Description References
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Pyrazine

Description References
Product Name
Pyrazine
CAS No.
290-37-9
Chemical Name
Pyrazine
Synonyms
Pyrazin;PyBO;Piazine;Paradiazine;PYRAZINE;FEMA 4015;p-Diazine;1,4-DIAZINE;Pyrazine>1,4-Pyrazine
CBNumber
CB1450659
Molecular Formula
C4H4N2
Formula Weight
80.09
MOL File
290-37-9.mol
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Pyrazine Property

Melting point:
50-56 °C (lit.)
Boiling point:
115-116 °C (lit.)
Density 
1.031 g/mL at 25 °C (lit.)
refractive index 
1.5235
FEMA 
4015 | PYRAZINE
Flash point:
132 °F
storage temp. 
Store below +30°C.
solubility 
SOLUBLE
pka
0.65(at 27℃)
form 
Crystals
color 
White
Specific Gravity
1.031
Odor
at 0.10 % in propylene glycol. pungent sweet corn like roasted hazelnut barly
Odor Type
nutty
biological source
synthetic
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,7957
JECFA Number
951
BRN 
103905
Dielectric constant
2.7999999999999998
Stability:
Stable. Highly flammable. Incompatible with acids, oxidizing agents.
LogP
-0.26
CAS DataBase Reference
290-37-9(CAS DataBase Reference)
NIST Chemistry Reference
Pyrazine(290-37-9)
EPA Substance Registry System
Pyrazine (290-37-9)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38-11
Safety Statements 
26-36-16
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
RTECS 
UQ2015000
TSCA 
T
HazardClass 
4.1
PackingGroup 
III
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W401501
Product name
Pyrazine
Purity
≥99%, FG
Packaging
100g
Price
$75.2
Updated
2024/03/01
Sigma-Aldrich
Product number
W401501
Product name
Pyrazine
Purity
≥99%, FG
Packaging
1kg
Price
$374
Updated
2024/03/01
Sigma-Aldrich
Product number
P56003
Product name
Pyrazine
Purity
≥99%
Packaging
5g
Price
$31.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07064
Product name
Pyrazine
Purity
for synthesis
Packaging
10g
Price
$46.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07064
Product name
Pyrazine
Purity
for synthesis
Packaging
100g
Price
$210
Updated
2024/03/01
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Pyrazine Chemical Properties,Usage,Production

Description

Pyrazine is a heterocyclic aromatic organic compound and can be reacted to obtain diverse pyrazine derivatives. Pyrazines are important contributors to the flavor of various roasted, toasted, or similarly heated foods. Pyrazine derivatives exhibit a wide variety of aromas in food, e.g. 2-methoxy-3-isopropylpyrazine produces a green pea odor. Pyrazines and pyrazine derivatives are typically used as flavor agent. Pyrazines and Pyrazine derivatives are also used as fragrances.

References

[1] T.B. Adamsa, J. Doullb, V.J. Feronc, J.I. Goodmand, L.J. Marnette, I.C. Munrof, P.M. Newberneg, P.S. Portogheseh, R.L. Smithi, W.J. Waddellj and B.M. Wagnerk, The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients, Food and Chemical Toxicology, 2002, vol. 40, 429-451

Chemical Properties

white crystals or powder

Chemical Properties

Pyrazine has a strong pyridine-like odor. Some reports compare the taste of pyrazine to cooked spinach or rancid peanuts

Occurrence

Pyrazine has been detected in several food products including papayas, asparagus, peanuts, popcorn, soybeans, corn, French fries, bread, cheese, milk, eggs (boiled), chicken (fried), beef (cooked), shrimp, clams, beer, sherry, malt, coffee and tea (green).

Uses

Pyrazine is used as a flavoring agent. It serves as a component of some herbs in traditional Chinese medicine. It is employed as pharmaceutical intermediates, perfume intermediates and involved in the preparation of other chemicals. In addition to this, it is used in the production of pyrazine 1-oxide.

Definition

ChEBI: A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.

Definition

A heterocyclic aromatic compound with a six-membered ring containing four carbon atoms and two nitrogen atoms.

Definition

pyrazine: An unsaturated heterocycliccompound having two nitrogenatoms in a six-membered ring,C4H4N2; r.d. 1.03; m.p. 52°C; b.p.115°C. Pyrazine is a symmetric diazine.

Preparation

Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen.

Aroma threshold values

300 ppm (odor threshold in water)

General Description

Pyrazine is a 1,4-diazine and an electron-deficient N-heteroarene found in several natural products, APIs, agrochemicals, and functional materials.

Purification Methods

Distil pyrazine in steam and crystallise it from water. Purify also by zone melting. [Beilstein 23 H 91, 23 II 80, 23 III/IV 899, 23/5 V 351.]

Pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

Acetylpyrazine Zopiclone Norfloxacin Cefoperazone Praziquantel
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Pyrazine Suppliers

Americas 1 Belgium 3 Canada 1 China 297 Europe 1 France 2 Germany 5 India 12 Japan 6 Spain 1 Switzerland 2 United Kingdom 14 United States 48 Global 393
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View Lastest Price from Pyrazine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Pyrazine 290-37-9
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-06
JINING XINHE CHEMICAL CO., LTD
Product
Pyrazine 290-37-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10ton
Release date
2024-07-22
Henan Fengda Chemical Co., Ltd
Product
Pyrazine 290-37-9
Price
US $32.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-22

290-37-9, PyrazineRelated Search:

DBU Sulfanilic acid Methylparaben p-Toluic acid p-Phenylenediamine Glipizide 4-Aminobenzoic acid 4-Nitrobenzoic acid 4-Hydroxybenzoic acid 4-Hydroxybenzaldehyde 2-cyclohexyl-carbonyl-1,3,4,6,7,11b-hexahydro-2h-pyrazine(2,1-a)isoquinoline-4-one Pyrazole Phenazine 2,3-Pyrazinedicarboxylic acid 2-Pyrazinecarboxylic acid ALLOXAZINE 2-Chloropyrazine LUMICHROME

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  • Flavors and Fragrances
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