIOTOXIN SCORPION BUTHUS TAMULUS

PGLU-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN [DISULFIDE BRIDGES: 7-28, 13-3, 17-3]

RLBTX

PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ

PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)

PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN

Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem

iberiotoxin from buthus tamulus

IBERIOTOXIN FROM BUTHUS TAMULUS, 50 UG*

IBERIOTOXIN, RECOMBINANT

IBERIOTOXIN 98%

PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH

PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH (DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)

M.W. 4230.91 C179H274N50O55S7

pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH

Iberiotoxin, recombinant from Mesobuthus tamulus

IBERIOTOXIN USP/EP/BP

Iberiotoxin Standard

129203-60-7/182897-30-9（TFA)

129203-60-7

C179H274N50O55S7

C179H273N49O56S7

Voltage-gated Ion Channels

Potassium Channel Modulators

Other

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Type

Monovalent Ion Channels

Ion Channels

BioChemical

Biochemicals and Reagents

Cell Biology

Cell Signaling and Neuroscience

Enzyme Inhibitors

Enzyme Inhibitors by Type

Other

Potassium channel

Ion Channel Modulating Peptides

Potassium Channel ModulatorsPeptides for Cell Biology

Monovalent Ion Channels

Potassium Channel ModulatorsCell Signaling and Neuroscience

Scorpion

Toxins and Venoms

Voltage-gated Ion Channels