4-CHLORO-6-NITROQUINAZOLINE
- Product Name
- 4-CHLORO-6-NITROQUINAZOLINE
- CAS No.
- 19815-16-8
- Chemical Name
- 4-CHLORO-6-NITROQUINAZOLINE
- Synonyms
- 4-Chloro-6-nitro-quizoline;4-choro-6-nitroquinazoline;4-CHLORO-6-NITROQUINAZOLINE;Quinazoline,4-chloro-6-nitro-
- CBNumber
- CB1450967
- Molecular Formula
- C8H4ClN3O2
- Formula Weight
- 209.59
- MOL File
- 19815-16-8.mol
4-CHLORO-6-NITROQUINAZOLINE Property
- Melting point:
- 128 °C
- Boiling point:
- 380.0±22.0 °C(Predicted)
- Density
- 1.566±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Dichloromethane
- form
- Solid
- pka
- 0.14±0.50(Predicted)
- color
- Brown
- CAS DataBase Reference
- 19815-16-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374785
- Product name
- 4-Chloro-6-nitroquinazoline
- Packaging
- 250mg
- Price
- $1095
- Updated
- 2021/12/16
- Product number
- 4H54-5-07
- Product name
- 4-Chloro-6-nitroquinazoline
- Purity
- 98%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-D0329
- Product name
- 4-CHLORO-6-NITROQUINAZOLINE
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FC20158
- Product name
- 4-Chloro-6-nitroquinazoline
- Packaging
- 10mg
- Price
- $139.8
- Updated
- 2021/12/16
- Product number
- 4H54-5-07
- Product name
- 4-Chloro-6-nitroquinazoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $202
- Updated
- 2021/12/16
4-CHLORO-6-NITROQUINAZOLINE Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of anticancer agents and enzyme inhibitors.
Synthesis
6943-17-5
19815-16-8
Step 1: Synthesis of 4-chloro-6-nitroquinazoline To a solution of toluene (200 mL) containing 6-nitroquinazolin-4-ol (9.00 g, 47.1 mmol) and triethylamine (TEA, 9.53 g, 94.2 mmol) was slowly added phosphorus oxychloride (POCl3, 5.2 mL, 56.8 mmol) at 25 °C. Subsequently, the reaction mixture was heated to 80 °C and stirred at this temperature for 3.0 hours. Upon completion of the reaction, the mixture was cooled to 25 °C and diluted with the addition of toluene (100 mL). The organic phase was separated, washed with ice water (50 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated by decompression to afford the title compound 4-chloro-6-nitroquinazoline as a yellow solid (7.00 g, 64.2% yield). The structure of the compound was confirmed by the following spectral data: 1H NMR (400 MHz, DMSO-d6) δ: 8.78 (s, 1H), 8.54 (d, J = 6.8 Hz, 1H), 8.39 (s, 1H), 7.87 (d, J = 12.4 Hz, 1H).
References
[1] Patent: CN108373452, 2018, A. Location in patent: Paragraph 0010; 0024; 0036-0041; 0050-0053
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 12, p. 3974 - 3980
[3] Chinese Journal of Chemistry, 2014, vol. 32, # 6, p. 538 - 544
[4] Patent: WO2014/177038, 2014, A1. Location in patent: Paragraph 00255-00256
[5] Tetrahedron Letters, 2012, vol. 53, # 6, p. 674 - 677
4-CHLORO-6-NITROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-6-NITROQUINAZOLINE Suppliers
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- Country
- Canada
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View Lastest Price from 4-CHLORO-6-NITROQUINAZOLINE manufacturers
- Product
- 4-CHLORO-6-NITROQUINAZOLINE 19815-16-8
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25