ChemicalBook > CAS DataBase List > 4-CHLORO-6-NITROQUINAZOLINE

4-CHLORO-6-NITROQUINAZOLINE

Product Name
4-CHLORO-6-NITROQUINAZOLINE
CAS No.
19815-16-8
Chemical Name
4-CHLORO-6-NITROQUINAZOLINE
Synonyms
4-Chloro-6-nitro-quizoline;4-choro-6-nitroquinazoline;4-CHLORO-6-NITROQUINAZOLINE;Quinazoline,4-chloro-6-nitro-
CBNumber
CB1450967
Molecular Formula
C8H4ClN3O2
Formula Weight
209.59
MOL File
19815-16-8.mol
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4-CHLORO-6-NITROQUINAZOLINE Property

Melting point:
128 °C
Boiling point:
380.0±22.0 °C(Predicted)
Density 
1.566±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Dichloromethane
form 
Solid
pka
0.14±0.50(Predicted)
color 
Brown
CAS DataBase Reference
19815-16-8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C374785
Product name
4-Chloro-6-nitroquinazoline
Packaging
250mg
Price
$1095
Updated
2021/12/16
SynQuest Laboratories
Product number
4H54-5-07
Product name
4-Chloro-6-nitroquinazoline
Purity
98%
Packaging
250mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-D0329
Product name
4-CHLORO-6-NITROQUINAZOLINE
Packaging
1g
Price
$98
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20158
Product name
4-Chloro-6-nitroquinazoline
Packaging
10mg
Price
$139.8
Updated
2021/12/16
SynQuest Laboratories
Product number
4H54-5-07
Product name
4-Chloro-6-nitroquinazoline
Purity
98%
Packaging
1g
Price
$202
Updated
2021/12/16
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4-CHLORO-6-NITROQUINAZOLINE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Intermediate in the preparation of anticancer agents and enzyme inhibitors.

Synthesis

6943-17-5

19815-16-8

Step 1: Synthesis of 4-chloro-6-nitroquinazoline To a solution of toluene (200 mL) containing 6-nitroquinazolin-4-ol (9.00 g, 47.1 mmol) and triethylamine (TEA, 9.53 g, 94.2 mmol) was slowly added phosphorus oxychloride (POCl3, 5.2 mL, 56.8 mmol) at 25 °C. Subsequently, the reaction mixture was heated to 80 °C and stirred at this temperature for 3.0 hours. Upon completion of the reaction, the mixture was cooled to 25 °C and diluted with the addition of toluene (100 mL). The organic phase was separated, washed with ice water (50 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated by decompression to afford the title compound 4-chloro-6-nitroquinazoline as a yellow solid (7.00 g, 64.2% yield). The structure of the compound was confirmed by the following spectral data: 1H NMR (400 MHz, DMSO-d6) δ: 8.78 (s, 1H), 8.54 (d, J = 6.8 Hz, 1H), 8.39 (s, 1H), 7.87 (d, J = 12.4 Hz, 1H).

References

[1] Patent: CN108373452, 2018, A. Location in patent: Paragraph 0010; 0024; 0036-0041; 0050-0053
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 12, p. 3974 - 3980
[3] Chinese Journal of Chemistry, 2014, vol. 32, # 6, p. 538 - 544
[4] Patent: WO2014/177038, 2014, A1. Location in patent: Paragraph 00255-00256
[5] Tetrahedron Letters, 2012, vol. 53, # 6, p. 674 - 677

4-CHLORO-6-NITROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6-NITROQUINAZOLINE Suppliers

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View Lastest Price from 4-CHLORO-6-NITROQUINAZOLINE manufacturers

Career Henan Chemical Co
Product
4-CHLORO-6-NITROQUINAZOLINE 19815-16-8
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2019-12-25

19815-16-8, 4-CHLORO-6-NITROQUINAZOLINERelated Search:

(6-Chloro-pyrimidin-4-yl)-dimethyl-amine ETHYL 4-CHLORO-6-FLUORO-3-QUINOLINECARBOXYLATE 4-CHLORO-6-FLUOROQUINAZOLINE 4-CHLORO-6-(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 2,6-Dichloro-5-nitroquinoline 8-chloro-5-nitro-quinoline 4-CHLORO-6-NITROQUINAZOLINE 6-CHLORO-5-NITROQUINOLINE 4-Chloro-3-nitroquinoline 2-CHLORO-6-NITROQUINOLINE 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE QUINAZOLINE, 2,4-DICHLORO-6-NITRO 4-CHLORO-7-NITROQUINAZOLINE 4-CHLORO-8-NITROQUINAZOLINE 2-[4-Methyl-1-piperazinyl]-4-chloro-7-nitroquinazoline 2-[4-Methyl-1-piperazinyl]-4-chloro-6-nitroquinazoline 4-CHLORO-6-NITRO-N-(PHENYLMETHYL)-2-QUINAZOLINECARBOXAMIDE 4-chloro-2-methyl-6-nitroquinazoline

  • 4-CHLORO-6-NITROQUINAZOLINE
  • Quinazoline,4-chloro-6-nitro-
  • 4-choro-6-nitroquinazoline
  • 4-Chloro-6-nitro-quizoline
  • 19815-16-8
  • 10.9815-16-8
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