ChemicalBook > CAS DataBase List > 2-Methoxy-4-methylpyridine
2-Methoxy-4-methylpyridine
- Product Name
- 2-Methoxy-4-methylpyridine
- CAS No.
- 100848-70-2
- Chemical Name
- 2-Methoxy-4-methylpyridine
- Synonyms
- CAS:100848-70-2;2-Methoxy-p-picoline;2-METHOXY-4-PICOLINE;2-METHOXY-4-METHYLPYRIDINE;2-METHOXY-4-METHYLPYRIDINEV;Pyridine, 2-methoxy-4-methyl-;2-Methoxy-4-methylpyridine>2-Methoxy-4-methylpyridine 97%;2-Methoxy-4-Methylpyridine,97%;Pyridine, 2-methoxy-4-methyl- (9CI)
- CBNumber
- CB1442933
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 100848-70-2.mol
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2-Methoxy-4-methylpyridine Property
- Melting point:
- 136 °C
- Boiling point:
- 152-153 °C (lit.)
- Density
- 1.001±0.06 g/cm3(Predicted)
- refractive index
- 1.4990-1.5030
- Flash point:
- 53 °C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 4.07±0.10(Predicted)
- form
- clear liquid
- color
- Colorless to Almost colorless
- CAS DataBase Reference
- 100848-70-2(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 29339900
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 578525
- Product name
- 2-Methoxy-4-methylpyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $197
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M2190
- Product name
- 2-Methoxy-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $51
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2190
- Product name
- 2-Methoxy-4-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $158
- Updated
- 2025/07/31
TRC
- Product number
- M332393
- Product name
- 2-Methoxy-4-methylpyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
AK Scientific
- Product number
- J56477
- Product name
- 2-Methoxy-4-methylpyridine
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
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2-Methoxy-4-methylpyridine Chemical Properties,Usage,Production
Description
2-Methoxy-4-methylpyridine is an organic intermediate, which can be prepared by nucleophilic substitution of 2-chloro-4-methylpyridine with sodium methoxide.
Uses
2-Methoxy-4-methylpyridine is a heterocyclic organic compound and can be used as an organic intermediate.
Preparation
The mixture of 2-chloro-4-picoline and NaOCH3 in DMSO was extracted with ethyl acetate and reacted to obtain 2-methoxy-4-picoline.
Synthesis
13466-41-6
74-88-4
100848-70-2
To a stirred solution of 2-hydroxy-4-methylpyridine (10 g, 92 mmol) in chloroform (350 mL) was sequentially added silver carbonate (34.2 g, 124 mmol) and iodomethane (130 g, 920 mmol) at room temperature. The reaction mixture was stirred continuously under light-avoidance conditions for 48 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with ether. The filtrate was concentrated at a temperature below 20 °C and the resulting residue was purified by column chromatography using n-pentane/ether (5:1, v/v) as eluent to afford 2-methoxy-4-methylpyridine (8.0 g, 71% yield) as a colorless oil. The structure of the product was characterized by 1H NMR (CDCl3, δ): 8.02 (d, 1H, J=5.4 Hz), 6.69 (d, 1H, J=5.4 Hz), 6.55 (s, 1H), 3.91 (s, 3H), 2.28 (s, 3H); 13C NMR (CDCl3, δ): 164.40, 149.72, 146.31. 118.21, 110.88, 53.17, 20.81; Mass Spectrometry (MS) m/z (relative abundance): 123 (M+, 76%), 122 (100%) confirmed.
References
[1] Tetrahedron Letters, 1997, vol. 38, # 35, p. 6153 - 6156
[2] Patent: WO2005/806, 2005, A2. Location in patent: Page 72
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 6, p. 921 - 924
2-Methoxy-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methoxy-4-methylpyridine manufacturers
Dideu Industries Group Limited
- Product
- 2-Methoxy-4-methylpyridine 100848-70-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25
100848-70-2, 2-Methoxy-4-methylpyridineRelated Search:
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