ChemicalBook > CAS DataBase List > IBERIOTOXIN

IBERIOTOXIN

Product Name
IBERIOTOXIN
CAS No.
129203-60-7
Chemical Name
IBERIOTOXIN
Synonyms
IBTX;RLBTX;IBERIOTOXIN;IBERIOTOXIN 98%;Iberiotoxin Standard;IBERIOTOXIN USP/EP/BP;IBERIOTOXIN, RECOMBINANT;IBERIOTOXIN, BUTHUS TAMULUS;129203-60-7/182897-30-9（TFA);IBTX (SCORPION, BUTHUS TAMULUS)
CBNumber
CB8130448
Molecular Formula
C179H274N50O55S7
Formula Weight
4230.84786
MOL File
129203-60-7.mol
More
Less

IBERIOTOXIN Property

storage temp. 
-20°C
solubility 
H2O: 1 mg/mL, clear, colorless
form 
Salt-free lyophilized solid
color 
White to off-white
Water Solubility 
Soluble to 0.70 mg/ml in water
More
Less

Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
28-36/37-45
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
NH6107500
F 
3-10
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
401002
Product name
Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem
Packaging
10μg
Price
$265
Updated
2024/03/01
Sigma-Aldrich
Product number
I5904
Product name
Iberiotoxin, recombinant from Mesobuthus tamulus
Purity
≥98% (HPLC), recombinant, expressed in E. coli
Packaging
5μG
Price
$108
Updated
2023/06/20
Sigma-Aldrich
Product number
I5904
Product name
Iberiotoxin, recombinant from Mesobuthus tamulus
Purity
≥98% (HPLC), recombinant, expressed in E. coli
Packaging
10μG
Price
$184
Updated
2023/06/20
Sigma-Aldrich
Product number
I5904
Product name
Iberiotoxin, recombinant from Mesobuthus tamulus
Purity
≥98% (HPLC), recombinant, expressed in E. coli
Packaging
100μG
Price
$541
Updated
2023/06/20
Tocris
Product number
1086
Product name
Iberiotoxin
Packaging
100U
Price
$333
Updated
2021/12/16
More
Less

IBERIOTOXIN Chemical Properties,Usage,Production

Uses

Iberiotoxin is a selective and reversible inhibitor of high-conductance calcium-activated potassium channel. A toxin purified from the Eastern Indian red scorpion Buthus tamulus.

Uses

Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K+ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca2+- activated K+ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.

Uses

Selective probe for high-conductance calcium-activated potassium channels.

Biological Activity

iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion mesobuthus tamulus and was shown to selectively block large conductance ca2+-activated k+ channels(bkca) in smooth muscle cells.in single channel recordings, iberiotoxin can reversibly block outward currents mediated by bkca in excised membrane patches from bovine aortic smooth muscle with an ic50 value of 250 pm. it is also a noncompetitive, partial inhibitor of charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (ki = 250 pm).[1]. galvez a, gimenez-gallego g, reuben j p, et al. purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion buthus tamulus. the journal of biological chemisty, 1990, 265(19): 11083-11090.

Biochem/physiol Actions

The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.

storage

-20°C (desiccate)

IBERIOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

IBERIOTOXIN Suppliers

China 56 Europe 1 France 1 Germany 3 Japan 1 Switzerland 3 United Kingdom 3 United States 12 Global 80
Hefei KS-V Peptide Biotechnology Co., Ltd.
Tel
0551-65120828 17368858770
Email
sales1@difficultpeptide.com
Country
China
ProdList
118
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@163.com
Country
China
ProdList
283
Advantage
58
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55

129203-60-7, IBERIOTOXINRelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide PHENYLSELENOL METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) COBALT(II) ACETYLACETONATE Cupric acetylacetonate Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate N-BUTYLISOCYANIDE Ethyl isocyanoacetate SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE

  • IBTX
  • IBTX (SCORPION, BUTHUS TAMULUS)
  • IBERIOTOXIN
  • IBERIOTOXIN, BUTHUS TAMULUS
  • IBERIOTOXIN SCORPION BUTHUS TAMULUS
  • PGLU-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN [DISULFIDE BRIDGES: 7-28, 13-3, 17-3]
  • RLBTX
  • PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
  • PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)
  • PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN
  • Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem
  • iberiotoxin from buthus tamulus
  • IBERIOTOXIN FROM BUTHUS TAMULUS, 50 UG*
  • IBERIOTOXIN, RECOMBINANT
  • IBERIOTOXIN 98%
  • PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH
  • PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH (DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)
  • M.W. 4230.91 C179H274N50O55S7
  • pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH
  • Iberiotoxin, recombinant from Mesobuthus tamulus
  • IBERIOTOXIN USP/EP/BP
  • Iberiotoxin Standard
  • 129203-60-7/182897-30-9（TFA)
  • 129203-60-7
  • C179H274N50O55S7
  • C179H273N49O56S7
  • Voltage-gated Ion Channels
  • Potassium Channel Modulators
  • Other
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Monovalent Ion Channels
  • Ion Channels
  • BioChemical
  • Biochemicals and Reagents
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Other
  • Potassium channel
  • Ion Channel Modulating Peptides
  • Potassium Channel ModulatorsPeptides for Cell Biology
  • Monovalent Ion Channels
  • Potassium Channel ModulatorsCell Signaling and Neuroscience
  • Scorpion
  • Toxins and Venoms
  • Voltage-gated Ion Channels