2-CHLOROQUINOLINE-3-CARBALDEHYDE
- Product Name
- 2-CHLOROQUINOLINE-3-CARBALDEHYDE
- CAS No.
- 73568-25-9
- Chemical Name
- 2-CHLOROQUINOLINE-3-CARBALDEHYDE
- Synonyms
- SBB000302;ZINC00061503;AKOS AU36-M569;390119_ALDRICH;ASISCHEM C51996;AKOS BBS-00001118;RARECHEM AK ML 0551;TIMTEC-BB SBB000302;IFLAB-BB F0010-0600;2-Chloro-3-formylquinoline
- CBNumber
- CB1451393
- Molecular Formula
- C10H6ClNO
- Formula Weight
- 191.61
- MOL File
- 73568-25-9.mol
2-CHLOROQUINOLINE-3-CARBALDEHYDE Property
- Melting point:
- 148-150 °C (lit.)
- Boiling point:
- 335.8±22.0 °C(Predicted)
- Density
- 1.364
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- -1.31±0.50(Predicted)
- form
- Liquid
- color
- Clear colorless to yellow
- Sensitive
- Air Sensitive
- InChIKey
- SDKQWXCBSNMYBN-UHFFFAOYSA-N
- CAS DataBase Reference
- 73568-25-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 390119
- Product name
- 2-Chloro-3-quinolinecarboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $33
- Updated
- 2023/01/07
- Product number
- 390119
- Product name
- 2-Chloro-3-quinolinecarboxaldehyde
- Purity
- 98%
- Packaging
- 10g
- Price
- $165
- Updated
- 2023/01/07
- Product number
- C2289
- Product name
- 2-Chloro-3-quinolinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- C2289
- Product name
- 2-Chloro-3-quinolinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- C381378
- Product name
- 2-Chloroquinoline-3-carbaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
2-CHLOROQUINOLINE-3-CARBALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Yellow to yellow-brown crystalline powder
Synthesis
612-62-4
73568-25-9
Example 7 Synthesis of 2-chloro-3-quinolinecarboxaldehyde: 1.53 mL (3.30 mmol) of n-butyllithium (n-BuLi) was added slowly and dropwise to an 8 mL THF solution containing 0.46 mL (3.30 mmol) of diisopropylamine at 0 °C. After 20 minutes of reaction, the solution was cooled to -78 °C and 2-chloroquinoline (491 mg, 3.0 mmol) was added at this temperature. The mixture was stirred at -78 °C for 30 min, followed by dropwise addition of dimethylformamide (0.39 mL, 5.04 mmol) and continued stirring at the same temperature for 30 min. Upon completion of the reaction, the reaction was quenched with glacial acetic acid (1 mL) at -78 °C, then the mixture was slowly warmed to room temperature and diluted with ether (30 mL). The organic phase was washed sequentially with saturated NaHCO3 solution (10 mL) and brine (10 mL) and dried over anhydrous MgSO4. Concentration gave 2-chloro-3-quinolinecarboxaldehyde (530 mg, 92% yield) as a light yellow solid with melting point 145-149 °C, which could be used in the next reaction without further purification. By recrystallization from ethyl acetate, a pure product was obtained as pale yellow acicular crystals with a melting point of 149-150 °C (literature values 148-149 °C, see Meth-Cohn, O.; Narhe, B.; Tarnowski, B. J. Chem. Soc. Perkin Trans. I 1981, 1520).1H NMR (300 MHz, CDCl3) δ 10.57 (s, 1H), 8.77 (s, 1H), 8.08 (d, 1H, J = 9 Hz), 8.0 (d, 1H, J = 9 Hz), 7.90 (t, 1H, J = 9 Hz), 7.67 (t, 1H, J = 9 Hz); IR (nujol) 1685, 1575, 1045, 760, 745 cm-1. 745 cm-1.
References
[1] Patent: US5212317, 1993, A
[2] Patent: US5162532, 1992, A
2-CHLOROQUINOLINE-3-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLOROQUINOLINE-3-CARBALDEHYDE manufacturers
- Product
- 2-CHLOROQUINOLINE-3-CARBALDEHYDE 73568-25-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
- Product
- 2-CHLOROQUINOLINE-3-CARBALDEHYDE 73568-25-9
- Price
- US $30.00-10.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 100000kg
- Release date
- 2024-08-23
- Product
- 2-CHLOROQUINOLINE-3-CARBALDEHYDE 73568-25-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13